New Perspectives in Transporter Biology (FASEB Conference)

转运蛋白生物学的新视角（FASEB 会议）

• 批准号: 7000973
• 负责人: Michael Byrne Robinson
• 金额: $ 4.04万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-15 至 2006-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7000973
• 关键词: meeting /conference /symposium; membrane transport proteins; protein structure function; travel

DESCRIPTION (provided by applicant): This application represents a request for support of a conference that will be held under the auspices of the Federation of American Societies of Experimental Biology (FASEB), entitled "New Perspectives in Transporter Biology". The fifth bi-annual FASEB conference on this topic is scheduled to occur at Vermont Academy in Saxtons River, Vermont starting on July 23rd and ending on July 28th of 2005. This conference focuses on transporters, a large class of membrane proteins that are essential for diverse phenomena, including absorption and distribution of nutrients, selective renal excretion of metabolites, movement of molecules across the blood brain barrier, packaging of neurotransmitters into vesicles, and clearance/termination of synaptically released neurotransmitter. Over the last 15 years, the sophistication of studies of transporter processes has dramatically improved because of the cloning and subsequent development of tools (antibodies, expression systems, etc) that can be used for their study. The past year and half have been a watershed in transporter biology. There is now structural information on a few members of the family, this is increasing sophistication in our understanding of the genomics of drug metabolism/action brought about by studies of human polymorphisms, and new techniques/model systems have been developed to study transporter biology. Altered function and/or mutations in these transporters have been implicated in diverse diseases, including epilepsy, head trauma, amyotrophic lateral sclerosis (ALS), depression, attention deficit hyperactivity disorder (ADHD), diabetes, orthostatic hypotension, cystinuria, cystic fibrosis, HHH syndrome, etc; there is a growing list of 'transporteropathies'. Although some drugs target these transporters (anti-depressants, antiseizure, drugs to treat ADHD), this is still a surprisingly small number of drugs considering the number of membrane targets represented by this class of functionally related proteins. This meeting brings together individuals who use structural, biophysical, molecular, pharmacogenomic, biochemical, cell biological, and physiological techniques to study these proteins. Furthermore, it brings together individuals who have interests in diverse organ systems and disease processes. An over-riding goal of this meeting is to facilitate cross-fertilization and collaboration between the various disciplines that study transporters. The long-term goal of this meeting is to cultivate consortiums of individuals who will work together programmatically to study this important class of membrane proteins.

描述（由申请人提供）：本申请代表对将在美国实验生物学会联合会 (FASEB) 主办的题为“转运蛋白生物学的新观点”的会议的支持请求。 关于这一主题的第五次半年度 FASEB 会议计划于 2005 年 7 月 23 日开始至 2005 年 7 月 28 日在佛蒙特州萨克斯顿河的佛蒙特学院举行。 本次会议重点讨论转运蛋白，这是一大类膜蛋白，对多种现象至关重要，包括营养物质的吸收和分配、代谢物的选择性肾脏排泄、分子穿过血脑屏障的运动、将神经递质包装到囊泡中以及清除/突触释放的神经递质的终止。 在过去的 15 年里，由于可用于转运蛋白研究的工具（抗体、表达系统等）的克隆和后续开发，转运蛋白过程研究的复杂性得到了显着提高。 过去的一年半是转运蛋白生物学的分水岭。 现在有了该家族一些成员的结构信息，这使我们对人类多态性研究带来的药物代谢/作用基因组学的理解日益复杂，并且已经开发了新技术/模型系统来研究转运蛋白生物学。 这些转运蛋白的功能改变和/或突变与多种疾病有关，包括癫痫、头部外伤、肌萎缩侧索硬化症 (ALS)、抑郁症、注意力缺陷多动障碍 (ADHD)、糖尿病、直立性低血压、胱氨酸尿症、囊性纤维化、HHH综合症等； “转运病”的名单越来越多。 尽管一些药物针对这些转运蛋白（抗抑郁药、抗癫痫药、治疗多动症的药物），但考虑到此类功能相关蛋白所代表的膜靶标的数量，这仍然是少数药物。 这次会议汇集了使用结构、生物物理、分子、药物基因组学、生物化学、细胞生物学和生理学技术来研究这些蛋白质的个人。 此外，它汇集了对不同器官系统和疾病过程感兴趣的个人。 这次会议的首要目标是促进研究转运蛋白的各个学科之间的交叉融合和合作。 这次会议的长期目标是培养个人联盟，他们将有计划地共同研究这一类重要的膜蛋白。