Columbia-South Africa Training Program for Research on HIV-associated Malignanci

哥伦比亚-南非艾滋病毒相关恶性肿瘤研究培训计划

• 批准号: 8009645
• 负责人: ALFRED I. NEUGUT
• 金额: $ 53.12万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-27 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8009645
• 关键词: AIDS/HIV problem; Achievement; Acquired Immunodeficiency Syndrome; Acute; Africa South of the Sahara; Anti-Retroviral Agents; Biometry; Child; Clinical Research; Collaborations; Commit; Data; Development; Disease; Educational workshop; Environmental Health; Epidemic; Epidemiologist; Epidemiology; Faculty; Funding; Generations; Grant; HIV; HIV Infections; Herbert Irving Comprehensive Cancer Center; Incidence; Infection; Institution; International AIDS; Journals; Kaposi Sarcoma; Laboratories; Laboratory Scientists; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Mentors; Nature; Non-Hodgkin' s Lymphoma; Oncologist; Paper; Participant; Pathogenesis; Patients; Play; Positioning Attribute; Prevention; Public Health; Public Health Schools; Publishing; Research; Research Infrastructure; Research Personnel; Research Training; Resources; Role; Science; Scientist; South Africa; Southern Africa; Specimen; Techniques; Technology; Testing; Training; Training Programs; Tuberculosis; Universities; Woman; Work; base; bench to bedside; clinical care; clinical epidemiology; cost; global health; improved; meetings; men; mortality; multidisciplinary; neoplasm registry; novel strategies; pandemic disease; patient oriented; population based; programs

DESCRIPTION (provided by applicant): In sub-Saharan Africa, Kaposi sarcoma (KS) and non-Hodgkin lymphoma (NHL) incidence and mortality rates have risen dramatically as the HIV/AIDS epidemic has evolved. In the developed world, cervical cancer is also HIV-related, but sub-Saharan Africa had among the world's highest cervical cancer rates even before the HIV/AIDS epidemic. Access to anti-retroviral therapy and survival with AIDS are improving, but HIV- related malignancies are an increasingly urgent public health problem for men, women, and children in South Africa. We propose to strengthen research capacity in KS, NHL, and cervical cancer through a training collaboration with institutions in South Africa, building on the achievements of the Mailman School of Public Health of Columbia University (CU). Since 1994, our Southern Africa Fogarty AIDS International Training and Research Program (CU-SA AITRP) based at the University of KwaZulu-Natal (KZN) has played a vital role in creating science infrastructure to meet the challenges of HIV in South Africa, the epicenter of the global HIV pandemic. The CU-SA AITRP's >300 trainees have published >900 papers, in such journals as Science, Nature and the Lancet. Ex-trainees are now global leaders in research on HIV pathogenesis in acute HIV infection, new prevention technologies, and new approaches to treating HIV-TB co-infection. Similarly, for nearly 25 years, we have had an NCI-funded T32 training grant, and for 7 years an R25 training grant; both are collaborations of faculty in Epidemiology, Biostatistics, and Environmental Health Sciences and CU's NCI- funded Herbert Irving Comprehensive Cancer Center. Providing a multidisciplinary perspective, the two programs have trained more than 100 cancer researchers who have gone on to prestigious academic and research positions. Our prior D43 grant generated data confirming the high rates of KS and the problem of managing it in KZN given the heavy burden of co-morbid tuberculosis (TB). Each year, our collaborators at the University of KZN see >150 new patients with KS, those at Stellenbosch University >100 new cases of NHL, and those at the University of Witwatersrand >200 new cases of cervical cancer. In the proposed 3- year grant, our team of leading cancer epidemiologists, oncologists, and laboratory scientists will focus on those 3 cancers, working with 18 pre- and postdoctoral trainees and with colleagues in South Africa who are providing clinical care, conducting trials, and collecting specimens for study. Trainees will take courses at CU and the collaborating universities in South Africa. Some will acquire specific expertise in needed laboratory techniques; others will be trained in patient-oriented clinical research or public-health oriented epidemiology (potentially applicable to building a much-needed population-based cancer registry). We will conduct two workshops in cancer and clinical epidemiology in South Africa. All trainees will receive mentoring, and all participants will be committed to building long-term collaborations and research capacity on HIV-related malignancies in resource-limited settings (e.g., development of a quick, low-cost KS test). RELEVANCE: This program is a critical training resource to strengthen the institutional base for pivotal bench-to-bedside research on the three major HIV-related malignancies at institutions dealing with the burden of those diseases in the epicenter of the-HIV pandemic and to give the rising generation of scientists a global health perspective.

描述（由申请人提供）：在撒哈拉以南非洲，Kaposi肉瘤（KS）和非霍奇金淋巴瘤（NHL）发病率和死亡率率显着上升，因为HIV/AIDS流行的流行已经发展。在发达国家中，宫颈癌也与HIV有关，但撒哈拉以南非洲甚至在艾滋病毒/艾滋病流行之前就处于世界上最高的宫颈癌率。获得抗逆转录病毒疗法和艾滋病生存的机会正在改善，但与南非男性，女性和儿童有关HIV相关的恶性肿瘤是日益紧迫的公共卫生问题。我们建议通过与南非机构的培训合作来增强KS，NHL和宫颈癌的研究能力，这是建立哥伦比亚大学公共卫生学院（CU）的成就的基础。自1994年以来，我们的南部非洲Fogarty AIDS国际培训和研究计划（CU-SA AITRP）总部位于夸祖鲁 - 纳塔尔大学（KZN）（KZN）在建立科学基础设施方面发挥了至关重要的作用，以应对南非的艾滋病毒挑战，这是全球HIV Pandmemic的Epcenter。 Cu-Sa AITRP> 300名学员在科学，自然和柳叶刀等期刊上发表了> 900篇论文。前训练者现在是急性HIV感染，新的预防技术和治疗HIV-TB共同感染的新方法研究HIV发病机理研究的全球领导者。同样，在将近25年的时间里，我们获得了NCI资助的T32培训补助金，并获得了7年的R25培训补助金；两者都是流行病学，生物统计学和环境健康科学领域的教师以及CU资助的Herbert Irving综合癌症中心的合作。这两个计划提供了多学科的观点，已经培训了100多名癌症研究人员，他们继续担任著名的学术和研究职位。我们以前的D43赠款生成的数据证实了KS的高率以及在KZN中进行管理的问题，鉴于联合性结核病（TB）的沉重负担。每年，我们在KZN大学的合作者会看到150名KS的新患者，Stellenbosch大学的患者> 100例NHL病例，以及Witwatersrand University的患者> 200例宫颈癌病例。在拟议的三年赠款中，我们领先的癌症流行病学家，肿瘤学家和实验室科学家团队将专注于这三种癌症，与18名前和博士后学员一起工作，以及正在提供临床护理，进行临床护理，进行试验和收集研究标本的南非同事。学员将在CU和南非的合作大学上学课程。有些人将获得所需的实验室技术的特定专业知识；其他人将接受针对患者的临床研究或面向公共卫生的流行病学培训（可能适用于建立急需的基于人群的癌症注册表）。我们将在南非举办两次有关癌症和临床流行病学的研讨会。所有学员都将获得指导，所有参与者将致力于在资源有限的环境中建立与HIV相关的恶性肿瘤的长期合作和研究能力（例如，开发快速，低成本的KS测试）。相关性：该计划是一项关键的培训资源，旨在加强对与HIV大流行病中这些疾病负担的机构的三种主要艾滋病毒相关的恶性肿瘤的关键基础研究的机构基础，并使科学家崛起的一代人的全球健康观点具有全球健康的观点。