Social Isolation, Behavior, and Autonomic Function

社会孤立、行为和自主功能

• 批准号: 6965510
• 负责人: ANGELA J GRIPPO
• 金额: $ 4.83万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2007-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6965510
• 关键词: anxiety; brain metabolism; cardiovascular disorder; cardiovascular function; corticosterone; depression; exploratory behavior; heart rate; hormone metabolism; hormone regulation /control mechanism; immunocytochemistry; isolation /deprivation; mood disorders; neurohormones; neuropsychology; oxytocin; paraventricular nucleus; postdoctoral investigator; psychological reinforcement; psychological stressor; psychomotor function; radioimmunoassay; suprachiasmatic nucleus; telemetry; vole

DESCRIPTION (provided by applicant): This proposal addresses central oxytocinergic mechanisms underlying the interactions of affective behaviors, neuroendocrine function, and autonomic activity by investigating the effects of social isolation in female prairie voles. This research is directly relevant to health issues such as social behavior, depression, anxiety, and heart disease. Study 1 employs radioimmunoassay, enzyme immunoassay, and immunocytochemistry to investigate the time course of hormone changes in plasma and hypothalamic brain tissue following social isolation in voles (Aim 1). Study 2 examines depression- and anxiety-like behaviors and endocrine function, and uses radiotelemetry to measure autonomic parameters, in response to social isolation (Aim 2). Study 3 investigates specific oxytocinergic mechanisms that might underlie stressor-induced changes by examining central (intracerebroventricular) administration of oxytocin and/or an oxytocin antagonist to alter the behavioral, neuroendocrine, and autonomic responses to social isolation (Aim 3). The present research will enhance our understanding of how the social environment impacts behavior, physiology, and brain function, and can aid in developing new treatments for patients with affective disorders and cardiovascular disease.

描述（由申请人提供）：该提案通过研究社会隔离在女性草原田鼠中的影响，解决了情感行为，神经内分泌功能和自主活动的相互作用的基础的中央催产机制。这项研究与社会行为，抑郁，焦虑和心脏病等健康问题直接相关。研究1利用放射免疫测定，酶免疫测定和免疫细胞化学来研究田鼠社会隔离后血浆和下丘脑脑组织激素变化的时间过程（AIM 1）。研究2研究了抑郁症和焦虑症的行为和内分泌功能，并使用radiotelemetry来响应社会隔离来衡量自主参数（AIM 2）。研究3研究了特定的催产机制，这些机制可能通过检查催产素和/或催产素拮抗剂的中心（脑室内）给药来改变应激源引起的变化，以改变行为，神经内分泌和对社会隔离的行为反应（AIM 3）。本研究将增强我们对社会环境如何影响行为，生理和大脑功能的理解，并可以帮助为情感障碍和心血管疾病的患者开发新的治疗方法。