Mechanisms of Depression and Cardiovascular Pathology

抑郁症和心血管病理学机制

• 批准号: 6486328
• 负责人: ANGELA J GRIPPO
• 金额: $ 2.44万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6486328
• 关键词: atropine; autonomic disorder; baroreflex; beta antiadrenergic agent; cardiovascular pharmacology; depression; fluoxetine; laboratory rat; mood disorders; pleasure; psychopharmacology; psychophysiology; serotonin; stress; tachycardia

DESCRIPTION: (provided by applicant): This research proposal addresses physiological mechanisms and processes underlying the association between depression and cardiovascular disease. Human studies demonstrate a strong link between depression and coronary artery disease but have not progressed beyond correlational methods. The current proposal will examine the underlying mechanisms in depression and cardiovascular pathology by using a rodent model of depression (chronic mild stress) and a combination of behavioral, physiological, and pharmacological techniques. Rats will be exposed to chronic mild stress to induce the depression-associated sign of anhedonia (a reduced capacity to experience pleasure), and tested for cardiovascular impairments (Aim 1). Autonomic nervous system imbalance will be examined as a mechanism for the cardiovascular dysfunction (e.g., elevated heart rate and reduced heart rate variability) associated with the chronic mild stress model (Aim 2). In addition, central serotonin activity will be examined as a common pathophysiological factor underlying both depression and cardiovascular/autonomic dysfunction (Aim 3). This research will extend our knowledge of the interactions between psychological and physiological conditions, and possibly prompt the development of new treatments for patients with depression and/or cardiovascular disease.

描述：（由申请人提供）：本研究提案解决 生理机制和过程 抑郁和心血管疾病。人类研究表明了牢固的联系 在抑郁症和冠状动脉疾病之间，但没有进展 相关方法。当前的建议将检查基础 使用啮齿动物模型，抑郁和心血管病理的机制 抑郁症（慢性轻度压力​​）和行为的结合， 生理和药理技术。大鼠将暴露于慢性 轻度压力诱导与抑郁症相关的Anhedonia症状（减少 体验愉悦的能力），并经过心血管障碍的测试 （目标1）。自主神经系统失衡将被检查为一种机制 心血管功能障碍（例如，心率升高和心脏降低 速率变异性）与慢性轻度应力模型相关（AIM 2）。在 此外，中央5-羟色胺活性将被视为常见 抑郁症和抑郁症的病理生理因素 心血管/自主功能障碍（AIM 3）。这项研究将扩大我们的 了解心理与生理之间的相互作用 条件，并可能促使患者开发新治疗 患有抑郁和/或心血管疾病。