Mechanisms of Social Isolation and Environmental Enrichment in an Animal Model

动物模型中的社会孤立和环境丰富机制

基本信息

批准号：
8365308
负责人：
ANGELA J GRIPPO
金额：
$ 35.44万
依托单位：
NORTHERN ILLINOIS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-08-05 至 2016-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8365308
关键词：
Abbreviations Academic Research Enhancement Awards Affective Symptoms Aging American Analysis of Variance Anhedonia Animal Model Animals Anxiety Applications Grants Autonomic Dysfunction Behavior Behavioral Biological Assay Biological Models Blood Pressure Brain Brain Stem Brain region CRH gene Cardiovascular Diseases Cardiovascular Physiology Cardiovascular system Caring Cognition Communication Corticotropin-Releasing Hormone Data Development Emotional Emotions Ensure Environment Equilibrium Exhibits Exposure to Extended Family Family Female Functional disorder Future Genes Grant Heart Heart Diseases Heart Rate Housing Human Individual International Investigation Laboratories Lead Learned Helplessness Life Link Manuscripts Measures Mediating Mental Depression Methodology Modeling Molecular Mood Disorders Moods Nervous System Physiology Neural Pathways Neuraxis Neurobiology Patients Peripheral Physical activity Physiological Physiology Play Population Process Publishing Regulation Reliance Research Research Project Grants Research Proposals Risk Rodent Rodent Model Role Science Social Behavior Social Environment Social isolation Stress Stress and Coping Swimming Tail Suspension Testing United States behavior test biological adaptation to stress depressive symptoms design effective therapy environmental enrichment for laboratory animals experience graduate student heart rate variability immunoreactivity improved innovation neurobiological mechanism novel outreach paraventricular nucleus prairie vole prevent protective effect psychologic relating to nervous system research study response social social attachment stressor success undergraduate student

项目摘要

DESCRIPTION (provided by applicant): This research will investigate the effects of an environmental treatment (environmental enrichment), for preventing the negative emotional and cardiovascular consequences of social isolation in the context of depression and heart disease. There is a bidirectional association between depression and heart disease, and this relationship is especially important for people with specific vulnerabilities such as aging populations or individuals who lack beneficial social experiences. Psychological and physiological responses to social stressors and isolation play an important role in the development of affective symptoms and cardiovascular dysfunction. However, current treatments for individuals with depression and heart disease are significantly limited. The present project will use a rodent model, the socially monogamous prairie vole, to study behavioral, autonomic responses to a social stressor (social isolation), and potential molecular mechanisms that underlie environmental enrichment as a treatment for these negative consequences. Preliminary findings, from our laboratory and others, indicate that environmental enrichment - involving increased stimulation from the environment in the form of inanimate objects and physical activity - has beneficial effects on several central nervous system functions, and can improve emotional reactivity and behaviors associated with depression. The prairie vole is a valuable model system for studying responsiveness to social experiences and neurobiological mechanisms related to mood and cardiovascular function. This species displays several unique social behaviors that mimic those of humans, including living in extended families and forming enduring social bonds; and also exhibits autonomic regulation of the heart similar to humans. Using the prairie vole model, Specific Aim 1 will employ behavioral tests of depression and continuous recording of cardiovascular variables including blood pressure, heart rate, heart rate variability, and autonomic balance, to test the hypothesis that environmental enrichment is an effective treatment for behavioral and cardiovascular consequences of social isolation. Specific Aim 2 will employ measures of central nervous system genes including delta-FosB immunoreactivity, to investigate the hypothesis that long-term alterations in cortical, limbic, and autonomic brain regions underlie the positive effects of environmental enrichment in animals that are socially isolated. This research proposes a novel mechanism by which the social environment impacts behavior, physiology, and brain function, and will promote the development of more comprehensive treatments for patients with depression and cardiovascular disease. PUBLIC HEALTH RELEVANCE: The association between depression and heart disease is bidirectional, and is significantly influenced by the social environment. The current research project will investigate, in an animal model, the ability of an environmental treatment to protect against negative behavioral, cardiovascular, and brain processes associated with mood and cardiovascular dysfunction. This research will lead to the development of more effective treatments for patients with depression and heart disease.

描述（由申请人提供）：本研究将调查环境治疗（环境丰富）的效果，以预防抑郁症和心脏病背景下社会孤立造成的负面情绪和心血管后果。抑郁症和心脏病之间存在双向关联，这种关系对于具有特定脆弱性的人（例如人口老龄化或缺乏有益的社会经历的个人）尤其重要。对社会压力和孤立的心理和生理反应在情感症状和心血管功能障碍的发展中起着重要作用。然而，目前对抑郁症和心脏病患者的治疗方法非常有限。本项目将使用啮齿动物模型，即社会一夫一妻制的草原田鼠，来研究对社会压力源（社会隔离）的行为和自主反应，以及作为治疗这些负面后果的环境富集基础的潜在分子机制。我们实验室和其他实验室的初步研究结果表明，环境丰富——包括以无生命物体和体力活动的形式增加来自环境的刺激——对多种中枢神经系统功能具有有益影响，并且可以改善与抑郁相关的情绪反应和行为。草原田鼠是研究对社会经历的反应以及与情绪和心血管功能相关的神经生物学机制的有价值的模型系统。该物种表现出几种模仿人类的独特社会行为，包括生活在大家庭中并形成持久的社会纽带；并且还表现出与人类相似的心脏自主调节功能。具体目标 1 将使用草原田鼠模型，采用抑郁行为测试和连续记录心血管变量（包括血压、心率、心率变异性和自主平衡），以检验环境丰富是行为和抑郁症有效治疗的假设。社会孤立的心血管后果。具体目标 2 将采用包括 delta-FosB 免疫反应性在内的中枢神经系统基因测量方法，来研究这样的假设：皮层、边缘系统和自主脑区域的长期变化是环境富集对社会孤立动物的积极影响的基础。这项研究提出了一种社会环境影响行为、生理和大脑功能的新机制，并将促进抑郁症和心血管疾病患者更全面的治疗方法的发展。公共卫生相关性：抑郁症与心脏病之间的关联是双向的，并且受到社会环境的显着影响。目前的研究项目将在动物模型中研究环境治疗预防与情绪和心血管功能障碍相关的负面行为、心血管和大脑过程的能力。这项研究将为抑郁症和心脏病患者开发更有效的治疗方法。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Protective neuroendocrine effects of environmental enrichment and voluntary exercise against social isolation: evidence for mediation by limbic structures.

环境丰富和自愿锻炼对社会孤立的保护性神经内分泌作用：边缘结构调节的证据。

DOI：
10.1080/10253890.2019.1617691
发表时间：
2019
期刊：
Stress (Amsterdam, Netherlands)
影响因子：
0
作者：
Watanasriyakul,WTang;Normann,MarignyC;Akinbo,OreoluwaI;Colburn,William;Dagner,Ashley;Grippo,AngelaJ
通讯作者：
Grippo,AngelaJ

Voluntary physical exercise protects against behavioral and endocrine reactivity to social and environmental stressors in the prairie vole.

DOI：
10.1080/17470919.2017.1365761
发表时间：
2018-10
期刊：
Social neuroscience
影响因子：
2
作者：
Watanasriyakul WT;Wardwell J;McNeal N;Schultz R;Woodbury M;Dagner A;Cox M;Grippo AJ
通讯作者：
Grippo AJ

Social isolation and oxytocin antagonism increase emotion-related behaviors and heart rate in female prairie voles.

DOI：
10.1016/j.autneu.2022.102967
发表时间：
2022-05
期刊：
Autonomic neuroscience : basic & clinical
影响因子：
0
作者：
Watanasriyakul WT;Scotti ML;Carter CS;McNeal N;Colburn W;Wardwell J;Grippo AJ
通讯作者：
Grippo AJ

Behavioral and neuroendocrine consequences of disrupting a long-term monogamous social bond in aging prairie voles.

DOI：
10.1080/10253890.2020.1812058
发表时间：
2021-05
期刊：
Stress (Amsterdam, Netherlands)
影响因子：
0
作者：
Grippo AJ;McNeal N;Normann MC;Colburn W;Dagner A;Woodbury M
通讯作者：
Woodbury M

Social isolation alters central nervous system monoamine content in prairie voles following acute restraint.

社会隔离改变了草原田鼠在急性束缚后的中枢神经系统单胺含量。

DOI：
10.1080/17470919.2016.1276473
发表时间：
2018
期刊：
Social neuroscience
影响因子：
2
作者：
McNeal,Neal;Anderson,EdenM;Moenk,Deirdre;Trahanas,Diane;Matuszewich,Leslie;Grippo,AngelaJ
通讯作者：
Grippo,AngelaJ