Prairie voles as a novel model for the effects of pair bonds on aging

草原田鼠作为配对债券对衰老影响的新模型

• 批准号: 10458994
• 负责人: Karen L. Bales
• 金额: $ 75.18万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10458994
• 关键词: Adipose tissue; Adult; Affect; Age; Age-Months; Aging; Animal Model; Anxiety; Area; Behavior; Behavioral; Biological; Blood Pressure; Body Composition; Brain; Buffers; Caenorhabditis elegans; Cardiac; Cardiometabolic Disease; Cardiovascular system; Characteristics; Chronic stress; Cognition; Cognitive; Dementia; Development; Diabetes Mellitus; Disease; Distress; Emotional; Emotions; Family Relationship; Female; Foundations; Friendships; Gene Expression; Glucose; Goals; Grief reaction; Hand Strength; Health; Health Benefit; Heart; Heart Diseases; Hormones; Human; Hypothalamic structure; Impairment; Incidence; Individual; Infrastructure; Learning; Link; Lipids; Loneliness; Longevity; Marriage; Measures; Mediating; Memory; Mental Depression; Metabolic; Metabolic syndrome; Metabolism; Microtus; Modeling; Molecular; Muscular Atrophy; Neurohormones; Neurons; Neurosecretory Systems; Organ; Outcome; Oxytocin; Oxytocin Receptor; Pair Bond; Parents; Partner in relationship; Performance; Peripheral; Pharmacology; Physiology; Plasma; Play; Population; Psychological Stress; Research Personnel; Rodent; Rodent Model; Role; Same-sex; Siblings; Skeletal Muscle; Social Conditions; Social Interaction; Social isolation; Social support; Stimulus; Stress; System; Testing; Time; Tissues; Touch sensation; Variant; Work; behavior test; behavioral impairment; blood pressure reduction; cardiometabolism; cardiovascular disorder risk; cognitive function; depressive symptoms; frailty; glucose tolerance; healthspan; healthy aging; hypothalamic-pituitary-adrenal axis; improved; indexing; insight; male; mortality; neurophysiology; novel; offspring; prairie vole; preference; receptor; receptor binding; response; sex; social; social attachment; social relationships; social stress; stressor; stroke risk; young adult

Project Summary Social relationships are crucially important to human health. The effects of social relationships on healthy aging are seen in several systems, including the cardiovascular system, metabolism, emotion, and cognitive function. The effects of social isolation and loneliness have been shown to independently increase risk for stroke, heart disease, and overall mortality. High quality social support, in contrast, can play a positive role in healthy aging including reducing metabolic syndrome and adverse cardiovascular outcomes. Long-term partnerships (such as marriage) are the primary close relationship in many adults, but other types of relationships such as sibling relationships, other family relationships, and friendships, may also support healthy aging. Prairie voles are an excellent rodent model of social relationships, in that they show classic behavioral characteristics of an attachment bond: adult males and females form pair bonds, which are characterized by a preference for the familiar partner, distress upon separation, and the ability of the partner to provide a social buffer against stress. These behavioral characteristics in prairie voles provide researchers with the ability to examine the effects of specific types of affiliative relationships (pair mates, siblings, parent-offspring) in adult males as well as in females. The hormone oxytocin has been established as a foundational mechanism in the neurophysiology of relationship formation, relationship quality and partner loss. Its secretion is stimulated by a wide variety of social stimuli, including social touch, sex and social stress. Its receptor is widespread throughout the body. As such, it presents a potential unifying mechanism for organismal-scale effects of social relationships on the brain and the body. Here we will examine how long-term social relationships influence cardiac, metabolic, cognitive and emotional health across the lifespan. Our general approach is to use prairie voles, both males and females, in differing social conditions (pair-bonded, housed with same-sex sibling, or isolated) to examine the effects of presence of a relationship, type of that relationship, and quality of that relationship on cardiac and metabolic health, behavioral and cognitive health, and longevity. We will longitudinally assess measures of cardiac, metabolic, behavioral, and cognitive function at three timepoints: 6, 18, and 24 months of age. We will assess changes in the OT system across aging, on both brain and peripheral tissues (heart, adipose tissue, and skeletal muscle). Finally, we will explore how relationships change over time, and how loss of a partner affects healthy aging.

项目概要 社会关系对人类健康至关重要。社会关系对人的影响 健康衰老存在于多个系统中，包括心血管系统、新陈代谢、情绪和 认知功能。社会孤立和孤独的影响已被证明会独立增加 中风、心脏病和总体死亡率的风险。相比之下，高质量的社会支持可以发挥积极的作用 在健康老龄化中的作用，包括减少代谢综合征和不良心血管结局。长期 伙伴关系（例如婚姻）是许多成年人的主要亲密关系，但其他类型的 兄弟姐妹关系、其他家庭关系和友谊等关系也可能支持健康 老化。 草原田鼠是社会关系的优秀啮齿动物模型，因为它们表现出经典的行为 依恋关系的特征：成年男性和女性形成配对关系，其特征是 对熟悉伴侣的偏好、分离时的痛苦以及伴侣提供社交的能力 缓冲压力。草原田鼠的这些行为特征使研究人员能够 检查特定类型的亲缘关系（配偶、兄弟姐妹、亲子关系）对成人的影响 男性和女性一样。催产素激素已被确立为催产素的基本机制。 关系形成、关系质量和伴侣丧失的神经生理学。它的分泌受到刺激 各种各样的社会刺激，包括社会接触、性和社会压力。其受体广泛 遍布全身。因此，它为社会的有机规模效应提供了一个潜在的统一机制。 大脑和身体的关系。 在这里，我们将研究长期的社会关系如何影响心脏、代谢、认知和 整个生命周期的情绪健康。我们的一般方法是使用雄性和雌性草原田鼠 不同的社会条件（配对、与同性兄弟姐妹同住或隔离）来检查 某种关系的存在、该关系的类型以及该关系对心脏和代谢的影响的质量 健康、行为和认知健康以及长寿。我们将纵向评估心脏、 三个时间点的代谢、行为和认知功能：6、18 和 24 个月龄。我们将评估 随着年龄的增长，大脑和周围组织（心脏、脂肪组织和 骨骼肌）。最后，我们将探讨关系如何随着时间的推移而变化，以及失去伴侣会如何影​​响 健康老龄化。