THE NEURAL BASIS OF PAIR-BONDING IN FEMALE TITI MONKEYS

雌性蒂蒂猴配对的神经基础

基本信息

批准号：
9332064
负责人：
Karen L. Bales
金额：
$ 63.43万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-07-14 至 2022-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9332064
关键词：
Address Adolescent Adult Affect Amino Acid Sequence Area Behavioral Paradigm Biology Blood Buffers Callithrix Cell model Coronary heart disease Data Development Diagnosis Distress Epigenetic Process Exhibits Fathers Female Functional Imaging Goals Health Hormones Human Hypothalamic structure Image Impairment Individual Investigation Knowledge Laboratories Loneliness Maintenance Major Depressive Disorder Mental disorders Meta-Analysis Methylation Microtus Modeling Molecular Monkeys Mood Disorders Neurobiology Neuropeptide Receptor Neuropeptides Night Monkey Opioid Oxytocin Oxytocin Receptor Pair Bond Parents Partner in relationship Pharmacology Phylogenetic Analysis Primates Psychopathology Research Risk Risk Factors Rodent Rodent Model Role Saguinus Schizophrenia Series Social Behavior Social Behavior Disorders Social support Stroke System Techniques Vasopressin Receptor Vasopressins autism spectrum disorder base behavioral pharmacology behavioral study biological adaptation to stress dopamine system glucose uptake interest male methylation pattern offspring prairie vole preference receptor receptor function relating to nervous system response sex social social attachment social stress stress management study population tool trait

项目摘要

Project Summary The neurobiology of social behavior is of crucial importance not only in order to understand our own basic biology, but also for cases in which social behavior is impaired (for example, autism spectrum disorder and schizophrenia). The effects of social support on long-term health are now largely undisputed; and the dangers of loneliness are also increasingly well-recognized. For instance, a recent meta-analysis found that poor social relationships led to 29% increased risk for coronary heart disease, and a 32% increased risk for stroke. Our own prior investigations on the neurobiology of primate social bonds, like many others, have focused on males. Females represent a crucial and under-studied population when it comes to both psychiatric disorders of social behavior and studies of primate pair-bonding. Females are also more likely to be diagnosed with affective disorders, such as major depressive disorder, which may have critically understudied social risk factors, such as social stress. Here we propose a series of investigations into the neurobiological basis of attachment in female titi monkeys, a socially monogamous New World primate, using pharmacology and functional imaging to address fundamental questions about the substrates for sociality. Our overarching hypothesis is that the transition from attachment to parents to attachment to a pair-mate, may rely on neuropeptide receptor function, particularly the neuropeptides oxytocin and vasopressin. We will study these questions in adolescent and adult female titi monkeys. We will use behavioral pharmacology to investigate the effects of oxytocin and vasopressin manipulation on the fundamental traits of an attachment (preference for the partner/parent, distress upon separation, and social buffering). We use functional imaging to examine dynamic changes in glucose uptake in areas that we know to have oxytocin or vasopressin receptors in titi monkeys, in response to manipulations including the presence or absence of an attachment figure. Finally, we will use molecular techniques to examine changes in methylation of the oxytocin and vasopressin receptors across the course of pair-bonding, separation, and buffering from stress.

项目摘要社会行为的神经生物学不仅为了理解我们自己的基本生物学，也是在社会行为受损的情况下（例如自闭症谱系障碍和精神分裂症）。现在，社会支持对长期健康的影响基本上是无可争议的。和危险孤独感越来越被认可。例如，最近的一项荟萃分析发现社会差关系导致29％的冠心病风险增加，中风风险增加了32％。我们的像许多其他人一样，对灵长类动物社会纽带的神经生物学的先前调查都集中在男性上。当涉及到社会的两种精神疾病时，女性代表着一个至关重要的人群灵长类动物配对的行为和研究。女性也更有可能被诊断出患有情感疾病，例如重度抑郁症，可能已经严格研究了社会风险因素，例如作为社会压力。在这里，我们提出了一系列对依恋神经生物学基础的研究雌性titi猴子是一种具有药理学和功能成像的社会一夫一妻制的新世界灵长类动物解决有关社会基础的基本问题。我们的总体假设是从附着到父母到成对伴侣的依恋，可能依赖于神经肽受体功能，特别是神经肽催产素和加压素。我们将在青少年和成年雌性titi猴子。我们将使用行为药理学研究催产素和对附件的基本特征的血管加压素操纵（偏爱伴侣/父母，分离时的困扰和社会缓冲）。我们使用功能成像检查动态变化在我们知道在山猴中具有催产素或加压素受体的区域的葡萄糖摄取，以响应于操纵包括存在或不存在依恋图。最后，我们将使用分子在整个过程中检查催产素和加压素受体的甲基化变化的技术配对键，分离和从应力中缓冲。