Learning and Adaptation in Primary Visual Cortex

初级视觉皮层的学习和适应

• 批准号: 6886122
• 负责人: Andrew Franklin Teich
• 金额: $ 3.51万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6886122
• 关键词: Macaca mulatta; behavior test; behavioral /social science research tag; direct cortical response; environmental adaptation; lateral geniculate body; learning; molecular psychobiology; neural plasticity; neuroeffector; neuronal guidance; neurons; neuropsychological tests; predoctoral investigator; restraint; visual cortex; visual feedback; visual fields; visual pathways; visual perception; visual threshold; visual tracking

DESCRIPTION (provided by applicant): The goal of this proposal is to investigate the mechanism by which learning and adaptation can alter the orientation tuning of neurons in primary visual cortex. Learning to discriminate small changes in the orientation of a bar has been shown to sharpen the orientation tuning curves of cells whose preferred orientation is near the bar's orientation, while adapting to an oriented grating has been shown to broaden the tuning curves and shift the tuning curve peaks of cells whose preferred orientation is near the adapted orientation. Understanding these phenomena will contribute to our understanding of neuronal processing, which will play a critical role in both clinical and basic neuroscience in the twenty-first century. The goal of Specific Aim 1 is to determine whether modifying intracortical connections is necessary and sufficient for simulating learning and adaptation in a network where the feed-forward input from the lateral geniculate nucleus is sharply tuned for orientation, and will be accomplished by building on past modeling efforts. The goal of Specific Aim 2 is to experimentally test the prediction that adaptation in alert, non-anesthetized subjects causes physiological changes that are a transient version of the changes seen in learning.

描述（由申请人提供）：该提案的目的是研究学习和适应可以改变主视觉皮层中神经元的方向调整的机制。已经证明，学习区分钢筋方向的小变化，可以锐化其优选方向的细胞的取向调谐曲线，同时显示出对定向的栅格的适应性，已显示出可以扩大调谐曲线并改变其优选方向接近适应方向的细胞的调谐曲线。了解这些现象将有助于我们对神经元处理的理解，这将在二十一世纪的临床和基本神经科学中发挥关键作用。特定目的1的目的是确定修改物质内连接是否需要且足以模拟网络中的学习和适应，在网络中，从侧向基核的进料向前向输入进行了彻底调整以取向方向，并且可以通过在过去的建模工作上构建来实现。特定目的2的目的是实验测试预测，即在警报，非麻省理学科中适应会导致生理变化，这是学习中所见变化的短暂版本。