Learning and Adaptation in Primary Visual Cortex

初级视觉皮层的学习和适应

• 批准号: 6886122
• 负责人: Andrew Franklin Teich
• 金额: $ 3.51万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6886122
• 关键词: Macaca mulatta; behavior test; behavioral /social science research tag; direct cortical response; environmental adaptation; lateral geniculate body; learning; molecular psychobiology; neural plasticity; neuroeffector; neuronal guidance; neurons; neuropsychological tests; predoctoral investigator; restraint; visual cortex; visual feedback; visual fields; visual pathways; visual perception; visual threshold; visual tracking

DESCRIPTION (provided by applicant): The goal of this proposal is to investigate the mechanism by which learning and adaptation can alter the orientation tuning of neurons in primary visual cortex. Learning to discriminate small changes in the orientation of a bar has been shown to sharpen the orientation tuning curves of cells whose preferred orientation is near the bar's orientation, while adapting to an oriented grating has been shown to broaden the tuning curves and shift the tuning curve peaks of cells whose preferred orientation is near the adapted orientation. Understanding these phenomena will contribute to our understanding of neuronal processing, which will play a critical role in both clinical and basic neuroscience in the twenty-first century. The goal of Specific Aim 1 is to determine whether modifying intracortical connections is necessary and sufficient for simulating learning and adaptation in a network where the feed-forward input from the lateral geniculate nucleus is sharply tuned for orientation, and will be accomplished by building on past modeling efforts. The goal of Specific Aim 2 is to experimentally test the prediction that adaptation in alert, non-anesthetized subjects causes physiological changes that are a transient version of the changes seen in learning.

描述（由申请人提供）：该提案的目标是研究学习和适应可以改变初级视觉皮层神经元方向调整的机制。学习辨别条方向的微小变化已被证明可以锐化其首选方向接近条方向的细胞的方向调谐曲线，而适应定向光栅已被证明可以加宽调谐曲线并移动调谐曲线其首选方向接近适应方向的细胞的峰值。了解这些现象将有助于我们理解神经元处理，这将在二十一世纪的临床和基础神经科学中发挥关键作用。具体目标 1 的目标是确定修改皮质内连接对于模拟网络中的学习和适应是否是必要和充分的，其中来自外侧膝状核的前馈输入针对方向进行了急剧调整，并将通过建立在过去的基础上来完成建模工作。具体目标 2 的目标是通过实验测试以下预测：警觉的、非麻醉的受试者的适应会导致生理变化，这些变化是学习中所见变化的短暂版本。