A Collaborative Genomic Study of Bipolar Disorder

双相情感障碍的合作基因组研究

• 批准号: 6982758
• 负责人: Francis J McMahon
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6982758
• 关键词: behavioral genetics; bipolar depression; clinical research; family genetics; genetic mapping; genetic markers; genetic susceptibility; genome; genotype; human subject; interview; linkage disequilibriums; single nucleotide polymorphism

Since 1988 the NIMH Genetics Initiative has supported a national resource for the study of bipolar disorder (BP). By 1997 153 multiplex families were assessed, providing cell lines, DNA, and anonymized clinical data. This is now a publicly available resource and analytic results have been published. A second effort commenced in 1998 to ascertain 500 new BP sib pairs and this goal has been exceeded with 523 additional BPI sib pairs ascertained, interviewed, and a DNA sample collected. A genome wide scan has been completed at the Center for Inherited Disease Research (CIDR) on 237 sib pair families and the remaining 309 families was genotyped by CIDR during 2003. This resource, the largest of its kind, has revealed evidence for areas of linkage on chromosomes 6q and 17q. It has also provided confirmation of a locus on chromosome 22q and support for areas on 1p, 10p, 16p, 13q, and 21q. Accumulating linkage data has implicated other chromosomal regions. This extension of the national genetic resource will include a sample of 5000 unrelated BP probands and 2000 parents for case-control, and family-based association studies. Control samples will be obtained through the NIMH Genetics Initiative national resource. Probands and parents will be ascertained and assessed at eleven sites (the ten sites previously participating plus Howard University, which will provide African-American probands). Parental DNAs in a subsample will allow control for ethnic stratification. This sample will be a national resource for fine scale linkage disequilibrium mapping within regions of linkage, as well as candidate gene association studies.

自1988年以来，NIMH遗传学倡议支持了躁郁症研究的国家资源（BP）。到1997年，评估了153个多重家族，提供细胞系，DNA和匿名临床数据。现在，这是一种公开可用的资源，并且已经发布了分析结果。 1998年开始了第二次努力，以确定500个新的BP SIB对，并且该目标已超过523个额外的BPI SIB对确定，采访，并收集了DNA样本。基因组广泛的扫描已在遗传性疾病研究中心（CIDR）对237个SIB对家族进行，其余309个家族是由CIDR在2003年期间进行的。该资源是此类资源，这是同类资源中的最大资源，它揭示了关于染色体6q和17q染色体上连接领域的证据。它还提供了对22q染色体染色体上的基因座的确认，并为1p，10p，16p，13q和21q的面积提供了支持。累积的连锁数据牵涉到其他染色体区域。国家遗传资源的这种扩展将包括5000个无关的BP概率和2000年的病例控制父母和基于家庭的协会研究的样本。控制样本将通过NIMH遗传学计划国家资源获得。将在11个地点（以前参与的十个站点加霍华德大学（将为非裔美国人的证据）中确定和评估证据和父母。子样本中的父母DNA将允许控制种族分层。该样本将是在连锁区域内以及候选基因协会研究中进行精细链接不平衡映射的国家资源。