MOLECULAR GENETIC STUDIES OF BIPOLAR DISORDER

双相情感障碍的分子遗传学研究

• 批准号: 2415787
• 负责人: Francis J McMahon
• 金额: $ 15.57万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-05-01 至 2001-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2415787
• 关键词: autoradiography; behavioral /social science research tag; behavioral genetics; bipolar depression; chromosomes; clinical research; family genetics; genetic markers; genetic polymorphism; genotype; human data; human genetic material tag; linkage mapping; mitochondrial DNA; polymerase chain reaction; single strand conformation polymorphism

This SDAC will provide me with the additional training and skills I need to become an independent investigator in the genetics of bipolar affective disorder (BPAD). The proposed career development plan aims to extensively develop my skills in molecular genetic methods. Courses and workshops in genetic epidemiology, linkage, and association analysis will complement laboratory training in molecular genetic techniques. J. Raymond DePaulo, Kirby Smith, and Douglas C. Wallace will serve as preceptors. The training program will be enhanced by a research plan aimed at investigating the potential role that loci located on chromosome 18 and within the mitochondrial genome play in the etiology of BPAD. Both regions are implicated by prior data as potential sites of BPAD susceptibility loci. I plan to examine a defined region on chromosome 18 for microsatellite marker alleles in linkage disequilibrium with bipolar I disorder (BPI). The region I will examine has been implicated by two independent genetic linkage studies. As a parallel aim, I will screen the 16.5 kilobase mitochondrial genome for polymorphisms associated with (BPI). Both projects are types of family-based association studies. The sample will consist of BPI probands and their relatives already ascertained and clinically evaluated at Johns Hopkins. This integrated career development and research program will provide me with the expertise essential for fulfilling my long-term career goal of identifying and studying genes that play an important role in BPAD and other major mental illnesses.

这个SDAC将为我提供我需要的其他培训和技能 成为双极情感遗传学的独立研究者 疾病（BPAD）。 拟议的职业发展计划旨在广泛 发展我在分子遗传方法方面的技能。 课程和讲习班 遗传流行病学，联系和关联分析将补充 分子遗传技术实验室培训。 J. Raymond DePaulo， 柯比·史密斯（Kirby Smith）和道格拉斯·C·华莱士（Douglas C. Wallace）将作为受体。 针对的研究计划将增强培训计划 研究基因座在18号染色体和 在BPAD病因中的线粒体基因组中发挥作用。 两个都 区域被先前的数据与BPAD的潜在位点有关 敏感位点。 我计划检查染色体18的定义区域 对于链接不平衡的微卫星标记等位基因与双极性 我混乱（BPI）。 我要检查的区域已被两个 独立的遗传联系研究。 作为平行目的，我将筛选 16.5千个酶线粒体基因组，用于与 （BPI）。 这两个项目都是基于家庭的协会研究的类型。 这 样本将包括BPI检验及其亲戚 在约翰·霍普金斯（Johns Hopkins）进行了确定和临床评估。 这个综合的职业发展和研究计划将为我提供 具有实现我长期职业目标至关重要的专业知识 识别和研究在BPAD和 其他主要的精神疾病。