NEUROPATHOLOGY CORE

神经病理学核心

• 批准号: 6797490
• 负责人: CAROL A MILLER
• 金额: $ 7.99万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6797490
• 关键词: Alzheimer' s disease; biomedical facility; cerebrovascular disorders; histopathology; human tissue; neuropathology; patient oriented research; tissue /cell preparation; tissue /organ preservation

The Pathology Core provides tissue diagnoses of Alzheimer's disease (AD), cerebrovascular disease (CVD) and related dementias and links the clinical studies with basic research by project-driven tissue procurement and allocation. The diagnostic protocol integrates components of the CERAD program and Braak and Braak parameters recommendeq by the NIA-Reagan Institute Workshop Group and the IVD program project protocol. During the current funding period, the Core played an integral role in project design, serving a total of 41 funded investigators conducting 43 projects yielding 44 publications in peer review journals, and 42 abstracts. In the renewal, projects of 26 investigators located at 8 academic centers emphasize oxidant stress, CVD, hypoxia/ischemia, Abeta, sex hormones, inflammation, an? aging. Tissues are mainly obtained from patients enrolled in the USC Clinical Core, Spanish-Speaking Satellite, and from the USC Anatomical Gift Program. Neuropathology correlates will be available for future extensions of Projects 1 and 3.A 24-hour autopsy service minimizes post-mortem delay and insures high-fidelity preparation for biochemistry, molecular biology, RNA expression. The Core provides reliable neuroanatomical dissections and secialized tissue preparations (e.g., "fresh" tissue for 9 studies). The Core will also coordinate genotyping for risk factors (e.g., ApoE) from post-mortem tissue, as well as from blood samples obtained by the Clinical Core, Spanish Speaking Satellite, ant Project 2. Currently, clinical information including dementia severity and neuropathology diagnostic data are accessible online through the ADRC website. Neuropathological data is shared on an ongoing basis with the National Alzheimer's Coordinating Center (NACC).

病理学核心提供阿尔茨海默病 (AD)、脑血管疾病 (CVD) 和相关痴呆症的组织诊断，并通过项目驱动的组织采购和分配将临床研究与基础研究联系起来。该诊断协议集成了 CERAD 计划的组成部分以及 NIA-里根研究所研讨会小组推荐的 Braak 和 Braak 参数以及 IVD 计划项目协议。在当前资助期间，核心在项目设计中发挥了不可或缺的作用，总共为 41 名受资助的研究人员提供服务，开展了 43 个项目，在同行评审期刊上发表了 44 篇出版物和 42 份摘要。在更新中，分布在 8 个学术中心的 26 位研究人员的项目强调氧化应激、CVD、缺氧/缺血、Abeta、性激素、炎症、和？老化。组织主要来自参加南加州大学临床核心、西班牙语卫星和南加州大学解剖礼品计划的患者。神经病理学关联将可用于项目 1 和 3 的未来扩展。24 小时尸检服务最大限度地减少尸检延迟，并确保生物化学、分子生物学、RNA 表达的高保真准备。核心提供可靠的神经解剖学解剖和专业化的组织准备（例如，用于 9 项研究的“新鲜”组织）。该核心还将协调来自死后组织以及临床核心、西班牙语卫星、蚂蚁项目 2 获得的血液样本的风险因素（例如 ApoE）的基因分型。目前，临床信息包括痴呆症严重程度和神经病理学诊断数据可通过 ADRC 网站在线获取。神经病理学数据与国家阿尔茨海默病协调中心 (NACC) 持续共享。