Neuropathology Core

神经病理学核心

• 批准号: 10247457
• 负责人: CAROL A MILLER
• 金额: $ 34.08万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10247457
• 关键词: 3-Dimensional; Address; Alzheimer' s Disease; Alzheimer' s disease diagnosis; Alzheimer' s disease related dementia; Amyloid beta-Protein; Animal Disease Models; Animal Model; Apolipoprotein E; Autopsy; Award; Basic Science; Behavioral; Biological Markers; Biological Models; Blood; Blood - brain barrier anatomy; Blood Vessels; Blood capillaries; Blood specimen; Brain; Cells; Cerebrospinal Fluid; Cerebrovascular Disorders; Cerebrovascular system; Clinical; Clinical Research; Collaborations; Complex; Consent; Data; Databases; Dementia; Diagnosis; Diagnostic; Disease; Disease model; Education; Electrical Stimulation of the Brain; Ethnic Origin; Etiology; Evaluation; Extravasation; Frontotemporal Dementia; Genetic Diseases; Genetic Research; Genetic study; Genotype; Goals; Human; Image; Individual; Injury; Institutes; Label; Laboratories; Lewy Bodies; Light; Link; Methods; Microscopic; Molecular; Molecular Genetics; Neurobiology; Neurologic; Neurologist; Pathogenesis; Pathology; Patients; Pilot Projects; Preparation; Psychometrics; Radiology Specialty; Regenerative Medicine; Research; Research Personnel; Resolution; Resource Sharing; Retina; Risk Factors; Rodent Model; Role; Sampling; Structure; System; Tissue Donations; Tissue Sample; Tissue imaging; Tissues; Training; Training and Education; Translational Research; accurate diagnosis; base; blood product; brain research; cerebrovascular; data management; design; ethnic diversity; genetic analysis; genetic risk factor; genomic data; glymphatic system; human tissue; improved; in vivo; induced pluripotent stem cell; molecular marker; neuroimaging; neuropathology; neurovascular injury; neurovascular unit; novel; novel strategies; novel therapeutics; outreach; public education; recruit; regenerative approach; relating to nervous system; research study; statistics; symposium; translational approach; two-photon; vascular risk factor

ABSTRACT: Core D Neuropathology Alzheimer's disease (AD) is a multifactorial and complex disease and includes the impact of the cerebrovascular system on the induction and progression of the dementia. Correlation of experimental findings in disease models with the changes in the human CNS can now be approached with cellular, molecular and genetically related molecular markers. System connectivity is now approached three-dimensionally using novel methods of cellular labeling of animal model or human tissues combined with imaging, as seen with CLARITY-based preparations viewed with two-photon or lightsheet imaging. In AIM 1 the Neuropathology Core serves these functions by providing at autopsy, CNS tissues for accurate diagnoses of AD and accompanying pathologies. AIM 2 provides individual and multiple investigators with diseased tissues, blood, blood products and CSF for research. Contribution to a common database in AIM 3 serves to correlate neurological, psychometric, neuroimaging and behavioral data with the neuropathological and molecular findings. It also coordinates contribution of tissues, blood and cerebrospinal fluid (CSF) to national initiatives that also define genomic data, such as ApoE and other risk factors, and biomarker information addressed in AIMS 4-6, that highlight those functional in the neurovascular unit and in the blood-brain-barrier, and the recently described “glymph” system. In AIM 7, training and education of neuropathologists, neurologists, and neuroscientists bring AD and related dementia further into focus by defining the potential translational approaches leading to novel therapies.

摘要：核心 D 神经病理学 阿尔茨海默病 (AD) 是一种多因素的复杂疾病，包括以下因素的影响： 脑血管系统与痴呆诱发和进展的相关性。 疾病模型中的实验结果随人类中枢神经系统的变化而变化，现在可以 使用细胞、分子和遗传相关的分子标记系统进行处理。 现在使用新的细胞标记方法来实现三维连接 动物模型或人体组织与成像相结合，如基于 CLARITY 的结果 在 AIM 1 神经病理学核心中使用双光子或光片成像观察制剂。 通过在尸检中提供 CNS 组织来实现这些功能，以准确诊断 AD 和 AIM 2 为个体和多个研究者提供患病情况。 组织、血液、血液制品和脑脊液用于研究的共同数据库。 AIM 3 用于将神经心理测量、神经影像和行为数据与 它还协调组织、血液的贡献。 和脑脊液 (CSF) 到也定义基因组数据的国家计划，例如 ApoE 以及 AIMS 4-6 中提到的其他风险因素和生物标志物信息，强调了这些因素 在神经血管单元和血脑屏障中发挥功能，以及最近描述的 在 AIM 7 中，对神经病理学家、神经科医生和患者进行培训和教育。 神经科学家通过定义潜力，进一步关注 AD 和相关痴呆症 转化方法带来新的疗法。