CORE--BIOSTATISTICS AND DATA MANAGEMENT

核心——生物统计和数据管理

• 批准号: 6798068
• 负责人: Steven Dyal Edland
• 金额: $ 14.34万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6798068
• 关键词: Alzheimer' s disease; biomedical facility; computer system design /evaluation; data collection methodology /evaluation; data management; information systems; longitudinal human study; psychometrics; statistics /biometry

The Biostatistics and Database Management Core will provide database and statistical support to the Mayo Alzheimer's Disease Research Center (ADRC) Projects and Cores. To this end, our specific aims are: Specific Aim 1. To develop and maintain a relational database housing the longitudinal clinical and neuropsychometric data gathered by the Clinical Core. Specific Aim 2. To provide database support and biostatistical consulting support to the Projects and Cores. Building upon the existing Mayo ADRC relational database structure, database management staff will expand the Clinical Core psychometric and clinical exam database to accommodate new forms introduced by the Clinical Core and new forms mandated by the NIA (the expanded standard clinical data set). Various improvements to our database will be implemented, including a web-based data element dictionary and electronic data audit capabilities. The Clinical Core database will be linked to imaging, genotype, neuropathology, and DNA and plasma inventory databases, and data management staff will support data requests by Core and Project investigators. Biostatisticians will support Core and Project investigators in study design, analysis, and interpretation. The Biostatistics and Database Management Core will provide database support and dedicated time for statistical consulting to all of the Cores and Projects. Sharing of database and statistical personnel will allow us to efficiently support various projects and ensure that biostatistical consultants familiar with Alzheimer's disease and with the details of the Mayo Clinic ADRC are available to Cores and Projects.

生物统计学和数据库管理核心将为数据库和统计支持提供 阿尔茨海默氏病研究中心（ADRC）项目和核心。为此，我们的 具体目的是： 特定目的1。开发和维护纵向的关系数据库 临床核心收集的临床和神经心理测量数据。 具体目的2。为数据库支持和生物统计咨询支持 项目和核心。 基于现有的Mayo ADRC关系数据库结构，数据库管理人员 将扩展临床核心心理测量和临床检查数据库，以适应NIA授权的临床核心和新形式引入的新形式（扩展的标准临床数据集）。将实施对数据库的各种改进，包括基于Web的数据元素词典和电子数据审核功能。临床核心数据库将与成像，基因型，神经病理学以及DNA和等离子体库存数据库相关，数据管理人员将支持Core和Project Reskovity的数据请求。生物统计学家将支持核心和项目研究人员在研究设计，分析和解释中。生物统计学和数据库管理核心将为所有核心和项目提供数据库支持和统计咨询的专用时间。数据库和统计人员的共享将使我们能够有效地支持各种项目，并确保熟悉阿尔茨海默氏病以及Mayo Clinic ADRC的详细信息可供核心和项目提供详细信息。