Data Management and Statistical Core

数据管理与统计核心

基本信息

批准号：
10407980
负责人：
Steven Dyal Edland
金额：
$ 28.93万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-05-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10407980
关键词：
Alzheimer&apos s Disease Biological Markers Blood Clinical Clinical Research Consult Consultations Data Data Analyses Data Security Databases Enrollment Ensure Evaluation Faculty Genetic Goals Health Sciences Indiana Individual Information Services Institutes Latino Leadership Medical Students Mentors Methodology Neurosciences Outpatients Participant Patient Recruitments Postdoctoral Fellow Procedures Protocols documentation Quality Control Registries Reporting Research Research Personnel Research Proposals Resources Secure Security Services Specimen Statistical Data Interpretation Statistical Methods System Tissue Sample Training Universities Update Work brain tissue cell repository clinical center clinical database computer center data management design education research follow-up graduate student induced pluripotent stem cell interest neuroimaging neuropathology novel outreach ranpirnase recruit statistics

项目摘要

DATA MANAGEMENT AND STATISTICAL CORE – SUMMARY/ ABSTRACT The Data Management and Statistics Core (the Data Core) provides statistical consulting, data management and information transfer resources to enhance the quality of Alzheimer’s disease research conducted by ADRC Core and affiliate investigators. This will be done by accomplishing the following goals: Aim 1) Provide database support to all Cores’ ADRC related research. The Core will coordinate the entry, quality control, management and analysis of data generated by the enrollment, evaluation, and follow up of outpatient and control subjects recruited by the Center’s Clinical Core, as well as coordinate the entry, quality control, management and analysis of data generated by the Center’s Neuropathology Core, and neuroimaging data generated by the Clinical Core and collaborating investigators. Standard enrollment reports will be generated monthly for ADRC leadership, specialized reports will be prepared as needed. The Core will communicate with San Diego Super Computer Center regularly to verify the security and integrity of the database. Aim 2) Provide and support a Registry database for the Clinical and the Outreach, Recruitment, and Engagement Cores. The Core will update the database functionality as needed, support data queries, and train staff in the use of the Registry. Aim 3) Prepare the ADRC database for routine submission to the National Alzheimer’s Coordinating Center (NACC), support new NACC procedures and initiatives, and resolve NACC queries. Aim 4) Provide statistical design and analysis consultation services to ADRC investigators. The Core will provide power calculations and statistical analysis plans for research proposals, and provide statistical programming and analyses for active research, developing novel statistical methods as required. Aim 5) The Core will educate investigators, trainees and junior faculty in the principles and use of statistical analysis methodologies.

数据管理和统计核心 - 摘要/摘要数据管理和统计核心（数据核心）提供统计咨询，数据管理和信息转移资源以提高阿尔茨海默氏病研究的质量由ADRC核心和会员研究人员进行。这将通过完成以下目标来完成：目标1）为所有核心的ADRC相关研究提供数据库支持。核心将协调条目，质量控制，管理和分析由入学，评估和随访产生的数据中心临床核心招募的门诊和控制对象，并协调条目，质量控制，管理和分析中心神经病理核心产生的数据和神经影像学临床核心和合作研究人员生成的数据。标准注册报告将是为ADRC领导每月生成，将根据需要准备专门的报告。核心意愿定期与圣地亚哥超级计算机中心沟通，以验证数据库。目标2）提供并支持临床和外展，招聘以及订婚核心。核心将根据需要更新数据库功能，支持数据查询和培训人员使用注册表。目标3）准备ADRC数据库，以使其常规提交给国家阿尔茨海默氏症协调中心（NACC），支持新的NACC程序和计划，并解决NACC 查询。目标4）向ADRC调查人员提供统计设计和分析咨询服务。核心将为研究建议提供电源计算和统计分析计划，并提供统计进行积极研究的编程和分析，根据需要开发新颖的统计方法。目标5）核心将教育研究人员，学员和初级教师的原则和使用统计分析方法论。