Metabolic Complication of HIV Infection

HIV 感染的代谢并发症

• 批准号: 6696204
• 负责人: Judith S. Currier
• 金额: $ 14.3万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6696204
• 关键词: AIDS therapy; HIV infections; adipose tissue; antiAIDS agent; atherosclerosis; blood glucose; body composition; cardiovascular disorder risk; clinical research; clinical trials; drug adverse effect; gender difference; human subject; insulin sensitivity /resistance; lipid metabolism; longitudinal human study; medical complication; metabolism disorder; patient oriented research; protease inhibitor

DESCRIPTION (provided by applicant): Over the next 5 years my career goals include (1) conducting original research on the epidemiology and impact of metabolic complications of HIV disease, (2) developing a comprehensive program to mentor trainees with career interests in patient-oriented research, (3) the expansion of my research program to include an international component. The rich diversity of ongoing basic and clinical research on HIV infection at UCLA and the facilities available in the Center for Clinical AIDS Research and Education provide tremendous resources to enhance my experience as a clinical investigator and provide a stimulating atmosphere for my trainees. The K24 Award will help me to achieve my career goals by providing me with a significant amount of protected time to devote to mentoring my trainees, gaining additional training for myself in biostatistics and focusing on my own research program. This application describes a comprehensive training program for fellows, which includes formal training in biostatistics and clinical research methods. In addition four research projects are described. The proposed research will investigate the natural history of insulin resistance among a cohort of well-characterized patients on long term HAART and examine in detail gender differences in prevalence of insulin resistance and lipid abnormalities in men and women enrolled in a cross-sectional study of metabolic complications. A prospective, matched, cohort study will compare measurements of carotid intima medial thickness between patients with HIV infection treated with a protease inhibitor or no therapy to patients without HIV infection in order to test the hypothesis that protease inhibitor therapy is associated with an increased risk of subclinical atherosclerosis. A randomized clinical trial comparing three antiretroviral regimens among subjects enrolled at twelve sites located in resource poor settings around the world will provide the opportunity to examine the factors associated with the development of immune reconstitution syndromes and to determine whether these syndromes predict an altered response to HAART. The strong support from my Division Chief and Department Chair to allow me to reduce my clinical and administrative responsibilities will greatly facilitate my success in achieving my goals.

描述（由申请人提供）：在接下来的 5 年里，我的职业目标包括 (1) 对艾滋病毒疾病的流行病学和代谢并发症的影响进行原创研究，(2) 制定一项综合计划，指导对患者职业感兴趣的学员-面向研究，(3) 扩展我的研究计划以包括国际部分。加州大学洛杉矶分校正在进行的有关艾滋病毒感染的基础和临床研究的丰富多样性以及临床艾滋病研究和教育中心提供的设施提供了大量资源，以增强我作为临床研究者的经验，并为我的学员提供激励的氛围。 K24 奖将为我提供大量受保护的时间来专门指导我的学员、为我自己获得生物统计学方面的额外培训以及专注于我自己的研究项目，从而帮助我实现职业目标。该应用程序描述了研究员的综合培训计划，其中包括生物统计学和临床​​研究方法的正式培训。此外还描述了四个研究项目。拟议的研究将调查一组长期接受 HAART 的特征明确的患者中胰岛素抵抗的自然史，并详细检查参加一项代谢横断面研究的男性和女性胰岛素抵抗和血脂异常患病率的性别差异。并发症。一项前瞻性、匹配的队列研究将比较接受蛋白酶抑制剂治疗或未接受治疗的 HIV 感染患者与未感染 HIV 的患者颈动脉内膜中层厚度的测量结果，以检验蛋白酶抑制剂治疗与颈动脉风险增加相关的假设。亚临床动脉粥样硬化。一项随机临床试验比较了世界各地资源匮乏地区 12 个地点的受试者的三种抗逆转录病毒治疗方案，该试验将提供机会检查与免疫重建综合征发生相关的因素，并确定这些综合征是否预示着对 HAART 反应的改变。我的科长和系主任的大力支持使我能够减少我的临床和行政职责，这将极大地促进我成功实现我的目标。