ACTIVE AND NONLINEAR MODELS FOR COCHLEAR MECHANICS

耳蜗力学的主动和非线性模型

• 批准号: 6634496
• 负责人: Karl Grosh
• 金额: $ 18.19万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2005-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6634496
• 关键词: cochlea; computational neuroscience; ear hair cell; hearing; organ of Corti

In order to better understand the hearing process, numerous efforts in cochlear modeling and physiological measurement have been undertaken. Understanding the process of normal auditory function holds the significant promise of assisting in the determination of the causes of hearing loss and tinnitus. Understanding the morphology and function of each component can lead the way to the development of better cochlear prostheses and diagnostic processes for noninvasive determination of disease. Biologically inspired designs for speech recognition and signal processing of non--auditory systems are also possible and could have a significant impact for applications other than hearing. Current research in cochlear mechanics is focussed on determining the source of the enhanced filtering and nonlinear compression seen in in vivo measurements. The hypothesis that an active amplification process is the source of the enhanced filtering has been studied widely since first proposed in 1948. In this grant a comprehensive, efficient numerical strategy for nonlinear and active macroscopic cochlear mechanics is proposed. Through this capability, a virtual laboratory for model testing will be developed capable of incorporating the most general nonlinear models for activity and geometric nonuniformity. Using a hybrid analytic and numeric approach the micromechanics of the Organ of Corti, especially the outer hair cells and their connecting structures, will be included in the global response modeling. These predictions will be compared to in vivo data obtained from physiological experiments. Experimental validation is a central focus of this modeling effort. Close ties to the physiological measurements is important to validate modeling parameters, most importantly the relation of the hypothesized transductions models to the endocochlear potential (or current). Controlled experiments will be used to both identify transducer model parameters (e.g., gains) and to validate/invalidate the hypothesis.

为了更好地理解听力过程，人们在耳蜗建模和生理测量方面做出了大量努力。 了解正常听觉功能的过程有助于确定听力损失和耳鸣的原因。了解每个组件的形态和功能可以引导开发更好的人工耳蜗和用于无创确定疾病的诊断过程。非听觉系统的语音识别和信号处理的受生物学启发的设计也是可能的，并且可能对听力以外的应用产生重大影响。目前耳蜗力学的研究重点是确定体内测量中所见的增强滤波和非线性压缩的来源。 自 1948 年首次提出以来，主动放大过程是增强滤波来源的假设已得到广泛研究。在这项资助中，提出了一种用于非线性和主动宏观耳蜗力学的全面、有效的数值策略。 通过这种能力，将开发一个用于模型测试的虚拟实验室，能够合并最通用的活动和几何不均匀性非线性模型。 使用混合分析和数值方法，柯蒂氏器的微观力学，特别是外毛细胞及其连接结构，将被纳入全局响应模型中。这些预测将与从生理实验获得的体内数据进行比较。 实验验证是该建模工作的核心焦点。 与生理测量的密切联系对于验证建模参数非常重要，最重要的是假设的转导模型与耳蜗内电位（或电流）的关系。 受控实验将用于识别传感器模型参数（例如增益）并验证/无效假设。