Implantable Transducer Systems for Auditory Prostheses

用于听觉假体的植入式换能器系统

• 批准号: 10825738
• 负责人: Karl Grosh
• 金额: $ 63.16万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-18 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10825738
• 关键词: Accelerometer; Acoustic Stimulation; Acoustics; Adoption; Affect; Age; Appearance; Auditory Prosthesis; Auditory system; Behavior; Bilateral Hearing Loss; Cadaver; Calibration; Cochlea; Cochlear Implants; Communication; Cosmetics; Critical Pathways; Cues; Deposition; Devices; Dimensions; Ear; Electronics; Elements; Engineering; Environmental Wind; European; Exhibits; External Ear; Face; Female; Film; Floor; Goals; Hearing; Hearing Aids; Human; Implant; Individual; Inherited; Intervention; Language Development; Letters; Location; Longevity; Mechanics; Middle Ear Implant; Motion; Noise; Operative Surgical Procedures; Output; Patients; Performance; Pharmacologic Substance; Population; Preparation; Procedures; Process; Prosthesis; Quality of life; Research; Research Personnel; Rotation; Safety; Sampling; Sensorineural Hearing Loss; Signal Transduction; Speech Perception; Sports; Surgical Disarticulation; System; Temporal bone structure; Testing; Theoretical model; Thinness; Tissues; Transducers; Translations; Tympanic membrane; Unilateral Hearing Loss; United States; Use Effectiveness; Weight; Work; analog; battery recharging; bone; conditioning; design; effectiveness evaluation; experience; external ear auricle; force sensor; hearing impairment; hearing restoration; implantation; implanted sensor; improved; integrated circuit; male; meetings; microphone; middle ear; middle ear fluid; milligram; minimally invasive; novel; performance tests; pressure; printed circuit board; prosthesis wearer; seal; sensor; sound; subcutaneous; usability; vibration; wireless

PROJECT SUMMARY: In this application, we seek to design, fabricate, and test implantable, packaged accelerometers that sense incoming sound by transducing the motion of the middle ear (ME) bones (ossicles). We will test the performance of these devices using benchtop calibration and quantification tests as well as using acoustic stimulation of accelerometers implanted in cadaveric temporal bone preparations. We seek to create a device that meets the stringent geometric, acoustic, weight, and power requirements for prostheses by using a multi- resonant (multi-band) piezoelectric-micro-electro-mechanical systems (piezo-MEMS) sensor co-designed with an application specific integrated circuit (ASIC) with addressable filtering and amplifying circuitry. A novel flip- chip packaging strategy is proposed which can deliver a 5-milligram piezo-MEMS-ASIC packaged device by eliminating the need for printed circuit board mounting. State-of-the-art thin piezoelectric film materials and deposition will be explored to further reduce the device size and improve performance. Separate, component- level piezo-MEMS die and ASIC testing in combination with system-level testing in a benchtop setting will enable characterization of the complete system. Tested sensor systems will be implanted in male and female cadaveric temporal bone samples, and the acoustic sensitivity and noise floor characterized. We will consider locations along the ossicular chain to reduce device impact on the ME mechanics, ease surgical implantation (minimize invasiveness), and maximize sensitivity (as the accelerometer is sensitive to both translation and rotation). The objective of this present application is to develop implantable sensors, because accomplishing this objective is a necessary step in achieving our long-term goal of a totally implantable auditory prosthesis (e.g., hearing aids and cochlear implants with all components housed invisibly). This line of research aims to provide new implantable options to treat hearing loss, thereby increasing the number of auditory prosthesis users by enhancing the usability, safety, cosmetic appeal, and performance of the device and improving patient quality of life.

项目概要： 在此应用中，我们寻求设计、制造和测试可感知的可植入封装加速度计 通过转换中耳 (ME) 骨骼（小骨）的运动来接收传入的声音。我们将测试 使用台式校准和量化测试以及声学来评估这些设备的性能 刺激植入尸体颞骨制剂中的加速度计。我们寻求创造一种设备 通过使用多种技术，满足假肢严格的几何、声学、重量和功率要求 谐振（多频带）压电微机电系统（piezo-MEMS）传感器与 具有可寻址滤波和放大电路的专用集成电路 (ASIC)。新颖的翻转—— 提出了芯片封装策略，可通过以下方式提供 5 毫克压电 MEMS-ASIC 封装器件： 无需安装印刷电路板。最先进的压电薄膜材料和 将探索沉积以进一步减小器件尺寸并提高性能。独立的组件- 压电 MEMS 芯片和 ASIC 测试与台式设置中的系统级测试相结合 能够对整个系统进行表征。经过测试的传感器系统将被植入男性和女性体内 尸体颞骨样本，以及声敏感性和本底噪声特征。我们会考虑 沿着听骨链的位置，以减少设备对 ME 力学的影响，简化手术植入 （最大限度地减少侵入性），并最大限度地提高灵敏度（因为加速度计对平移和平移都很敏感） 旋转）。本申请的目的是开发植入式传感器，因为实现 这一目标是实现完全植入式听觉假体长期目标的必要步骤 （例如，所有组件都隐藏在隐形状态的助听器和人工耳蜗）。该研究方向旨在 提供新的植入式选择来治疗听力损失，从而增加听觉假体的数量 通过增强设备的可用性、安全性、外观吸引力和性能并改进 患者的生活质量。