MOLECULAR NMR

分子核磁共振

• 批准号: 7102510
• 负责人: PETER D. EMANUEL
• 金额: $ 11.87万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-28 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7102510
• 关键词: biomedical facility; experimental designs; neoplasm /cancer; nuclear magnetic resonance spectroscopy; training

DESCRIPTION (provided by applicant): The Molecular NMR Shared Facility was one of the original shared facilities established by the Comprehensive Cancer Center to provide high quality sample analysis to the Center's faculty membership. The primary objectives of the facility are to provide "state-of-art" instrumentation for use by the Center members in their individual research programs and research related to the Center's Core Programs. The facility provides training and educational activities for faculty and staff to insure proper utilization of the resources available. In addition, the facility provides expertise in experimental design, sample preparation and technical support. During the previous funding period, 80% of the Facility usage was for Cancer Center members. These investigations conducted with facility resources involved work on the design and synthesis of various linkers for anticancer drugs, peptides and antibodies; structural characterization of drug-DNA complexes; studies on anticancer and antiviral proteins, such as interferon-tau; investigations on the HIV gp 160-mediated apoptosis of T cells; design and evaluation of Doxirubin-peptide conjugates for cancer treatments; Studies on the functional domains of scaffolding proteins; and the design, synthesis and analysis of nucleoside analogs of anticancer agents. The facility seeks to expand its ability to provide quality NMR analysis for all existing projects through upgrading existing instrumentation and increased services.

描述（由申请人提供）：分子NMR共享设施是综合癌症中心建立的原始共享设施之一，旨在为中心的教职员工提供高质量的样本分析。 该设施的主要目标是提供“最先进的”仪器，以供中心成员在其个人研究计划和与中心的核心计划有关的研究中使用。 该设施为教职员工提供培训和教育活动，以确保适当利用可用资源。 此外，该设施还提供了实验设计，样本准备和技术支持方面的专业知识。 在上一期的资金期间，癌症中心成员中有80％的设施使用情况。 这些调查是用设施资源进行的，涉及在设计和合成抗癌药物，肽和抗体的各种接头的工作；药物-DNA复合物的结构表征；研究抗癌和抗病毒蛋白，例如干扰素-TAU；对T细胞的HIV GP 160介导的凋亡的研究；黑霉素肽结合物进行癌症治疗的设计和评估；对脚手架蛋白的功能结构域的研究；以及抗癌药物核苷类似物的设计，合成和分析。 该设施试图通过升级现有工具和增加的服务来扩大其为所有现有项目提供高质量NMR分析的能力。