Animal Core Facility

动物核心设施

基本信息

批准号：
8813060
负责人：
BIN GUO
金额：
$ 40.7万
依托单位：
NORTH DAKOTA STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-03-01 至 2021-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8813060
关键词：
Address Advisory Committees Animal Experiments Animal Model Animals Area Biomedical Research Cancer Etiology Cell model Centers of Research Excellence Cessation of life Clinical Clinical Management Core Facility Detection Diabetes Mellitus Diagnostic Digestive System Disorders Early Diagnosis Early treatment Ensure Equipment Erlotinib Experimental Designs Faculty Fluorouracil Fostering Goals Housing Human Resources IACUC Individual Institutes Institution Investigation Kidney Diseases Leadership Leucovorin Malignant neoplasm of pancreas Mentors Methods Mission Mus National Cancer Institute National Institute of General Medical Sciences Nude Mice Pilot Projects Postdoctoral Fellow Recruitment Activity Regimen Regulation Research Research Infrastructure Research Personnel Research Support Resources Rodent Model Scientist Senior Scientist Services Solid Testing Therapeutic Therapeutic Agents Toxic effect Training Transgenic Model Translational Research United States United States National Institutes of Health Xenograft procedure animal care animal facility anticancer research base cancer diagnosis cancer therapy career fundamental research gemcitabine graduate student high standard improved instrumentation irinotecan mouse model novel novel therapeutics objective response rate oxaliplatin phase 3 study programs protocol development research study response standard of care translational study treatment strategy

项目摘要

__________________________________________________________________________________________ Project Summary (Animal Core Facility) To enhance basic and translational studies devoted to the detection and treatment of pancreatic cancer, and to strengthen biomedical research at NDSU, we propose to establish a COBRE with a research focus on developing new strategies for the early diagnosis and treatment of pancreatic cancer. The proposed Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer at NDSU will be initially comprised of four thematically interrelated projects, each directed by a Junior Investigator. The resources available through the Center, in particular the Animal Core, will allow the Junior Investigators to utilize state-of-the-art methods to study the efficacy and toxicity of new therapeutic agents using mouse orthotopic xenograft and KPC transgenic models of pancreatic cancer. The four projects, together with the proposed Administrative Leadership, Animal Core Facility, Pilot Projects, and new faculty recruits, will propel this highly integrated group towards our goal to develop a sustainable center focused on pancreatic cancer research. The proposed Animal Core Facility will facilitate coordinated access to high standard animal service including animal care and experiments. The long-term goal of the Animal Core is to strengthen our institution's biomedical research infrastructure. This goal will be accomplished by establishing a premiere core facility that provides husbandry and housing for animal models as well as research support for the investigation of relevant biomedical questions. The primary focus of the Core will be on pancreatic cancer research. However, once established, the Animal Core will provide an outstanding platform for addressing a wide range of biomedical questions. The Animal Core has the following Specific Aims. 1) Establish the Animal Core Facility to foster excellence in pancreatic cancer research by expanding, and enhancing the existing NDSU animal facility. We will achieve this aim by recruiting essential personnel (manager and technician) and procuring state of the art equipment and research instrumentation. 2) Provide services for the scientific and animal needs of the individual Junior Investigators, Pilot Project Investigators, New and Existing Faculty, Postdoctoral Fellows, and graduate students associated with the five- year COBRE project. The services from the Core will include animal care and experiments, training, protocol development, and enforcing IACUC regulation. 3) Build a long-term sustainable Animal Core Research Platform. The Animal Core Facility will enable NDSU and collaborating scientists (including graduating COBRE investigators and others) to strengthen research programs and, as a result, be more competitive. The Animal Core will promote and sustain productive, extramurally-supported careers in biomedical research. __________________________________________________________________________________________

__________________________________________________________________________________________ 项目概要（动物核心设施）加强致力于胰腺癌检测和治疗的基础和转化研究癌症，并加强 NDSU 的生物医学研究，我们建议建立一个 COBRE 进行研究专注于开发胰腺癌早期诊断和治疗的新策略。拟议的 NDSU 胰腺癌诊断和治疗策略中心最初将由以下人员组成：四个主题相关的项目，每个项目均由一名初级研究员指导。可通过以下途径获得的资源该中心，特别是动物核心，将允许初级研究人员利用最先进的方法使用小鼠原位异种移植和 KPC 转基因研究新治疗药物的功效和毒性胰腺癌模型。这四个项目，连同拟议的行政领导、动物核心设施、试点项目和新招募的教师将推动这个高度一体化的团队实现我们的目标建立一个专注于胰腺癌研究的可持续中心。拟议的动物核心设施将促进协调获得高标准动物服务，包括动物护理和实验。动物核心的长期目标是加强我们机构的生物医学研究基础设施。这一目标将通过建立一个提供畜牧业的首要核心设施来实现动物模型的住宿以及相关生物医学研究的研究支持问题。核心的主要重点将是胰腺癌研究。然而一旦成立， Animal Core 将为解决广泛的生物医学问题提供一个出色的平台。这 Animal Core 有以下具体目标。 1) 建立动物核心设施，通过扩大和促进胰腺癌研究的卓越发展加强现有的 NDSU 动物设施。我们将通过招募必要的人员来实现这一目标（经理和技术员）并采购最先进的设备和研究仪器。 2) 为个人初级研究人员的科学和动物需求提供服务，试点项目与五个相关的研究人员、新任和现有教师、博士后研究员和研究生年 COBRE 项目。核心的服务将包括动物护理和实验、培训、协议开发，并执行 IACUC 监管。 3）建立长期可持续的动物核心研究平台。动物核心设施将使 NDSU 和合作科学家（包括即将毕业的 COBRE 研究人员和其他人）加强研究计划，从而更具竞争力。动物核心将促进和维持生产力，生物医学研究领域的校外支持职业。 __________________________________________________________________________________________