Animal Models & Imaging Facility (AMIF)

动物模型

• 批准号: 10487415
• 负责人: Karen H Martin
• 金额: $ 5.48万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10487415
• 关键词: Address; Animal Cancer Model; Animal Disease Models; Animal Model; Animals; Area; Award; Biomedical Research; Cancer Biology; Cancer Model; Cancer Patient; Cells; Centers of Research Excellence; Clinical Research; Collaborations; Complex; Core Facility; Data Analyses; Development; Disease Progression; Education; Electron Spin Resonance Spectroscopy; Ensure; Equipment; Event; Experimental Designs; Extramural Activities; Flow Cytometry; Funding; Goals; Health; Image; Institution; Investments; Journals; Magnetic Resonance Imaging; Malignant Neoplasms; Mentors; Modeling; Monitor; Neoplasm Metastasis; Optics; Patients; Postdoctoral Fellow; Pre-Clinical Model; Procedures; Process; Program Sustainability; Publications; Radiation therapy; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resolution; Resources; Rodent; Sampling; Series; Services; Signal Pathway; Students; System; Technology; Time; Training; Training Support; Translational Research; Tumor Biology; Universities; West Virginia; X-Ray Computed Tomography; Xenograft Model; animal imaging; cancer care; clinically relevant; design; efficacy testing; experience; extracellular; health disparity; human model; imaging facilities; imaging study; imaging system; improved; in vivo; instrumentation; member; microCT; molecular imaging; mouse model; new technology; non-invasive imaging; novel; novel therapeutics; operation; patient derived xenograft model; pre-clinical; pre-clinical research; programs; recruit; single cell analysis; success; therapeutic target; tool; treatment response; tumor; tumor growth; tumor microenvironment; tumor progression; tumorigenesis

PROJECT SUMMARY/ABSTRACT The Animal Models & Imaging Facility (AMIF) provides state-of-the-art, preclinical molecular imaging services for biomedical research at West Virginia University. Animal models of disease are a critical tool for the translational research projects that promote understanding of the factors that influence the progression of disease and the impact of potential therapeutic targets. Cancer researchers, in particular, need to be able to study tumor growth and metastasis in the context of the microenvironment in real time and in living animals to determine the events that initiate tumorigenesis, promote cancer progression or impact response to treatment. As part of the Tumor Microenvironment Center of Biomedical Research Excellence (TME CoBRE), the AMIF has expanded its imaging and preclinical treatment capabilities with the addition of new equipment for radiation therapy, electron paramagnetic resonance and magnetic resonance imaging, and for high-resolution micro computed tomography. The AMIF is the only facility on campus that can offer these longitudinal, non-invasive imaging studies with sufficient resolution for working in small animal models. The long-term goals of this core are to (1) establish novel treatment and imaging resources in an existing core facility to support translational research projects targeting the tumor microenvironment and (2) provide training and support for investigators using preclinical models to study cancer biology. This TME CoBRE-supported core will synergize with other Institutional Development Award (IDeA)-funded projects including other CoBRE projects, the IDeA Network of Biomedical Research Excellence (INBRE), and the IDeA Clinical and Translational Research Award (IDeA-CTR) to enhance research competitiveness, improve therapy, and address health disparities, particularly in cancer. The AMIF provides opportunities for collaboration with other Centers at WVU resulting in the broadest impact of CoBRE investment. Further, it is integrated with the Patient-Derived Xenograft Core Facility in this TME CoBRE application through the study of mouse models using primary patient samples. In addition, it is highly connected to the Flow Cytometry Single Cell Analysis Core Facility that will provide downstream analysis of cells recovered from xenograft models. The AMIF is committed to mentoring and participates in the Technology Seminar Series in partnership with the other CoBRE Cores to enhance both education and collaboration across the CoBRE- supported initiatives.

项目摘要/摘要 动物模型与成像设施（AMIF）提供最先进的临床前分子成像服务 西弗吉尼亚大学的生物医学研究。动物模型是关键的工具 转化研究项目，以促进对影响影响进展的因素的理解 疾病和潜在治疗靶标的影响。尤其是癌症研究人员需要能够 在实时微环境和活体动物中研究肿瘤生长和转移 确定启动肿瘤发生，促进癌症进展或影响治疗反应的事件。 作为肿瘤微环境卓越生物医学研究中心（TME Cobre）的一部分，AMIF具有 通过增加辐射设备来扩展其成像和临床前处理能力 治疗，电子顺磁共振和磁共振成像，以及高分辨率微型 计算机断层扫描。 AMIF是校园中唯一可以提供这些纵向无创的设施 成像研究具有足够的分辨率，用于在小动物模型中工作。这个核心的长期目标 是（1）在现有的核心设施中建立新颖的治疗和成像资源以支持翻译 针对肿瘤微环境的研究项目，（2）为研究人员提供培训和支持 使用临床前模型研究癌症生物学。这个TME毛线支持的核心将与其他 机构发展奖（IDEA）资助的项目，包括其他毛to项目，构思网络 生物医学研究卓越（INBRE）以及IDEA临床和转化研究奖（IDEA-CTR） 为了增强研究竞争力，改善治疗并解决健康差异，尤其是在癌症中。 AMIF为与WVU的其他中心合作提供了机会，从而产生了最广泛的影响 田园投资。此外，它与此TME Cobre中的患者衍生的异种移植核心设施集成 通过研究小鼠模型使用主要患者样品的应用。另外，它是高度连接的 对于流式细胞仪单细胞分析核心设施，该设施将提供恢复的细胞的下游分析 来自异种移植模型。 AMIF致力于指导并参加技术研讨会系列 与其他山核桃核心合作，以增强整个鞋底的教育和协作 支持的举措。