TRAINING AND RESEARCH ON SEVERE MALARIAL ANEMIA

严重疟疾贫血的培训和研究

• 批准号: 6952189
• 负责人: Douglas Jay Perkins
• 金额: $ 1.44万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-22 至 2006-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6952189
• 关键词: Africa; anemia; genetics; hematology; immunology; international cooperation; malaria; public health; statistics /biometry; training

In this application, we propose to establish the University of Pittsburgh International Malaria Training and Research Program (IMTRP) by forging a strong alliance with Kenyatta University in Nairobi, Kenya, to study severe malaria anemia (SMA) in children. The objective of this program is to train local scientists that operate independently within Kenya to face the overwhelming morbidity and mortality placed on the Kenya people by SMA. The superb training and enabling environment at the University of Pittsburgh in the Graduate School of Public Health and Kenyatta University at the Centre for Complementary Medicine and Biotechnology (CCMB), respectively, including our strong collaborative ties with key institutions and researchers in Kenya, will facilitate the accomplishment of this goal. Over the course of this 4 year training program, we propose to train one postdoctoral fellow and two doctoral students at the University of Pittsburgh. The field-research will take place in Kisuma, Kenya, a holoendemic area of malaria transmission in western Kenya. In this area, the primary presentation of complicated malaria is severe malarial anemia with the highest frequency predominating in children under two years of age. In addition, a re-entry grant will be incorporated into the program to enable Kenyan scientist(s) to set-up/upgrade laboratory infrastructure at the CCMB and contribute to research activities therein. In years 1 and 3 of the project, we shall hold a three-week short-term intensive training course on infectious disease control including Immunology, Genetics, Hermatology, Epidemiology, and Biostatistics. The course will be held at Kenyatta University and will be taught by researchers from Kenya and the US. The overall project we have assembled, will ensure that all participants in the University of Pittsburgh IMTRP program receive strong didactic training focusing on the most important themes requisite in the understanding of the pathogenesis and effective control and management of SMA.

在此应用程序中，我们建议通过与肯尼亚内罗毕的肯雅塔大学建立牢固的联盟来建立匹兹堡大学国际疟疾培训与研究计划（IMTRP），以研究儿童严重的疟疾贫血（SMA）。该计划的目的是培训在肯尼亚在肯尼亚独立运作的当地科学家，面对SMA对肯尼亚人民的压倒性发病率和死亡率。匹兹堡大学公共卫生学院和肯雅塔大学互补医学与生物技术中心（CCMB）的精湛培训和支持环境，包括我们与肯尼亚的主要机构和研究人员的牢固合作关系，将促进该目标的成就。在这项为期4年的培训计划中，我们建议在匹兹堡大学培训一名博士后研究员和两名博士生。该实地研究将在肯尼亚的肯尼亚基苏马举行，这是肯尼亚西部疟疾传播的全部地区。在这一地区，复杂疟疾的主要表现是严重的疟疾贫血，两岁以下儿童的频率最高。此外，该计划将重新进入赠款，以使肯尼亚科学家能够在CCMB设置/升级实验室基础设施，并为其中的研究活动做出贡献。在该项目的第1和第3年，我们将举办三周的有关传染病控制的短期强化培训课程，包括免疫学，遗传学，雌雄同体学，流行病学和生物统计学。该课程将在肯雅塔大学举行，并将由肯尼亚和美国的研究人员教授。我们组装的整体项目将确保匹兹堡大学IMTRP计划的所有参与者都接受强大的教学培训，重点是理解SMA发病机理以及有效控制和管理SMA所需的最重要主题。