Duke University Molecular Imaging Center

杜克大学分子成像中心

• 批准号: 6847137
• 负责人: George ALLAN JOHNSON
• 金额: $ 60.22万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-30 至 2006-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6847137
• 关键词: Adenoviridae; Animalia; X ray microscopy; bioimaging /biomedical imaging; combination cancer therapy; diagnosis design /evaluation; gene therapy; genetic promoter element; heat shock proteins; interleukin 12; liposomes; luciferin monooxygenase; molecular /cellular imaging; neoplasm /cancer; neoplasm /cancer chemotherapy; neoplasm /cancer diagnosis; neoplasm /cancer radiation therapy; neoplasm /cancer thermotherapy; nonhuman therapy evaluation; nuclear magnetic resonance spectroscopy; reporter genes; single photon emission computed tomography; transfection /expression vector

DESCRIPTION (provided by applicant): We propose the formation of the Duke University Molecular Imaging Center (DUMIC) consisting of a consortium of cancer researchers and imaging scientists. The goals of the program are to a) develop the integrated technologies required for multi-modality molecular imaging in small animals, b) apply these technologies to important basic questions in cancer research, c) effectively disseminate the technologies, and d) train the next generation of technologists and scientists in the use of these technologies. More specifically, we will provide an infrastructure to allow cancer researchers at Duke to exploit and integrate the following imaging resources: l) In viva magnetic resonance microscopy to 50 x 50 x 50 microns (1.25 x 10-4 mm3) and magnetic resonance histology to 10 x 10 x 10 microns (1 x 10-6 mm3), 2) X-ray microscopy to 20 x 20 microns @ 10 ms temporal resolution, 3) Optical imaging for detection of luciferase reporter gene expression in vivo with sensitivity down to 1000 cells and spatial resolution down to 50 microns, 4) microSPECT to spatial resolution of less than or equal to 1 x 1 x 1 millimeters, 5) microPET to spatial resolution of less than or equal to 2 x 2 x 2 millimeters, 6) State-of-the-art animal support with real-time physiologic monitoring, 7) A unified image analysis environment to facilitate integration of imaging studies.

描述（由申请人提供）：我们提议组建公爵 大学分子成像中心 (DUMIC) 由以下联盟组成 癌症研究人员和成像科学家。该计划的目标是 a) 开发多模态分子所需的集成技术 小动物成像，b）将这些技术应用于重要的基础 癌症研究中的问题，c) 有效传播技术，以及 d) 培训下一代技术人员和科学家使用 这些技术。更具体地说，我们将提供基础设施 允许杜克大学的癌症研究人员利用和整合以下内容 成像资源：l) 体内磁共振显微镜，分辨率为 50 x 50 x 50 微米 (1.25 x 10-4 mm3) 和磁共振组织学可达 10 x 10 x 10 微米 (1 x 10-6 mm3), 2) X 射线显微镜可达 20 x 20 微米 @ 10 ms 时间分辨率，3) 用于检测荧光素酶报告基因的光学成像 体内基因表达，灵敏度低至 1000 个细胞和空间 分辨率低至 50 微米，4) microSPECT 空间分辨率更低 大于或等于 1 x 1 x 1 毫米，5) microPET 的空间分辨率为 小于或等于 2 x 2 x 2 毫米，6) 最先进的动物 支持实时生理监测，7）统一的图像分析 环境，以促进成像研究的整合。