HYPERPOLARIZED GAS IMAGING AT THE DIFFUSION LIMIT

扩散极限下的超极化气体成像

• 批准号: 8363164
• 负责人: George ALLAN JOHNSON
• 金额: $ 1.23万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363164
• 关键词: Coupled; Diffusion; Funding; Gases; Grant; Image; Lung; Microscopy; Mus; National Center for Research Resources; Predisposition; Principal Investigator; Radial; Research; Research Infrastructure; Resolution; Resources; Source; Technology; United States National Institutes of Health; cost; improved; in vivo

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We will develop multi-channel (1H/3He and 129Xe/1H) 3D radial encoding for in vivo imaging of the mouse lung at the spatial resolution posed by diffusion and susceptibility limits. To achieve this aim, we will integrate three tightly coupled improvements in technology: -- We will integrate a dual-channel rf coil into our imaging chain for simultaneous acquisition at 85 and 64 MHz to improve the sensitivity. -- We will install new higher strength gradients (400 mT/m) to reduce the impact of diffusion. -- We will optimize a 3D (dual-channel) radial acquisition sequence to limit the effects of susceptibility.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 我们将开发多通道（1H/3HE和129XE/1H）3D径向编码，以在通过扩散和易感限制构成的空间分辨率下进行小鼠肺的体内成像。 为了实现这一目标，我们将整合三个紧密耦合的技术改进： - 我们将将双通道RF线圈集成到我们的成像链中，以在85和64 MHz的同时获得以提高灵敏度。 - 我们将安装新的高强度梯度（400 mt/m），以减少扩散的影响。 - 我们将优化3D（双通道）径向采集序列，以限制易感性的影响。