Agilent Direct Drive 9.4T MRS/MRI Console

安捷伦直接驱动 9.4T MRS/MRI 控制台

• 批准号: 8247218
• 负责人: George ALLAN JOHNSON
• 金额: $ 59.67万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-15 至 2013-11-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8247218
• 关键词: 12 year old; Coupled; Diffusion; Diffusion Magnetic Resonance Imaging; Funding; Generations; Grant; Image; Magnetic Resonance; Magnetic Resonance Imaging; Microscopy; Research Personnel; Resolution; Resources; Scanning; Scientist; System; Time; United States National Institutes of Health; Work; cryogenics; novel

DESCRIPTION (provided by applicant): We propose the replacement of a 12-year-old GE (Signa LX) MRI console with a state-of-the-art Varian/Agilent console to support magnetic resonance microscopy for scientists throughout the world. Coupled to an existing 9.4T magnet and a new generation of cryogenic rf probe, this truly unique imaging system will support spatial resolution at the diffusion limit (<10 micrometers). A novel diffusion tensor imaging strategy will provide routine imaging with isotropic spatial resolution <20 micrometers. This resource will support the work of 18 NIH-funded investigators with 27 NIH grants. The system will allow us to increase the throughput for routine magnetic resonance microscopy by more than 3 times; increase the spatial resolution over limited fields by nearly 10 times; and reduce the scan time for diffusion tensor microscopy by at least 4 times. PUBLIC HEALTH RELEVANCE: Sequencing of the human genome has opened an entirely new era of molecular medicine, and one of the most critical issues faced is connecting the vast information in the sequenced human genome to the physical expression-the phenotype. Mouse models are one a critical vehicles to this understanding. Magnetic resonance histology will be used to understand changes in brain morphology of a number of the most critical models, helping connect genotype to phenotype.

描述（由申请人提供）： 我们建议用最先进的Varian/Agilent控制台替换12岁的GE（Signa LX）MRI控制台，以支持全世界科学家的磁共振显微镜。这种真正独特的成像系统结合到现有的9.4T磁铁和新一代的低温RF探针，将在扩散极限（<10微米）下支持空间分辨率。一种新型的扩散张量成像策略将以各向同性空间分辨率<20微米提供常规成像。该资源将支持18名NIH资助的调查员的工作，并提供27名NIH赠款。该系统将使我们能够将常规磁共振显微镜的吞吐量增加超过3倍。将有限场上的空间分辨率增加近10倍；并将扩散张量显微镜的扫描时间减少至少4次。 公共卫生相关性：人类基因组的测序开辟了一个全新的分子医学时代，最关键的问题之一是将测序的人类基因组中的庞大信息与物理表达 - 表型联系起来。鼠标模型是这种理解的关键工具。磁共振组织学将用于了解许多最关键模型的脑形态变化，有助于将基因型与表型联系起来。

项目成果

Magnetic resonance histology.

磁共振组织学。

• DOI: 10.1002/jmri.24774
• 发表时间: 2015
• 期刊: Journal of magnetic resonance imaging : JMRI
• 作者: Johnson,GAllan

Mouse model of rare TOR1A variant found in sporadic focal dystonia impairs domains affected in DYT1 dystonia patients and animal models.

• DOI: 10.1016/j.nbd.2016.05.003
• 发表时间: 2016-09
• 期刊: Neurobiology of disease
• 影响因子: 6.1
• 作者: Bhagat SL;Qiu S;Caffall ZF;Wan Y;Pan Y;Rodriguiz RM;Wetsel WC;Badea A;Hochgeschwender U;Calakos N
• 通讯作者: Calakos N

A time-course study of actively stained mouse brains: Diffusion tensor imaging parameters and connectomic stability over 1 year.

• DOI: 10.1002/nbm.4611
• 发表时间: 2022-01
• 期刊: NMR in biomedicine
• 影响因子: 2.9
• 作者: Xiao J;Hornburg KJ;Cofer G;Cook JJ;Pratson F;Qi Y;Johnson GA
• 通讯作者: Johnson GA

Automated segmentation of the canine corpus callosum for the measurement of diffusion tensor imaging.

用于测量弥散张量成像的犬胼胝体自动分割。

• DOI: 10.1177/1971400915610924
• 发表时间: 2016
• 期刊: The neuroradiology journal
• 作者: Peterson,DavidE;Chen,StevenD;Calabrese,Evan;White,LeonardE;Provenzale,JamesM
• 通讯作者: Provenzale,JamesM

Susceptibility tensor imaging and tractography of collagen fibrils in the articular cartilage.

• DOI: 10.1002/mrm.26882
• 发表时间: 2017-11
• 期刊: Magnetic resonance in medicine
• 影响因子: 3.3
• 作者: Wei H;Gibbs E;Zhao P;Wang N;Cofer GP;Zhang Y;Johnson GA;Liu C
• 通讯作者: Liu C