PhysioTelemeter for Autonomic Monitoring

用于自主监测的 PhysioTelemeter

• 批准号: 6963693
• 负责人: DAVID J EDELL
• 金额: $ 14.88万
• 依托单位: INNERSEA TECHNOLOGY, INC
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6963693
• 关键词: autonomic disorder; autonomic nervous system; biomedical device power system; biomedical equipment development; biosensor device; clinical research; diabetes mellitus; diabetic neuropathy; human subject; neuropathology; neurophysiology; patient monitoring device; spinal cord injury; telemetry

DESCRIPTION (provided by applicant): A "PhysioTelemeter(tm)" system for physiological research and clinical monitoring of autonomic nervous system function in Spinal Cord Injury (SCI) and Diabetes is proposed. The system will allow non-invasive, unobtrusive, wireless monitoring of multiple physiological variables at multiple locations where long term use or freedom of movement is desirable. The Phase-1 system will consist of 3 battery powered PhysioTelemeters(tm), each transmitting on a unique radio frequency to a remote receiver and a computer for display and archive. Each telemeter will transmit data from 4 exemplary sensors (bioelectric, temperature, vibration and battery voltage) up to 10M in distance. The Phase-1 telemeters will be approximately the diameter and weight of a US quarter, but twice as thick, and will operate for over 8 hours from a lithium coin cell battery. This small size and light weight will allow measurements in active subjects with the PhysioTelemeters(tm) temporarily adhered to the skin over the regions of interest. Clinical collaborators for Phase-1 include a Physical Medicine and Rehabilitation clinician with expertise in SCI pathophysiology, and a physiologist with clinical expertise in dysautonomia in patients with diabetes. These collaborators will review and critique the technology at various stages to guide the technology, and will evaluate the system with limited human testing on healthy subjects in preparation for Phase-2, During Phase-2, clinical collaborators will utilize the Phase-1 prototype system extensively to determine the practical utility of the approach in their clinical practice and research. Two active measurements (skin perfusion and impedance) will be added. The system will be further optimized including use of custom integrated circuits to decrease size and power, increasing the range to 30M, adding 5 more frequency channels for a total of 8, developing an environmentally resistant package, and providing a rechargeable battery system.

描述（由申请人提供）：提出了一种“物理 - eLemeter（TM）”系统，用于脊髓损伤（SCI）和糖尿病的自主神经系统功能的生理研究和临床监测。该系统将允许在多个位置对多个生理变量进行无创，不引人注目的无线监控，这些位置是长期使用或运动自由的多个位置。 相1系统系统将由3个电池供电的物理电子仪（TM）组成，每个物理仪（TM）都以唯一的射频传输到远程接收器，以及用于显示和存档的计算机。 每个遥测表将从4个示例传感器（生物电，温度，振动和电池电压）中传输数据，距离为10m。 1阶段遥测器的直径和重量大约是美国季度的直径和重量，但厚度是厚度的两倍，并且将从锂硬币电池电池中运行8个小时以上。这种小的尺寸和轻质的重量将允许在感兴趣区域暂时粘附在皮肤上的物理毛细管（TM）的活动受试者中进行测量。 第1阶段的临床合作者包括具有SCI病理生理学专业知识的物理医学和康复临床医生，以及具有糖尿病患者功能障碍的临床专业知识的生理学家。这些合作者将在各个阶段审查和批评这项技术，以指导技术，并通过对健康受试者进行有限的人体测试来评估该系统，以准备第2阶段， 在第2阶段，临床合作者将广泛利用第1阶段原型系统来确定该方法在其临床实践和研究中的实用性。将增加两项主动测量（皮肤灌注和阻抗）。该系统将进一步优化，包括使用自定义集成电路来降低尺寸和功率，将范围增加到30m，增加5个频道，总计8个，开发了一个抵抗环境的包装，并提供了可充电的电池系统。