'INTRA-CORTICAL NEURO RECORDING TELEMETER'

“皮质内神经记录遥测仪”

• 批准号: 6188641
• 负责人: DAVID J EDELL
• 金额: $ 29.33万
• 依托单位: INNERSEA TECHNOLOGY, INC
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-15 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6188641
• 关键词: Macaca mulatta; bioengineering /biomedical engineering; brain electrical activity; cats; dogs; electrodes; electronic recording system; implant; laboratory rabbit; medical implant science; microelectrodes; neuroanatomy; neurophysiology; pia mater; technology /technique development; telemetry

A new technology will be developed for long term neural recordings using intra-cortical microelectrode arrays. One important desired feature of long-term neural recordings is the ability to record from the same neurons from month to month or year to year. However, with existing technology this is very difficult to accomplish. One possible reason may be motion of the microelectrode array relative to the neural tissue caused by wiring from the arrays to the skull. A small, lightweight, wireless neural recording telemeter embedded in the pia so it could move with the brain may exhibit improved capacity for reproducibly recording from single units for long times. The objective of the proposed work is to develop and evaluate a tetherless, small, lightweight 16-channel telemeter. This telemeter will be attached directly to intra-cortical microelectrode arrays for placement on the pia. The packaging will be of the appropriate materials and shape to encourage encapsulation and stabilization by the pia. Data and power will be telemetered through the skull to external instrumentation. Rabbit, dog, cat and monkey will be used as animal models in this study to evaluate the technology in a variety of circumstances and with a variety of existing protocols. Metrics of the technology include: long term assessment of the electrical properties of the system; length of time that single units can be maintained; amplitude stability of single units over time; neuron density about the microelectrodes; degree of encapsulation by the pia; migration distance of the microelectrodes; and evidence of micro-hemorrhages. The primary application of this technology will be to facilitate long term intra-cortical chronic recordings for neuroscience. Perhaps when the technology is fully developed, it will be possible to apply it to rehabilitation of the spinal cord injured. An example would be for extraction of motor control information for control of functional electrical stimulation systems.

使用皮质内微电极阵列将开发一项新技术，用于长期神经记录。 长期神经记录的一个重要期望特征是能够从每月或每年从同一神经元记录。 但是，使用现有技术，这很难实现。 一个可能的原因可能是微电极阵列的运动相对于从阵列到头骨的接线引起的神经组织。 PIA中嵌入的小型，轻巧的无线神经记录遥测遥测器可以随着大脑而移动，可以长期从单个单元中复制记录的能力。拟议的工作的目的是开发和评估无绳，轻巧的16频道遥测仪。 该遥测表将直接连接到皮层内微电极阵列，以放置在PIA上。 包装将是适当的材料和形状，以鼓励PIA封装和稳定。 数据和功率将通过头骨遥控到外部仪器。在本研究中，兔子，狗，猫和猴子将用作动物模型，以在各种情况下以及各种现有协议中评估技术。 该技术的指标包括：对系统的电气性能的长期评估；可以维持单个单元的时间长度；随着时间的推移，单个单元的振幅稳定性；微电极周围的神经元密度； PIA的封装程度；微电极的迁移距离；和微毛病的证据。该技术的主要应用将是促进神经科学的长期皮质内慢性记录。也许当技术完全开发时，就可以将其应用于脊髓受伤的康复。 一个例子是提取电动机控制信息，以控制功能电刺激系统。