DEVELOPMENT OF AN IMPLANTABLE EMG MICRO-TELEMETER

植入式肌电微遥测仪的开发

• 批准号: 6015742
• 负责人: DAVID J EDELL
• 金额: $ 11.95万
• 依托单位: INNERSEA TECHNOLOGY, INC
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-15 至 2001-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6015742
• 关键词: biomedical equipment development; clinical biomedical equipment; connective tissue; electromyography; implant; laboratory rabbit; microelectrodes; miniature biomedical equipment; optics; telemetry

The objective is to establish a new telemeter for reliable ElectroMyoGram (EMG) transcription that will provide higher quality prosthesis control signals. EMGs are electrical potential recordings that proportionally reflect the contractile force of a muscle. EMGs from residual muscles in an amputee's stump are used to control electrically powered prosthetic systems. For amputees, EMGs are currently sensed using skin surface electrodes. These skin surface electrodes have practical limitations that significantly affect control performance. The proposed EMG telemeters will consist of bipolar electrodes that contact the surface of the target muscle and custom integrated circuits to amplify, encode and transmit the EMG signal. They will exhibit: 1) freedom from electromagnetic interference; 2) immunity from crosstalk with adjacent muscles; 3) freedom from skin motion and conductivity interference; 4) improved signal to noise amplitudes; and 5) improved long-term signal reproducibility. Assemblies will be encapsulated, tested in saline solution and implanted on the surface of muscles in animals. Performance will be evaluated using simultaneous recordings from skin electrodes, the telemeters, and from wired connections to the electrodes on the surface of the muscle. Recording fidelity will be compared over time. Tissue surrounding the implanted devices will be histologically evaluated for biocompatibility and device fixation. PROPOSED COMMERCIAL APPLICATIONS: EMG telemeters could be retrofitted to all existing myoelectric control systems and thus would have an immediate market of about 100,000 US citizens. Other applications include telemetry of data on demand for all implantable biosensor systems. A small market for physiology applications may also exist.

目标是建立一种新的遥测仪，用于可靠的肌电图 (EMG) 转录，从而提供更高质量的假肢控制信号。肌电图是按比例反映肌肉收缩力的电位记录。来自截肢者残肢残余肌肉的肌电图用于控制电动假肢系统。对于截肢者，目前使用皮肤表面电极来感测肌电图。这些皮肤表面电极具有显着影响控制性能的实际局限性。拟议的肌电图遥测仪将由接触目标肌肉表面的双极电极和定制集成电路组成，以放大、编码和传输肌电图信号。他们将展示：1）不受电磁干扰； 2）免受与相邻肌肉串扰的影响； 3）不受皮肤运动和电导率干扰； 4）改善信噪比幅度； 5) 改善长期信号再现性。组件将被封装，在盐水溶液中进行测试，并植入动物的肌肉表面。将使用皮肤电极、遥测仪以及肌肉表面电极的有线连接的同步记录来评估性能。将随时间比较录音保真度。将对植入设备周围的组织进行组织学评估，以评估其生物相容性和设备固定情况。拟议的商业应用：EMG 遥测仪可以改装到所有现有的肌电控制系统上，因此将立即拥有约 100,000 名美国公民的市场。其他应用包括所有可植入生物传感器系统的按需数据遥测。生理学应用也可能存在一个小市场。