Dielectric Characterization of Human Breast Tissue

人类乳腺组织的介电特性

• 批准号: 6621845
• 负责人: SUSAN C HAGNESS
• 金额: $ 17.92万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-05 至 2005-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6621845
• 关键词: biomedical equipment development; biophysics; biopsy; breast neoplasm /cancer diagnosis; breast neoplasms; clinical research; computer data analysis; diagnostic tests; dielectric property; early diagnosis; electrical measurement; female; human data; human tissue; mammary gland; method development; microwave radiation; neoplasm /cancer classification /staging; statistics /biometry; women's health

The objective of the proposed research is to conduct a comprehensive set of measurements to determine the dielectric properties of malignant, benign, and normal breast tissues over a broad frequency range from 100 MHz to 20 GHz. The outcome of the proposed research will be the baseline data needed to test two hypotheses: a) there exists a systematic and significant contrast in the dielectric properties of normal breast tissue and malignant breast lesions at microwave frequencies, and b) there exists a systematic and significant contrast in the dielectric properties of benign breast lesions and malignant breast lesions at microwave frequencies. The data resulting from these measurements are needed to facilitate the engineering of non- invasive, non-ionizing microwave technology to complement and augment early detection, diagnostic, and treatment technologies presently employed in the detection and management of breast cancer. The long-term objective of our research is to improve breast cancer screening through the use of space-time microwave imaging as a complement to X-ray mammography. The data obtained from the proposed study will permit subsequent development of a practical microwave breast imaging system for clinical trials. The specific aims are: 1) To rigorously calibrate and test coaxial needle probes that will be used with a microwave vector network analyzer to obtain the dielectric permittivities and conductivities of freshly excised breast tissue samples for frequencies up to 20 GHz. 2) To measure at physiologic temperatures and moisture contents the dielectric properties of approximately 500 breast biopsy specimens and 60 breast reduction specimens. 3) To correlate the measured dielectric properties data with the complete surgical pathology reports for every breast biopsy and breast reduction specimen; the database will include fatty and fibroglandular normal breast tissue, benign tumors and proliferative lesions, and infiltrating and in situ carcinomas. 4) To conduct bio-electromagnetic dispersion analyses of the measured dielectric properties data and to assess the biophysical mechanisms for the observed contrasts (or lack thereof). 5) To conduct statistical analyses of the measured data to test the two tissue-dielectric-contrast hypotheses. This research will provide a scientific foundation for all future microwave technology development related to the breast in the 0.1 to 20 GHz range, whether for tumor detection, monitoring, or treatment.

拟议研究的目的是进行一套全面的测量，以确定恶性、良性和正常乳腺组织在 100 MHz 至 20 GHz 的宽频率范围内的介电特性。 拟议研究的结果将是检验两个假设所需的基线数据：a）正常乳腺组织和恶性乳腺病变在微波频率下的介电特性存在系统且显着的对比，b）存在系统且显着的介电特性。微波频率下良性乳腺病变和恶性乳腺病变的介电特性存在显着差异。 需要从这些测量得到的数据来促进非侵入性、非电离微波技术的工程设计，以补充和增强目前用于乳腺癌检测和管理的早期检测、诊断和治疗技术。 我们研究的长期目标是通过使用时空微波成像作为 X 射线乳房 X 线摄影的补充来改善乳腺癌筛查。 从拟议研究中获得的数据将允许随后开发用于临床试验的实用微波乳腺成像系统。具体目标是： 1) 严格校准和测试同轴针式探头，该探头将与微波矢量网络分析仪一起使用，以获得频率高达 20 GHz 的新鲜切除的乳腺组织样本的介电常数和电导率。 2) 在生理温度和水分含量下测量约 500 个乳房活检标本和 60 个乳房缩小标本的介电特性。 3) 将测量的介电特性数据与每个乳房活检和乳房缩小标本的完整手术病理报告相关联；该数据库将包括脂肪和纤维腺体正常乳腺组织、良性肿瘤和增殖性病变、以及浸润性癌和原位癌。 4) 对测量的介电特性数据进行生物电磁色散分析，并评估观察到的对比（或缺乏对比）的生物物理机制。 5) 对测量数据进行统计分析，以检验两种组织介电对比假设。 这项研究将为未来所有与乳腺相关的 0.1 至 20 GHz 范围内的微波技术发展提供科学基础，无论是用于肿瘤检测、监测还是治疗。