3-D quantitative microwave breast imaging system for comparison with MRI

与 MRI 比较的 3D 定量微波乳腺成像系统

• 批准号: 8166091
• 负责人: SUSAN C HAGNESS
• 金额: $ 15.66万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-26 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166091
• 关键词: 3-Dimensional; Algorithms; Benchmarking; Breast; Breast Cancer Detection; Caring; Categories; Clinical; Clinical Engineering; Clinical Research; Collaborations; Comprehensive Cancer Center; Computational algorithm; Data; Data Set; Detection; Engineering; Environment; Evaluation; Frequencies; General Population; Goals; High Risk Woman; High-Risk Cancer; Human Subject Research; Image; Imaging Techniques; Imaging technology; Intervention; Laboratories; Magnetic Resonance Imaging; Mammary Gland Parenchyma; Mammography; Modality; Molecular; Monitor; Noise; Outcome; Patient Monitoring; Patients; Performance; Physiological; Population; Positioning Attribute; Prevention; Prevention Protocols; Property; Public Health Applications Research; Recording of previous events; Research; Research Personnel; Resolution; Risk; Risk Assessment; Risk Factors; Safety; Sampling; Scanning; Screening for cancer; Screening procedure; Sensitivity and Specificity; Signal Transduction; Solutions; System; Testing; Three-Dimensional Image; Time; Tissues; Treatment Protocols; Underserved Population; Universities; Validation; Wisconsin; Woman; Women' s Health; Work; base; breast density; cancer risk; clinical application; college; cost; density; design; dielectric property; experience; high risk; human subject; imaging modality; improved; innovation; malignant breast neoplasm; medical schools; meetings; microwave electromagnetic radiation; miniaturize; molecular imaging; prototype; research study; response; sensor; tool

DESCRIPTION (provided by applicant): There is a critical need to develop an affordable, non-ionizing, three-dimensional (3-D) quantitative imaging modality for screening women who are at higher risk for breast cancer and monitoring changes in breast tissue properties in response to treatment protocols. Given increasing recognition of the importance of breast density in individualized risk assessment and prevention decisions, there is also an emerging need to develop such a modality for evaluating breast density in the general population and monitoring changes in density in response to preventative interventions. 3-D microwave imaging - a non-ionizing molecular imaging technique that senses the endogenous (and possibly exogenously influenced) dielectric properties of breast tissue - has great potential to meet these needs. The long-term goal is to develop and integrate microwave imaging into the arsenal of tools available to the breast care clinician. The objective of this project, which is directed toward achieving this long-term goal, is to develop and evaluate a 3-D quantitative microwave imaging system based on advanced sensor hardware, algorithms, and computational platforms and to demonstrate the feasibility of performing a rigorous validation of microwave imaging against breast MRI, a clinical 3-D benchmark. The following specific aims will be pursued to achieve this objective: 1) Construct a compact, efficient 3-D microwave sensor system that enables co-registration with MRI; 2) Develop computationally efficient high- resolution 3-D microwave imaging algorithms that are integrated with the hardware system; and 3) Conduct a small-scale proof-of-concept imaging study with human research subjects. The project is innovative both in terms of the clinical applications and the technical approach. First, breast density evaluation and contrast- enhanced detection of breast cancer represent two new directions for microwave imaging. Second, our non- invasive quantitative microwave imaging system will employ efficient multi-band miniaturized antennas in a dense 3-D array and multi-frequency, physiologically constrained, 3-D inverse scattering algorithms. Most importantly, an innovative system configuration will maintain the position of the breast during both the MRI (benchmark) and microwave (test) scans, enabling an objective and unambiguous validation of microwave breast imaging. The proposed research is significant because it is expected to provide clinical evidence of the efficacy of 3-D microwave breast imaging and ultimately yield an affordable, widely available, and safe imaging solution for automated, quantitative breast density evaluation in the general population and cancer screening in a currently underserved sub-population of women who are known to be at higher risk. PUBLIC HEALTH RELEVANCE: The microwave imaging technology proposed here has demonstrated potential as an affordable, non-ionizing quantitative breast imaging modality that is sensitive to molecular changes in the breast. Important public health applications include breast cancer screening for high-risk patients, monitoring changes in breast tissue properties in response to prevention and treatment protocols, and evaluating breast density in the general population for risk assessment. The outcomes are expected to ultimately have a positive impact on the health of women worldwide, particularly those who are at greatest risk for breast cancer and who are in underserved populations.

描述（由申请人提供）：迫切需要开发一种经济实惠的非电离三维 (3-D) 定量成像方式，用于筛查乳腺癌风险较高的女性并监测乳腺组织特性的变化响应治疗方案。鉴于人们越来越认识到乳腺密度在个体化风险评估和预防决策中的重要性，也越来越需要开发这种模式来评估一般人群的乳腺密度并监测密度变化以响应预防性干预措施。 3D 微波成像是一种非电离分子成像技术，可感知乳腺组织的内源性（以及可能受外源性影响）介电特性，在满足这些需求方面具有巨大的潜力。长期目标是开发微波成像并将其集成到乳房护理临床医生可用的工具库中。该项目旨在实现这一长期目标，其目标是开发和评估基于先进传感器硬件、算法和计算平台的 3D 定量微波成像系统，并证明执行严格的微波成像与乳腺 MRI（临床 3D 基准）的验证。为了实现这一目标，我们将追求以下具体目标： 1）构建紧凑、高效的 3D 微波传感器系统，使其能够与 MRI 共同配准； 2）开发与硬件系统集成的计算高效的高分辨率3D微波成像算法； 3) 以人类研究对象为对象进行小规模概念验证成像研究。该项目无论在临床应用还是技术手段上均具有创新性。首先，乳腺密度评估和乳腺癌的对比增强检测代表了微波成像的两个新方向。其次，我们的非侵入式定量微波成像系统将采用密集 3D 阵列中的高效多频段小型化天线以及多频率、生理学约束的 3D 逆散射算法。最重要的是，创新的系统配置将在 MRI（基准）和微波（测试）扫描期间保持乳房的位置，从而实现微波乳腺成像的客观和明确的验证。拟议的研究意义重大，因为它有望提供 3D 微波乳腺成像功效的临床证据，并最终产生一种负担得起的、广泛使用且安全的成像解决方案，用于普通人群的自动定量乳腺密度评估和癌症筛查在目前服务不足的女性亚人群中，已知她们面临较高的风险。 公共健康相关性：本文提出的微波成像技术已证明具有作为一种经济实惠的非电离定量乳腺成像方式的潜力，该方式对乳房的分子变化敏感。重要的公共卫生应用包括对高风险患者进行乳腺癌筛查、监测乳腺组织特性的变化以响应预防和治疗方案，以及评估一般人群的乳腺密度以进行风险评估。预计研究结果最终将对全世界女性的健康产生积极影响，特别是那些乳腺癌风险最大和服务不足的人群。