Core--Mouse Biology and Stem Cell

核心--小鼠生物学与干细胞

• 批准号: 7054549
• 负责人: PETER M MAUCH
• 金额: $ 29.95万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7054549
• 关键词: animal colony; biomedical facility; drug screening /evaluation; genetic strain; laboratory mouse; radiation dosage; radiation protection; radiobiology; radioprotective agents

The purpose of the Mouse Biology and Stem Cell Core is to provide a wide range of murine-based assays for investigators from Project 1-3. Specific aims include (1) evaluation of normal mice and genetic (mutant) strains for LD50 (survival) after radiation, tissue pathology, hematopoietic cell culture, and chromose breakage (2) evaluation of IF profiles (signature profiles) (3) evaluation of biodosimetry in mice and (4) evaluation of candidate radioprotective agents in mice. Based on preclinical data in the mouse model, we will determine suitable radioprotective agents for further study.

小鼠生物学和干细胞核的目的是为项目1-3的研究人员提供广泛的基于鼠的测定。 Specific aims include (1) evaluation of normal mice and genetic (mutant) strains for LD50 (survival) after radiation, tissue pathology, hematopoietic cell culture, and chromose breakage (2) evaluation of IF profiles (signature profiles) (3) evaluation of biodosimetry in mice and (4) evaluation of candidate radioprotective 小鼠的特工。基于小鼠模型中的临床前数据，我们将确定合适的辐射保护剂以进行进一步研究。