CORE--PRIMATE

核心--灵长类

• 批准号: 6611188
• 负责人: JAMES W OVERSTREET
• 金额: $ 16.56万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-12 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6611188
• 关键词: Macaca; animal breeding; animal colony; biomedical facility; contraceptives; cooperative study; drug screening /evaluation; fertility immunology; fertilization; human tissue; nonhuman therapy evaluation; sperm

DESCRIPTION (provided by applicant): The objectives of this Core are to provide resources to the Center for studies of contraceptive targets in humans and non-human primates and for testing the effectiveness of contraceptive agents in primates. Specifically, the objectives of the Core are: 1. To provide the organizational structure and expertise required for application of concepts and products from basic research in Center Projects to human contraceptive development. 2. To provide a laboratory resource for biochemical and molecular biology studies to identify human and non-human primate homologs of contraceptive targets identified by Center Projects in the mouse model. 3. To provide an animal resource of non-human primates for preliminary testing of the safety of contraceptive agents and methods for their delivery. 4. To provide biological materials including tissues, body fluids and gametes from humans and non-human primates for in vitro assays of contraceptive actions. 5. To provide the facilities and expertise required for large-scale breeding studies with non-human primates to determine the efficacy and safety of contraceptive agents.

描述（由申请人提供）：该核心的目标是为 人类和非人类灵长类动物避孕靶标的研究中心以及测试灵长类动物中避孕药的有效性。具体而言，核心的目标是：1。提供从中心项目基础研究到人类避孕开发的概念和产品所需的组织结构和专业知识。 2。为生化和分子生物学研究提供实验室资源，以鉴定小鼠模型中心项目确定的避孕靶标的人类和非人类灵长类动物同源物。 3。提供非人类灵长类动物的动物资源，以初步测试避孕剂的安全性及其传递方法。 4。提供生物学材料，包括人类和非人类灵长类动物的组织，体液和配子，以进行避孕作用的体外测定。 5。提供非人类灵长类动物大规模育种研究所需的设施和专业知识，以确定避孕药的功效和安全性。