CORE--ANIMAL PROCEDURES

核心——动物程序

• 批准号: 7100664
• 负责人: Bernard E. Weissman
• 金额: $ 6.28万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7100664
• 关键词: animal colony; biomedical facility; carcinogen testing; chemical synthesis; disease /disorder model; drug screening /evaluation; laboratory mouse; neoplasm /cancer; reagent /indicator; veterinary science

The goal of the Animal Procedures Core Facility is to provide a central facility staffed by two skilled individuals to promote reproducible experimentation in laboratory animals. Services include drug screening, tumorigenicity testing and reagent production and small animal colony management. The Core is led by Dr. Bernard Weissman and Ms. Natalie Edmunds. The Core adds value to the Center by providing the animal tumor model expertise lacking in most laboratories, reducing the overall cost of such studies, ensuring a high level of reproducibility for animal studies and fostering interactions between Cancer Center members. Highlights of research supported by the Core include: highly-skilled maneuvers to characterize novel antineoplastic reagents including: intra-tibial inoculations, oral garage, and new treatments of NPC tumors with adenoviral reagents. Future plans for the Core include the addition of new Cancer Center users, expansion of colony management services including genotyping in conjunction with the Animal Models Core Facility and integration of small animal imaging with the new Small Animal Imaging Core Facility.

动物程序的目的核心设施是提供由两个熟练的人组成的中央设施，以促进实验动物的可重复实验。服务包括药物筛查，肿瘤性测试和试剂生产以及小动物菌落管理。核心由伯纳德·韦斯曼（Bernard Weissman）博士和娜塔莉·埃德蒙兹（Natalie Edmunds）女士领导。核心通过提供大多数实验室缺乏动物肿瘤模型的专业知识，从而降低了此类研究的整体成本，从而确保了动物研究的高度可重复性并促进癌症中心成员之间的相互作用，从而为中心增加了价值。核心支持的研究的亮点包括：高技能的动作以表征新型抗肿瘤 试剂包括：内临时接种，口腔车库和NPC肿瘤的新处理 腺病毒试剂。 核心的未来计划包括增加新的癌症中心用户，扩展菌落管理服务，包括与动物模型核心设施结合基因分型以及与新的小动物成像与新的小动物成像核心设施的整合。