Cancer Epigenetics Training Grant

癌症表观遗传学培训补助金

• 批准号: 10240322
• 负责人: Bernard E. Weissman
• 金额: $ 41.39万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10240322
• 关键词: Epigenetic Process; Grant; Malignant Neoplasms; Training

PROJECT SUMMARY This proposal seeks support for 6 postdoctoral fellows for a training program focused upon cancer epigenetics, a critical area of cancer research. Demand for training in this area has steadily increased, highlighting the crucial need for robust training programs. Surprisingly, no NCI-funded training program focused on this topic currently exists. UNC-Chapel Hill has recently emerged as a “hub” for epigenetics and cancer research, with over 35 faculty who actively perform epigenetics-focused research. Thus, we propose to create the first Cancer Epigenetics Training Program (CETP), leveraging our expertise in the area of chromatin and cancer biology with the resources of the University and the Lineberger Comprehensive Cancer Center (LCCC). This pool of preceptors will allow fellows to engage in interdisciplinary studies across the subspecialties of cancer epigenetics: Histone Biology, DNA Methylation, Chromatin Remodeling, RNA and Chemical Biology. The CETP program will be administered by a Director and Associate Director, with advice from a Training Oversight Committee and External and Internal Advisory Boards. Program evaluation will also include preceptor and trainee input via an annual, anonymous survey. Access to the LCCC’s core facilities, supported by the NCI Core Grant (rated “exceptional”), will further enhance the training environment. The LCCC will also provide significant support by funding of training events, yearly EAB visits, travel and lodging costs for interviews and for trainee travel to scientific meetings and salary support for program directors and staff. Fellows will jointly apply to the CETP and one or more mentor laboratories and undergo a rigorous selection process. Upon appointment, each fellow will develop a training plan approved by the preceptor, the Director, and Associate Director and establish a mentorship committee. During their first 2 years in the CETP, each fellow will participate in the following training events: (i) CETP colloquia that cover the breadth of epigenetics in the context of cancer development and treatment, (ii) a yearly CETP symposium to present current research projects, (iii) training in ethics in research (iv) a monthly research club, and (v) a grant writing and grant review program. Based on their individualized training plans, fellows may also participate in relevant training events sponsored by the LCCC. Progress will be monitored annually by the Director and Associate Director, along with the Training Oversight Committee, before renewal for Year 2 support. Although fellows are supported for two years, our trainees will be active in the CETP program and participate in multiple events throughout their tenure at UNC. The CETP will recruit trainees from underrepresented minorities through outreach to historically black and Hispanic universities and our yearly symposium on cancer epigenetics. The trainees who complete the CETP will be poised to become independent investigators focused upon this vital new area of cancer research.

项目摘要 该提案寻求支持6个博士后研究员，以针对癌症表观遗传学的培训计划， 癌症研究的关键领域。在这一领域对培训的需求悄然增加，突出了至关重要的 需要强大的培训计划。令人惊讶的是，目前没有NCI资助的培训计划针对此主题 存在。 UNC-Chapel Hill最近成为表观遗传学和癌症研究的“枢纽”，超过35 积极执行以表观遗传学为重点研究的教师。这，我们建议创建第一个癌症 表观遗传学培训计划（CETP），利用我们在染色质和癌症生物学领域的专业知识 大学和Lineberger综合癌症中心（LCCC）的资源。这个池 受体将使研究员能够在癌症的亚专业中进行跨学科研究 表观遗传学：组蛋白生物学，DNA甲基化，染色质重塑，RNA和化学生物学。 CETP 计划将由董事和副主任管理，并在培训监督的建议下进行 委员会以及外部和内部咨询委员会。计划评估还将包括主持人和 学员通过年度匿名调查输入。在NCI核心的支持下，访问LCCC的核心设施 格兰特（额定为“杰出”）将进一步增强培训环境。 LCCC还将提供重要的 通过资助培训活动，每年的EAB访问，旅行和住宿费用来支持面试和受训者 前往计划主管和员工的科学会议和薪水支持。 研究员将共同适用于CETP和一个或多个精神实验室，并进行严格的选择 过程。约会后，每个研究员将制定由主持人，董事，董事批准的培训计划 以及副主任并成立一个心态委员会。在他们在CETP的头两年中，每个人 将参加以下培训活动：（i）涵盖表观遗传学广度的CETP座谈会 癌症发展和治疗的背景，（ii）每年的CETP研讨会，以介绍当前的研究项目， （iii）研究伦理学培训（IV）每月研究俱乐部，以及（v）赠款写作和赠款审查计划。 根据他们的个性化培训计划，研究员还可以参加赞助的相关培训活动 由LCCC。董事兼副主任每年对进度进行监控，并进行培训 监督委员会，在续签2年级支持之前。尽管支持者得到了两年的支持，但我们的 学员将活跃于CETP计划，并在UNC任职期间参加多个活动。 CETP将通过向历史悠久的黑人和 西班牙裔大学和我们每年的癌症表观遗传学研讨会。完成CETP的学员 将被毒化成为独立研究人员，专注于这一至关重要的癌症研究领域。

项目成果

Cdyl Deficiency Brakes Neuronal Excitability and Nociception through Promoting Kcnb1 Transcription in Peripheral Sensory Neurons.

• DOI: 10.1002/advs.202104317
• 发表时间: 2022-04
• 期刊: Advanced science (Weinheim, Baden-Wurttemberg, Germany)
• 作者: Sun ZW;Waybright JM;Beldar S;Chen L;Foley CA;Norris-Drouin JL;Lyu TJ;Dong A;Min J;Wang YP;James LI;Wang Y
• 通讯作者: Wang Y

How to silence an X chromosome.

如何沉默 X 染色体。

• DOI: 10.1038/d41586-020-00207-0
• 发表时间: 2020
• 期刊: Nature
• 影响因子: 64.8
• 作者: Trotman,JacksonB;Calabrese,JMauro
• 通讯作者: Calabrese,JMauro