Core--Canine resource

核心--犬类资源

• 批准号: 7055187
• 负责人: BEVERLY J. TOROK-STORB
• 金额: $ 35.97万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7055187
• 关键词: animal care; animal tissue; biomedical facility; dogs; histocompatibility typing

The Canine Resource Core, will provide canids and canine tissue to all six research projects. This requires maintaining an adequate census for all approved studies, scheduling irradiations, scheduling all pre and post irradiation treatments, coordinating appropriate and timely sample acquisition and distribution, and maintaining a data base. Project-specific needs will also be met. These include tissue-typing for both Class I and II major histocompatibility complex (MHC) antigens for Projects 5 and 6; harvesting cord blood for Project 5, and obtaining skin biopsies for Project 1. To provide these services the CMCR Core will essentially add to the existing Large Animal Shared Facility of the FHCRC. This will necessitate some Alteration & Renovation (A&R) to provide additional housing to accommodate the increase in census, and to provide an additional treatment room to accommodate the increased number of procedures. It will also require adding additional staff. The increased number of dogs on study together with the new parameters to be analyzed also make it necessary to upgrade the canine database. All activities of the Core will be supervised by Dr Beverly Torok-Storb, who currently serves on the Large Animal Shared Facility User Committee. Without the services provided by the Core it would not be possible to study the number of dogs needed to identify the best intervention for a given radiation dose.

犬类资源核心将为所有六项研究提供犬类和犬类组织 项目。这需要对所有批准的研究进行充分的普查，安排 辐照，安排所有辐照前和辐照后治疗，协调适当和及时的 样本采集和分发，以及维护数据库。项目的特定需求也将得到满足。其中包括 I 类和 II 类主要组织相容性复合体 (MHC) 的组织分型 项目5和6的抗原；为项目 5 采集脐带血，并为项目 5 获取皮肤活检 项目 1. 为了提供这些服务，CMCR 核心将主要对 FHCRC 现有的大型动物共享设施进行补充。这将需要进行一些改造和翻新 (A&R)，以提供额外的住房以适应人口普查的增加，并提供额外的治疗室以适应增加的手术数量。它还需要增加额外的人员。研究犬只数量的增加以及需要分析的新参数也使得有必要升级犬只数据库。核心的所有活动将由 Beverly Torok-Storb 博士监督，她目前在大型动物共享设施用户委员会任职。如果没有核心提供的服务，就不可能研究确定给定辐射剂量的最佳干预措施所需的狗的数量。