Transnational Research Imaging Core (TRI)

跨国研究成像核心 (TRI)

基本信息

批准号：
10457963
负责人：
Dan TEODOR Simionescu
金额：
$ 33.26万
依托单位：
CLEMSON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10457963
关键词：
3-Dimensional Academic support Address Affect Animal Testing Animals Applications Grants Biocompatible Materials Biomedical Engineering Biomedical Research Cell Culture Techniques Cells Centers of Research Excellence Clinical Clinical Data Computer software Core Facility Data Degenerative Disorder Derivation procedure Development Digital Radiography Dimensions Disease Electrons Engineering Environment Evaluation Extramural Activities Family suidae Fees Financial Support Funding Generations Goals Goat Guidelines Histology Human Image Implant In Vitro Industry Institution Light Livestock Magnetic Resonance Imaging Maintenance Medicine Mentors Microscopy Mission Molecular Molecular Analysis Molecular Biology Natural regeneration Operating Rooms Operative Surgical Procedures Organ Outcome Phase Pilot Projects Population Postoperative Care Preclinical Testing Protocols documentation Public Health Regenerative Medicine Research Research Support Resources Safety Scientist Services Sheep South Carolina Stimulus Technology Testing Therapeutic Three-Dimensional Image Tissue Engineering Tissues Translational Research United States National Institutes of Health Universities Validation X-Ray Computed Tomography animal care animal facility animal imaging bioimaging biomaterial compatibility biomaterial development bioscaffold clinical imaging cost cytotoxicity cytotoxicity test digital digital imaging efficacy testing experience follow-up genotoxicity high standard image reconstruction imaging capabilities imaging facilities immunogenicity implantation improved in vitro testing in vivo in vivo evaluation innovation interest irritation microCT microscopic imaging novel pre-clinical preclinical safety programs reconstruction regenerative tissue repaired research clinical testing safety testing stem cell biology stem cells sustainable resource systemic toxicity technological innovation tissue regeneration tool ultrasound validation studies voucher

项目摘要

Regenerative medicine and tissue engineering are innovative therapeutic approaches that hold great promise in addressing unmet clinical needs. Application of these novel products and technologies in human medicine is limited by the complexities of pre-clinical safety and efficacy testing. By comparison to states with major NIH funding, a significant obstacle for academic scientists, engineers and industry experts involved with translational regenerative medicine efforts in the State of South Carolina is the lack of resources to sustain and evolve existing core facilities by keeping up with the rapid pace of new and costly technological innovations, compliance issues and regulatory protocols needed to advance new discoveries. This hinders the generation of preliminary data for competitive NIH proposals and limits our ability to pursue applied regenerative medicine efforts to benefit the population of South Carolina. To advance the goals of tissue engineering and regenerative medicine that were established in Phases I and II by our COBRE Center (SC BioCRAFT) we propose to upgrade and further develop our original Cell, Tissue and Molecular Analysis core into a more translationally oriented core entitled Translational Research Imaging (TRI) core. This Phase III core has been envisioned as the combination of a bio-analytical thrust for advanced microscopy and imaging and a pre-clinical validation thrust for small and large animal testing. The overall mission of the TRI core is to support academic scientists, engineers and biomedical industry experts in their pursuit of pre-clinical validation of novel biomaterials and technologies and enhance their potential for competitive extramural funding. To achieve this mission, we propose two specific aims: 1) to provide cutting- edge capabilities for stem cell biology, explant analysis, in vivo cell tracking, advanced histology, light and electron imaging and 3D image reconstruction capabilities and 2) to provide state-of-the-art facilities and expertise for pre-clinical validation of regenerative medicine approaches by offering small and large animal surgery and long-term testing and imaging capabilities including digital radiography, clinical CT and MRI. Outstanding facilities and labs directed by experienced NIH-funded scientists will provide a collaborative mentoring environment to all pilot projects PIs and to scientists and engineers interested in developing regenerative medicine projects. Management of core activities and sustainability beyond the Phase III period will be facilitated by our campus-wide core management software, by establishment of user fees and by using a voucher program. The proposed TRI core, together with the complementary Biomaterials Engineering and Testing core, both very strongly supported by Clemson University, will greatly enhance research capabilities and advance the potential for creation of a regenerative medicine powerhouse within the state of South Carolina.

再生医学和组织工程是创新的治疗方法，在以下领域具有广阔的前景：解决未满足的临床需求。这些新产品和技术在人类医学中的应用受到临床前安全性和有效性测试的复杂性的限制。与拥有主要 NIH 的州相比资金是参与转化的学术科学家、工程师和行业专家的一个重大障碍南卡罗来纳州的再生医学工作缺乏维持和发展现有资源的资源通过跟上新的和昂贵的技术创新的快速步伐、合规问题以及推进新发现所需的监管协议。这阻碍了初步数据的生成 NIH 的竞争性提案限制了我们追求应用再生医学努力以造福人类的能力南卡罗来纳州的人口。推进第一阶段和第二阶段制定的组织工程和再生医学目标通过我们的 COBRE 中心 (SC BioCRAFT)，我们建议升级和进一步开发我们原始的细胞、组织和分子分析核心转变为更加以转化为导向的核心，名为转化研究成像 (TRI) 核。该第三阶段核心被设想为先进的生物分析推动力的结合。显微镜和成像以及小型和大型动物测试的临床前验证推力。 TRI核心的总体使命是支持学术科学家、工程师和生物医学行业专家他们追求新型生物材料和技术的临床前验证，并增强其潜力有竞争力的外部资金。为了实现这一使命，我们提出两个具体目标：1）提供切割- 干细胞生物学、外植体分析、体内细胞追踪、先进组织学、光和电子成像和 3D 图像重建能力，2) 提供最先进的设施和通过提供小型和大型动物来进行再生医学方法临床前验证的专业知识手术以及长期测试和成像能力，包括数字放射线摄影、临床 CT 和 MRI。由经验丰富的 NIH 资助科学家领导的杰出设施和实验室将提供协作为所有试点项目 PI 以及对开发感兴趣的科学家和工程师提供指导环境再生医学项目。第三阶段之后的核心活动和可持续性管理将通过我们的校园核心管理软件、建立用户费用以及使用优惠券计划。拟议的 TRI 核心，以及互补的生物材料工程和测试核心均得到克莱姆森大学的大力支持，将极大地提高研究能力和提高在南卡罗来纳州创建再生医学强国的潜力。