Cell, Tissue, and Molecular Analysis

细胞、组织和分子分析

• 批准号: 8742733
• 负责人: Dan TEODOR Simionescu
• 金额: $ 35.51万
• 依托单位: CLEMSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8742733
• 关键词: Adult; Applications Grants; Area; Biochemistry; Bioinformatics; Biological Assay; Biomedical Engineering; Biomedical Research; Biophotonics; Cell Separation; Cells; Centers of Research Excellence; Collaborations; Core Facility; Data; Derivation procedure; Development; Electron Microscopy; Engineering; Environment; Equipment; Faculty; Fostering; Funding; Future; Gene Expression; Generations; Goals; Grant; Histology; Image; Institutes; Institution; Laboratories; Laboratory Personnel; Lead; Learning; Location; Mentors; Microscopy; Molecular; Molecular Analysis; Molecular Biology; Molecular Biology Techniques; Natural regeneration; Organelles; Outcome; Qualifying; Regenerative Medicine; Research; Research Infrastructure; Research Personnel; Research Support; Scientist; Services; Signal Transduction; Solutions; South Carolina; Stem Cell Research; Stem cells; Techniques; Tissue Engineering; Tissues; Transfection; United States National Institutes of Health; Universities; adult stem cell; beneficiary; cost; experience; in vivo; induced pluripotent stem cell; member; nanoparticle; programs; protein expression; ranpirnase; research facility; stem cell biology; tool

Project Summary: Cell, Tissue, and Molecular Analysis Core (CTMA core) Cell, tissue and molecular biology techniques are the cornerstone of biomedical research. A major hindrance for junior faculty in conducting this research is a lack of ultramodern facilities and specialized expertise commonly found in states with major NIH funding. To advance the regenerative medicine research potential within South Carolina, we have identified three thrust areas which will serve the needs of our SC BioCRAFT COBRE projects: 1) molecular biology, 2) stem cell biology, and 3) histology and advanced imaging. Outstanding facilities and labs directed by experienced investigators with expertise in these three thrust areas have been identified and brought together under the aegis of the Core to serve the needs of both COBRE PIs, and other investigators statewide. To achieve the goals of the COBRE center, our core proposes three specific aims: 1) to promote and facilitate advanced molecular biology research, 2) to enhance histology and advanced imaging infrastructure and expertise and 3) augment adult and induced stem cell research capabilities. The Core will be directed by experienced, NIH funded scientists with complementary expertise in regenerative medicine, gene and protein expression and manipulation, adult and induced stem cells, and advanced histology, electron microscopy and biophotonics. Fully functional and generously equipped facilities in Clemson, Greenville, Spartanburg, and Charleston SC will be joined to provide support for idea development, overcoming technical challenges and leading the target projects towards significant outcomes. The core has an impressive potential and provides all the necessary equipment and expertise to serve the SC investigators. Moreover, the core will foster a collaborative mentoring environment that will serve to introduce the newest techniques available in regenerative medicine research and greatly enhance the sustainability of our ongoing COBRE initiative.

项目摘要：细胞，组织和分子分析核心（CTMA核心） 细胞，组织和分子生物学技术是生物医学研究的基石。专业 初级教师进行这项研究的障碍缺乏超现代设施和专业 在拥有大量NIH资金的州通常发现的专业知识。推进再生医学研究 在南卡罗来纳州的潜力，我们已经确定了三个推力区域，这些区域将满足我们SC的需求 Biocraft Cobre项目：1）分子生物学，2）干细胞生物学和3）组织学和晚期 成像。 由经验丰富的调查员指导的杰出设施和实验室在这三个推力中具有专业知识 在核心的宙斯盾下，已经确定并聚集在一起，以满足两者的需求 PIS和其他调查人员全州。为了实现毛毛中心的目标，我们的核心提出了 三个具体目标：1）促进和促进晚期分子生物学研究，2）增强组织学 以及高级成像基础设施和专业知识以及3）增强成人和诱导干细胞研究 功能。核心将由经验丰富的，由NIH资助的科学家指导，具有互补的专业知识 再生医学，基因和蛋白质表达以及操纵，成人和诱导的干细胞，以及 晚期组织学，电子显微镜和生物素化学。 克莱姆森，格林维尔，斯巴达堡和查尔斯顿的功能齐全且设备齐全的设施 SC将加入，为思想发展提供支持，克服技术挑战并领导 针对重大结果的目标项目。核心具有令人印象深刻的潜力，并提供了所有 为SC调查人员提供服务的必要设备和专业知识。此外，核心将促进协作 指导环境将介绍再生医学中可用的最新技术 研究并大大提高了我们正在进行的索布雷倡议的可持续性。