Nutritional and Contractile Regulation of Muscle Growth

肌肉生长的营养和收缩调节

基本信息

批准号：
6945450
负责人：
Blake B Rasmussen
金额：
$ 30.92万
依托单位：
UNIVERSITY OF TEXAS MED BR GALVESTON
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-09-01 至 2008-08-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): The focus of this project is to examine physiological mechanisms that regulate human skeletal muscle growth. Muscle wasting is a common phenomenon in many conditions, such as cancer, AIDS, trauma, sepsis, kidney failure, and is also particularly prevalent in the elderly. The loss of muscle mass leads to overall weakness, immobility and physical dependence, and can be responsible for an impaired response to stress, which is associated with higher mortality rates during infection, surgery, and trauma. Nutrition and resistance exercise are two major protein anabolic stimuli for skeletal muscle. Our general hypothesis is that the magnitude of the protein anabolic response will be determined by the reciprocal interactions between these two stimuli. In particular, we propose that skeletal muscle protein accretion is dependent upon both the timing of the nutritional stimulus in relation to the exercise bout and the amount of energy provided by the nutritional stimulus. We further hypothesize that the muscle protein anabolic response following a nutrient stimulus or muscular contraction will be more pronounced in healthy young men than in young women. Specific aims: (1) To determine the magnitude of the acute response of skeletal muscle protein synthesis and net protein anabolism to a nutritional stimulus given before or after a bout of resistance exercise. (2) To determine the magnitude of the acute response of skeletal muscle protein synthesis and net protein anabolism to a nutritional stimulus providing an amount of energy that either matches or exceeds the exercise-induced energy expenditure. (3) To determine the differences between women and men in the response of skeletal muscle protein synthesis, efficiency of amino acid utilization for protein synthesis, leucine oxidation, and net protein anabolism to resistance exercise alone and in combination with a nutritional stimulus delivered before or after a bout of resistance exercise. Significance. These studies will provide insight into physiological mechanisms that regulate human muscle protein balance, and will be utilized as a basis from which to develop scientificallybased interventions for improving muscle protein balance in conditions such as aging, trauma, cancer, and AIDS.

描述（由申请人提供）：该项目的重点是检查调节人骨骼肌生长的生理机制。在许多情况下，肌肉浪费是一种常见现象，例如癌症，艾滋病，创伤，败血症，肾衰竭，在老年人中也尤其普遍。肌肉质量的丧失会导致总体弱点，不动和身体依赖，并可能导致对压力的反应受损，这与感染，手术和创伤期间的死亡率较高有关。营养和耐药性运动是骨骼肌的两个主要蛋白合成代谢刺激。我们的一般假设是，蛋白质合成代谢反应的大小将取决于这两个刺激之间的相互相互作用。特别是，我们建议骨骼肌蛋白积聚取决于营养刺激的时间与运动曲线有关，以及营养刺激提供的能量量。我们进一步假设，与年轻女性相比，健康的年轻男性在养分刺激或肌肉收缩后的肌肉蛋白合成代谢反应将更明显。具体目的：（1）确定骨骼肌蛋白合成的急性反应的大小和净蛋白合成物对耐药性运动之前或之后给出的营养刺激的净蛋白质合作。（2）确定骨骼肌蛋白合成和净蛋白合物对营养刺激的急性反应的大小，提供了与运动诱导的能量消耗相匹配或超过运动诱导的能量的能量。（3）确定男女在骨骼肌蛋白合成的反应中的差异，氨基酸利用蛋白质合成的效率，亮氨酸氧化以及单独或与营养刺激结合使用的抗抗性运动的净蛋白质合成物对耐药性运动一场抵抗运动之后。意义。这些研究将提供对调节人类肌肉平衡的生理机制的洞察力，并将被用作基于科学基于科学的干预措施，以改善衰老，创伤，癌症和艾滋病等条件下的肌肉蛋白质平衡。