Electrophysiological Assessment of ICC to A1 Projections

ICC 到 A1 投影的电生理评估

• 批准号: 6937680
• 负责人: Hubert Hyungil Lim
• 金额: $ 1.7万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6937680
• 关键词: acoustic nerve; auditory cortex; auditory discrimination; auditory nuclei; auditory pathways; auditory stimulus; auditory threshold; brain electrical activity; cell cell interaction; computer data analysis; ear /hearing prosthesis; electrical measurement; guinea pigs; inferior colliculus; microelectrodes; neural transmission; predoctoral investigator; sensorineural hearing loss; sound frequency; sound perception; speech recognition; time resolved data

DESCRIPTION (provided by applicant): This research is focused on assessing the inferior colliculus central nucleus (ICC) to primary auditory cortex (A1) neural projection using electrical stimulation (ES) of the ICC in a guinea pig model, in light of the development of a midbrain auditory prosthesis (MAP). Due to limitations of current auditory prostheses and the potential for improvements in frequency and level discrimination by ES of the ICC, experiments to determine the feasibility for a MAP are of interest. Therefore, it is important to study how the central auditory system organizes and processes sound information to assess how we might implement a MAP to achieve intelligible speech perception. A point-to-point tonotopic projection from the ICC to A1 has been shown. Thus, multi-channel electrodes will be used to electrically stimulate different ICC regions and simultaneously record neural activity across A1 to determine: (1) if segregated, parallel pathways from the ICC to A1 exist along the isofrequency dimension; and (2) if the temporal activation pattern along an isofrequency contour of A1 changes in response to ES of different regions within an isofrequency lamina of the ICC.

描述（由申请人提供）：这项研究的重点是评估使用ICC在豚鼠模型中使用ICC的电刺激（ES）的原代听觉皮层（A1）神经投射的下丘，鉴于中脑听觉疾病的发展（MAP）。由于当前的听觉假体的局限性以及ICC ES的频率和水平歧视的潜力，确定地图的可行性的实验引起了人们的关注。因此，重要的是要研究中央听觉系统如何组织和处理声音信息，以评估我们如何实施地图以实现可理解的语音感知。已经显示了从ICC到A1的点对点吨位投影。因此，多通道电极将用于电力刺激不同的ICC区域，并同时记录A1的神经活动，以确定：（1）如果隔离，从ICC到A1的平行途径沿等素程尺寸存在； （2）如果沿着A1的同源轮廓的时间激活模式会随着ICC的同频层中不同区域的响应而变化。