Electrophysiological Assessment of ICC to A1 Projections

ICC 到 A1 投影的电生理评估

• 批准号: 6885031
• 负责人: Hubert Hyungil Lim
• 金额: $ 3.27万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6885031
• 关键词: acoustic nerve; auditory cortex; auditory discrimination; auditory nuclei; auditory pathways; auditory stimulus; auditory threshold; brain electrical activity; cell cell interaction; computer data analysis; ear /hearing prosthesis; electrical measurement; guinea pigs; inferior colliculus; microelectrodes; neural transmission; predoctoral investigator; sensorineural hearing loss; sound frequency; sound perception; speech recognition; time resolved data

DESCRIPTION (provided by applicant): This research is focused on assessing the inferior colliculus central nucleus (ICC) to primary auditory cortex (A1) neural projection using electrical stimulation (ES) of the ICC in a guinea pig model, in light of the development of a midbrain auditory prosthesis (MAP). Due to limitations of current auditory prostheses and the potential for improvements in frequency and level discrimination by ES of the ICC, experiments to determine the feasibility for a MAP are of interest. Therefore, it is important to study how the central auditory system organizes and processes sound information to assess how we might implement a MAP to achieve intelligible speech perception. A point-to-point tonotopic projection from the ICC to A1 has been shown. Thus, multi-channel electrodes will be used to electrically stimulate different ICC regions and simultaneously record neural activity across A1 to determine: (1) if segregated, parallel pathways from the ICC to A1 exist along the isofrequency dimension; and (2) if the temporal activation pattern along an isofrequency contour of A1 changes in response to ES of different regions within an isofrequency lamina of the ICC.

描述（由申请人提供）：本研究的重点是在豚鼠模型中使用 ICC 的电刺激（ES）来评估下丘中央核（ICC）到初级听觉皮层（A1）的神经投射，根据发展中脑听觉假体（MAP）。由于当前听觉假体的局限性以及 ICC 的 ES 在频率和水平辨别方面的改进潜力，确定 MAP 可行性的实验引起了人们的兴趣。因此，研究中枢听觉系统如何组织和处理声音信息以评估我们如何实施 MAP 来实现可理解的语音感知非常重要。显示了从 ICC 到 A1 的点对点音调投影。因此，多通道电极将用于电刺激不同的 ICC 区域，并同时记录 A1 上的神经活动，以确定：（1）如果分离，则沿等频维度存在从 ICC 到 A1 的平行路径； (2) 沿着 A1 等频轮廓的时间激活模式是否响应 ICC 等频层内不同区域的 ES 而变化。