Animal and ABSL III

动物和ABSL III

• 批准号: 6857536
• 负责人: Clifford RICK LYONS
• 金额: $ 26.23万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6857536
• 关键词: animal colony; biomedical facility; bioterrorism /chemical warfare; disease /disorder model; laboratory mouse; respiratory infections

The analyses of animal models is complex and labor intensive. This Murine Animal Biosafety Level 3 Core (Core A) is designed to provide labor to all of the projects during experimental procedures that require an increased labor force. A smoothly operating ABSL 3 is critical to this program project and this core will be responsible for maintaining the ABSL and its equipment. The ABSL III facility in this program project is actually a combination lab capable of performing animal and cell culture experiments in it. While each of the projects has its own personnel to concentrate on the goals of that particular project, the maintenance, upkeep and labor intensity of the projects requires additional personnel that can assure that this core lab is maintained at a high level and assist with the labor intensive animal models and organ collection. There are many methods particularly related to the animal experiments that overlap among the different projects. Therefore having two experienced personnel that can enter into the animal experiments at critical times will be both cost effective and efficient as well as maintain quality control among the animal experiments. The role of Core A is: Aim 1. Maintain stocks and inoculation procedures to maintain reproducible models. Aim 2. Maintain compliance within the ABSL 3 lab for excellent biosafety and select agent status. Aim 3. Assist technicians assigned to projects in the labor intensive portion of animal experiments in Projects 1, 2 and 3.

动物模型的分析是复杂且劳动密集型的。该鼠科动物生物安全 3 级核心（核心 A）旨在为需要增加劳动力的实验过程中的所有项目提供劳动力。平稳运行的ABSL 3对该计划项目至关重要，该核心将负责维护ABSL及其设备。 该项目中的ABSL III设施实际上是一个能够进行动物和细胞培养实验的组合实验室。虽然每个项目都有自己的人员专注于该特定项目的目标，但项目的维护、保养和劳动强度需要额外的人员，以确保该核心实验室保持在高水平并协助劳动密集的动物模型和器官采集。有许多与动物实验特别相关的方法在不同项目之间重叠。因此，拥有两名经验丰富的人员可以在关键时刻进入动物实验将既具有成本效益又高效，并且可以维持动物实验的质量控制。核心 A 的作用是： 目标 1. 维护库存和接种程序以维持可重复的模型。目标 2. 保持 ABSL 3 实验室内的合规性，以实现出色的生物安全性并选择代理状态。目标 3. 协助分配到项目 1、2 和 3 动物实验劳动密集部分的技术人员。