Animal Core Facilities Addition/Renovation

动物核心设施增建/翻新

• 批准号: 6949839
• 负责人: SUSAN L SWAIN
• 金额: $ 342.99万
• 依托单位: TRUDEAU INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-19 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6949839
• 关键词: animal colony; biohazard control; biomedical facility; bioterrorism /chemical warfare; building /facility design /renovation; communicable diseases; flow cytometry; health science research; immunity; laboratory mouse; molecular biology

DESCRIPTION (provided by applicant): In response to PAR-04-122, Trudeau Institute submits a revised proposal to request matching funds to expand and improve its research core facilities. Trudeau Institute is a small, not-forprofit research institute focused on identifying mechanisms that regulate immunity to infectious disease, autoimmunity and cancer in young and aged individuals. The research aims of Trudeau investigators directly address the national goals of improving human health and increasing our ability to respond to emerging infectious diseases and bioterrorist threats. Trudeau Institute is part of a Regional Center of Excellence for Biodefense research and holds numerous PHS grants, totaling almost $7,000,000 in direct costs. Research at Trudeau Institute is dependent on state-of-the-art core facilities, including the Animal, Molecular Biology, Flow Cytometry and Animal Technical Services cores. However, these cores must be expanded and improved to meet the current and future research needs of the investigators. For example, the ABSL-2 and ABSL-3 facilities are 40 years old and require major updating and expansion. In addition, the Molecular Biology, Flow Cytometry and Animal Technical Services cores need to be consolidated and expanded. Therefore, we propose to construct a new building that will house mice requiring ABSL-2 (Aim 1), ABSL-3 (Aim 2) or quarantine level containment (Aim 3). The new building will also provide animal facility infrastructure and equipment needed to conduct infectious disease research (Aim 4). Finally, we propose to renovate the space currently used for housing infected animals in order to provide expanded, consolidated and contiguous space for the Molecular Biology, Flow Cytometry and the Animal Technical Services Cores (Aim 5).

描述（由申请人提供）： 为了回应 PAR-04-122，特鲁多研究所提交了一份修订提案，要求提供配套资金以扩大和改善其研究核心设施。特鲁多研究所是一家小型非营利性研究机构，致力于识别调节年轻人和老年人对传染病、自身免疫和癌症的免疫力的机制。特鲁多研究人员的研究目标直接涉及改善人类健康和提高我们应对新出现的传染病和生物恐怖威胁的能力的国家目标。特鲁多研究所是生物防御研究区域卓越中心的一部分，拥有大量 PHS 拨款，直接成本总计近 7,000,000 美元。特鲁多研究所的研究依赖于最先进的核心设施，包括动物、分子生物学、流式细胞术和动物技术服务核心。然而，这些核心必须得到扩展和改进，以满足研究者当前和未来的研究需求。例如，ABSL-2 和 ABSL-3 设施已有 40 年历史，需要进行重大更新和扩建。此外，分子生物学、流式细胞术和动物技术服务核心需要巩固和扩展。因此，我们建议建造一座新建筑来容纳需要 ABSL-2（目标 1）、ABSL-3（目标 2）或检疫级遏制（目标 3）的小鼠。新大楼还将提供进行传染病研究（目标 4）所需的动物设施基础设施和设备。最后，我们建议翻新目前用于饲养受感染动物的空间，以便为分子生物学、流式细胞术和动物技术服务核心提供扩大、巩固和连续的空间（目标 5）。