Enhance Facilities for Infectious Disease Imaging

加强传染病成像设施

• 批准号: 7898280
• 负责人: Clifford RICK LYONS
• 金额: $ 606.39万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-25 至 2015-03-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7898280
• 关键词: Address; Animal Experiments; Animals; Arts; Biological; Biomedical Research; Biotechnology; Cavia; Colorado; Communicable Diseases; Communities; Complex; Development; Devices; Diagnostic; Disease; Economic Models; Emerging Communicable Diseases; Environment; Environmental Wind; Equipment; Facility Accesses; Funding; Generations; Genomics; Gold; Image; Infectious Diseases Research; Interruption; Laboratories; Mus; Nature; Occupations; PET/CT scan; Phase; Positioning Attribute; Power Sources; Proteomics; Radioactive; Request for Proposals; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resolution; Resources; Rest; Safety; Secure; Security; Source; Staging; Technology; Therapeutic Agents; Time; Universities; Work; animal facility; college; design; economic impact; feeding; global environment; improved; in vivo; innovation; interest; member; novel therapeutics; pathogen; prevent; programs; research facility; research study; tool

DESCRIPTION (provided by applicant): This proposal requests funds to complete construction of an Imaging Facility devoted to work with BSL- 3 pathogens and Select Agents and to provide an underground electrical feed to the Imaging Facility and the rest of the Infectious Disease Research Center. The Imaging Facility will be located within the Judson M. Harper Research Complex on the Foothills Campus of Colorado State University. It will be part of the Infectious Disease Research Center (IDRC), adjacent to the Rocky Mountain Regional Biocontainment Laboratory (RMRBL). The Imaging Facility was originally part of a Research Innovation Center construction project, but budgetary constraints at the Design Development phase of construction caused the University to core-and-shell the Imaging Facility. This request will allow the completion of this Imaging Facility and provide an essential main electrical feed to supply secure, steady and reliable power for state-of-the-art imaging equipment, high-technology sequencing and analytical laboratory machines, HVAC, and safety/security needs at the Center. Completion of this project will provide the following benefits to the University and the biomedical research community. 1). New space will be created for BSL-2 and BSL-3 infectious disease research. 2). The Imaging Facility will enable the generation of diagnostic information on translational stage studies of new therapeutics and devices taking place in the Infectious Disease Research Center by providing real-time in vivo images. 3). The Imaging Facility build-out will provide space for animal facilities and allow imaging within a BSL-3 contained environment. 4). The Imaging Facility will be constructed within a secure, controlled-access facility, assuring the safe conduct of animal experiments under BSL-3 conditions. 5). Construction of the Imaging Facility (Specific Aim 1 of this proposal) will improve the conduct of PHS-funded research projects, and greatly expand the scope and nature of biomedical experiments conducted on campus. Researchers currently using the RMRBL are members of the Rocky Mountain Regional Center of Excellence in Biodefence and Emerging Infectious Disease Research (RMRCE), and the Imaging Facility will enhance their research programs dramatically. The Proteomics/Genomics Laboratory, a core laboratory of the RMRCE, has been impacted by frequent power fluctuations and interruptions, a deficiency that will be addressed by Specific Aim 2 of this proposal. 6). Completion of the Imaging Facility will enhance the networked environment available for biomedical research, such as capture of high-resolution images of infected and uninfected animals, both as they develop disease and as therapeutic agents interfere with or prevent the progression of infectious diseases. CSU's commitment to sustainable building is evidenced by seven concurrent LEED gold buildings under construction, one of which is the Research Innovation Center on the Foothills Campus. The University has also recently launched a College for Global Environmental Sustainability, and the University administration has issued directives towards achieving energy neutral buildings by offsetting conventional supplies with solar and wind sources. The current project will be LEED certified. An economic model determined that this project will directly support 59 full-time jobs with an additional 37.4 spin-off positions, generating $4,630,895 in total payroll in the first year, and $406,298 in total ongoing economic impact from job creation. This proposal requests funds ($6,230,546) for an integrated project of completing a core-and-shell research facility plus providing vital electric infrastructure. Equipment requested include Techiplast animal caging and transfer racks for mice, Thoren caging and transfer racks for guinea pigs, biological safety cabinets designed and equipped for animal cage changing and animal manipulation, and shielding equipment required for work with radioactive materials associated with PET/CT imaging. Rationale: The Infectious Disease Imaging Facility will provide a unique capability that will be an important resource unavailable elsewhere in the Rocky Mountain region, and add to the limited national capabilities currently available. This Facility will vastly improve the research tools available to a very strong infectious disease research community in Fort Collins, and will be of major interest to biotechnology/discovery companies, federal bioscience departments and laboratories, both regionally and nationally. Completion of the underground power feed will address a long-standing concern about the lack of a secure, redundant power feed to the Regional Biocontainment Laboratory, greatly enhance the security of the complex, and provide a steady, reliable, and uninterrupted power source.

描述（由申请人提供）：该提案要求提供资金来完成专门用于处理 BSL-3 病原体和精选病原体的成像设施的建设，并为成像设施和传染病研究中心的其他部分提供地下供电。该成像设施将位于科罗拉多州立大学山麓校区的 Judson M. Harper 研究中心内。它将成为传染病研究中心 (IDRC) 的一部分，毗邻落基山地区生物防护实验室 (RMRBL)。该成像设施最初是研究创新中心建设项目的一部分，但建设设计开发阶段的预算限制导致大学对成像设施进行了核心和外壳改造。该请求将允许完成该成像设施，并提供必要的主电源，为最先进的成像设备、高科技测序和分析实验室机器、HVAC 和安全/提供安全、稳定和可靠的电力。中心的安全需求。该项目的完成将为大学和生物医学研究界带来以下好处。 1）。将为 BSL-2 和 BSL-3 传染病研究创造新的空间。 2）。该成像设施将通过提供实时体内图像，生成传染病研究中心进行的新疗法和设备转化阶段研究的诊断信息。 3）。成像设施扩建将为动物设施提供空间，并允许在 BSL-3 封闭环境中进行成像。 4）。该成像设施将建在安全、受控访问的设施内，确保在 BSL-3 条件下安全进行动物实验。 5）。成像设施的建设（本提案的具体目标1）将改善PHS资助的研究项目的开展，并大大扩大校园内进行的生物医学实验的范围和性质。目前使用 RMRBL 的研究人员是落基山生物防御和新发传染病研究卓越区域中心 (RMRCE) 的成员，成像设施将极大地增强他们的研究项目。 RMRCE的核心实验室蛋白质组/基因组实验室受到频繁的电源波动和中断的影响，这一缺陷将通过本提案的具体目标2来解决。 6).成像设施的建成将增强可用于生物医学研究的网络环境，例如捕获受感染和未受感染动物的高分辨率图像，无论是在它们发病时还是作为治疗剂干扰或预防传染病的进展时。 科罗拉多州立大学对可持续建筑的承诺体现在七座正在建设的 LEED 金牌建筑中，其中之一是位于山麓校区的研究创新中心。该大学最近还成立了全球环境可持续发展学院，大学管理部门已发布指令，通过太阳能和风能抵消传统供应来实现能源中性建筑。当前项目将获得 LEED 认证。经济模型确定该项目将直接支持 59 个全职工作岗位以及额外的 37.4 个衍生职位，第一年产生的工资总额为 4,630,895 美元，创造就业机会带来的持续经济影响总额为 406,298 美元。该提案要求为完成核壳研究设施以及提供重要电力基础设施的综合项目提供资金（6,230,546 美元）。 所需设备包括用于小鼠的 Techiplast 动物笼养和转移架、用于豚鼠的 Thoren 笼养和转移架、为动物笼更换和动物操作而设计和装备的生物安全柜，以及与 PET/CT 成像相关的放射性材料工作所需的屏蔽设备。 理由：传染病成像设施将提供一种独特的能力，这将成为落基山脉地区其他地方无法获得的重要资源，并补充目前有限的国家能力。该设施将极大地改善柯林斯堡强大的传染病研究界可用的研究工具，并将引起地区和国家生物技术/发现公司、联邦生物科学部门和实验室的重大兴趣。地下供电系统的建成，将解决区域生物防护实验室长期以来缺乏安全、冗余供电的问题，大大提高综合体的安全性，并提供稳定、可靠、不间断的电源。