EXERCISE TO IMPROVE HRV IN SUDDEN CARDIAC ARREST

通过锻炼改善心脏骤停时的 HRV

• 批准号: 6612909
• 负责人: CYNTHIA M DOUGHERTY
• 金额: $ 8.64万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6612909
• 关键词: arrhythmia; cardiovascular disorder prevention; cardiovascular disorder therapy; clinical research; cytoprotection; exercise; heart arrest; heart function; human subject; human therapy evaluation; implantable defibrillators; medical rehabilitation related tag; parasympathetic nervous system; patient oriented research; relapse /recurrence

DESCRIPTION (provided by applicant): The candidate?s long-term goal is to develop exercise prescriptions that improve physical and psychosocial health of survivors of sudden cardiac arrest (SCA). To achieve this goal a focused research career development Plan is proposed, including intensive study of: 1) cardiopulmonary exercise and metabolic testing, 2) measurement of cardiac autonomic nervous system function (heart rate variability), and 3) advanced statistical analysis of heart rate data. The purpose of this proposal is to determine the safety and feasibility of an exercise intervention in survivors (N= 10) of SCA who have automatic internal cardioverter defibrillators (ICDs). Secondarily, testing the impact of exercise on cardiac autonomic function (heart rate variability (HRV), health outcomes (heart rhythm stability, general health related quality of life, psychological distress), and major adverse cardiac events (cardiac hospitalizations, ER visits, and cardiac mortality) is proposed. The primary outcomes are safety and feasibility in implementing the exercise intervention from baseline to 8 weeks. SCA claims approximately 300,000 lives in the US per year, representing 40 percent of the total deaths resulting from cardiovascular disease. SCA often occurs outside the hospital without warning, where most resuscitated victims receive an ICD at the time of hospitalization. Approximately 29 percent of persons survive the initial cardiac arrest, with greater than 40,000 persons/year undergoing ICD implantation. The development of malignant ventricular arrhythmias at the time of SCA has been attributed in part to imbalances in autonomic nervous system function. Increased sympathetic nervous system activity and decreased parasympathetic activity has been shown to result in more ventricular arrhythmias. Protection against SCA may be achieved through mechanisms that increase parasympathetic tone, exercise being one of these therapies. Exercise training is an inexpensive, nonpharmacological intervention that is essentially devoid of negative side effects and virtually available to everyone. My interest is in determining if exercise will affect cardiac parasympathetic nervous system regulation and therefore convey cardioprotective effects that will subsequently influence rates of recurrence of ventricular arrhythmias, ICD shocks, and cardiac mortality. The results of this study have the potential to impact future exercise recommendations and prescriptions, feasibility, safety, and quality of life in SCA survivors with ICD?s.

描述（由申请人提供）： 候选人的长期目标是 制定可改善身体和心理健康的运动处方 心脏骤停（SCA）的幸存者。为了实现这一目标，重点 提出研究职业发展计划，包括深入研究：1） 心肺运动和代谢测试，2）心脏测量 自主神经系统功能（心率变异性），以及 3) 高级 心率数据的统计分析。该提案的目的是 确定幸存者运动干预的安全性和可行性 (N= 10) 的 SCA 拥有自动体内心脏复律除颤器 (ICD)。 其次，测试运动对心脏自主功能的影响 （心率变异性 (HRV)、健康结果（心律稳定性、一般情况 健康相关的生活质量、心理困扰）以及主要不良反应 心脏事件（心脏住院、急诊室就诊和心脏死亡） 建议的。主要成果是实施该计划的安全性和可行性 从基线到 8 周的运动干预。 SCA 索赔大约 美国每年有 30 万人丧生，占总死亡人数的 40% 由心血管疾病引起。 SCA 经常发生在医院外 在没有任何警告的情况下，大多数复苏的受害者在接受 ICD 时 住院治疗。大约 29% 的人在最初的过程中幸存下来 心脏骤停，每年有超过 40,000 人接受 ICD 植入。当时恶性室性心律失常的发展 SCA 的部分原因是自主神经系统失衡 功能。交感神经系统活动增加，交感神经系统活动减少 副交感神经活动已被证明会导致更多的心室 心律失常。针对 SCA 的保护可以通过以下机制来实现： 增加副交感神经张力，运动是这些疗法之一。锻炼 培训是一种廉价的非药物干预措施，本质上是 没有负面副作用，几乎每个人都可以使用。我的 兴趣在于确定运动是否会影响心脏副交感神经 神经系统调节，从而传达心脏保护作用 随后将影响室性心律失常（ICD）的复发率 休克和心脏死亡率。这项研究的结果有可能 影响未来的运动建议和处方、可行性、安全性、 以及使用 ICD 的 SCA 幸存者的生活质量。