EXERCISE TO IMPROVE HRV IN SUDDEN CARDIAC ARREST

通过锻炼改善心脏骤停时的 HRV

• 批准号: 7379341
• 负责人: CYNTHIA M DOUGHERTY
• 金额: $ 0.17万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7379341
• 关键词: EXERCISE; IMPROVE; HRV; SUDDEN; CARDIAC

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this proposal is to determine the safety and feasibility of an exercise intervention in survivors (N=10) of sudden cardiac arrest (SCA) who have automatic implantable cardioverter defibrillators (ICDs). Secondarily, testing the impact of exercise on cardiac autonomic function (heart rate variability (HRV), health outcomes (heart rhythm stability, general health related quality of life, psychological distress), and major adverse cardiac events (cardiac hospitalizations, ER visits, and cardiac mortality) is proposed. The primary outcomes are safety and feasibility in implementing the exercise intervention from baseline to 8 weeks. Our interest is in determining if exercise will affect cardiac parasympathetic nervous system regulation and convey cardioprotective effects on recurrence of ventricular arrhythmias, ICD shocks, and cardiac mortality.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。该提案的目的是确定对拥有自动植入式心脏复律除颤器 (ICD) 的心脏骤停 (SCA) 幸存者 (N=10) 进行运动干预的安全性和可行性。其次，测试运动对心脏自主功能（心率变异性 (HRV)、健康结果（心律稳定性、一般健康相关的生活质量、心理困扰）以及主要心脏不良事件（心脏住院、急诊就诊和住院治疗）的影响。提出的主要结果是从基线到 8 周实施运动干预的安全性和可行性。我们的兴趣是确定运动是否会影响心脏副交感神经系统调节并对心室复发产生心脏保护作用。心律失常、ICD 电击和心脏死亡。