Genetics, Exposures, and RA-Related Autoimmunity

遗传学、暴露和 RA 相关自身免疫

• 批准号: 6938495
• 负责人: Kevin Deane
• 金额: $ 13.13万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6938495
• 关键词: autoantibody; clinical research; disease /disorder etiology; family genetics; gene environment interaction; genetic susceptibility; histocompatibility gene; human genetic material tag; human subject; immunogenetics; immunopathology; molecular pathology; patient oriented research; protein structure function; rheumatoid arthritis

DESCRIPTION (provided by applicant): Candidate's Career Goals: At the end of this award, the candidate plans to have developed the skills necessary to be an independent clinical investigator in the field of immunopathogenesis and autoimmunity. His long-term career goal is use the training acquired during this award period to remain in an academic setting, participating as an independent researcher in the creation of a new paradigm in autoimmune disease where susceptibility to disease is determined in the pre-clinical state, and early measures can be halt the onset or early progression of disease. Research Career Development Plan: During the period of this award, there will be two major components to the candidate's research training. The first will be the candidate's participation in formal education in clinical research through the Ph.D. Program in Clinical Science offered at the University of Colorado Health Sciences Center. The second will be the candidate's involvement in the NIH-funded project Studies of the Etiologies of Rheumatoid Arthritis (SERA), under the guidance of mentors V. Michael Holers and Jill Norris. Description of Research Project: During the period of this award, the candidate's involvement in research will focus on an arm of the SERA project evaluating the relationship between HLA alleles, environmental exposures, and the development of RA- related autoimmunity in a cohort of approximately 2700 healthy first-degree relatives of patients with RA. The long-term goals of both the candidate and the larger SERA project are to identify potential etiologic mechanisms for RA, as well as to develop a model for predicting the development of disease in healthy subjects, ultimately selecting subjects who would be candidates for preventive or very early therapeutic interventions.

描述（由申请人提供）：候选人的职业目标：在本奖项结束时，候选人计划开发成为免疫发育生成和自身免疫领域的独立临床研究者所必需的技能。他的长期职业目标是利用在此奖项期间获得的培训来保持学术环境，作为独立研究人员的参与，创建了一种新的自身免疫性疾病范式，在临床前状态下确定对疾病的易感性，并且可以停止早期措施或早期疾病的发作或早期进展。 研究职业发展计划：在本奖项期间，候选人的研究培训将有两个主要组成部分。第一个将是候选人通过博士学位参加临床研究的正规教育。科罗拉多大学健康科学中心提供的临床科学计划。第二个将是候选人参与NIH资助的类风湿关节炎病因（Sera）的项目研究，在导师V. Michael Holers和Jill Norris的指导下。 研究项目的描述：在本奖项期间，候选人参与研究的参与将集中在血清项目的一个部门上，评估HLA等位基因，环境暴露与RA与RA相关自身免疫的发展之间的关系，在大约2700个健康的RA患者的健康一级亲戚中。候选人和较大的血清项目的长期目标是确定RA的潜在病因机制，并开发一个模型来预测健康受试者中疾病的发展，最终选择将成为预防或非常早期治疗干预措施的受试者。