Genetics, Exposures, and RA-Related Autoimmunity

遗传学、暴露和 RA 相关自身免疫

• 批准号: 7480332
• 负责人: Kevin Deane
• 金额: $ 13.13万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7480332
• 关键词: Address; Affect; Alleles; Appearance; Autoantibodies; Autoimmune Diseases; Autoimmune Process; Autoimmunity; Award; Caffeine; Child; Clinical; Clinical Investigator; Clinical Research; Clinical Sciences; Coffee; Colorado; Condition; Consumption; Data; Development; Development Plans; Diabetes Mellitus; Disease; Disease Progression; Disease susceptibility; Doctor of Philosophy; Early treatment; Education; Environmental Exposure; Environmental Risk Factor; Epidemiologic Studies; Estrogens; Etiology; Evolution; Exhibits; Exposure to; First Degree Relative; Funding; Genetic; Genetic Risk; Goals; Health Sciences; Hyperglycemia; Individual; Infection; Inflammatory; Injury; Insulin-Dependent Diabetes Mellitus; Joints; Measures; Mentors; Modeling; Morbidity - disease rate; Organ; Pathogenesis; Patients; Pattern; Phase; Play; Population; Populations at Risk; Prevention; Prevention strategy; Preventive; Preventive Intervention; Process; Randomized; Recruitment Activity; Research; Research Personnel; Research Project Grants; Research Training; Rheumatoid Arthritis; Risk; Role; Silicon Dioxide; Site; Smoking; Therapeutic Intervention; Toxic Environmental Substances; Training; Universities; Upper arm; Work; base; career; cohort; insight; interest; mortality; pre-clinical; programs; skills

DESCRIPTION (provided by applicant): Candidate's Career Goals: At the end of this award, the candidate plans to have developed the skills necessary to be an independent clinical investigator in the field of immunopathogenesis and autoimmunity. His long-term career goal is use the training acquired during this award period to remain in an academic setting, participating as an independent researcher in the creation of a new paradigm in autoimmune disease where susceptibility to disease is determined in the pre-clinical state, and early measures can be halt the onset or early progression of disease. Research Career Development Plan: During the period of this award, there will be two major components to the candidate's research training. The first will be the candidate's participation in formal education in clinical research through the Ph.D. Program in Clinical Science offered at the University of Colorado Health Sciences Center. The second will be the candidate's involvement in the NIH-funded project Studies of the Etiologies of Rheumatoid Arthritis (SERA), under the guidance of mentors V. Michael Holers and Jill Norris. Description of Research Project: During the period of this award, the candidate's involvement in research will focus on an arm of the SERA project evaluating the relationship between HLA alleles, environmental exposures, and the development of RA- related autoimmunity in a cohort of approximately 2700 healthy first-degree relatives of patients with RA. The long-term goals of both the candidate and the larger SERA project are to identify potential etiologic mechanisms for RA, as well as to develop a model for predicting the development of disease in healthy subjects, ultimately selecting subjects who would be candidates for preventive or very early therapeutic interventions.

描述（由申请人提供）： 候选人的职业目标： 在该奖项结束时，候选人计划发展成为免疫发病机制和自身免疫领域的独立临床研究者所需的技能。他的长期职业目标是利用在此获奖期间获得的培训留在学术环境中，作为独立研究人员参与创建自身免疫性疾病的新范例，其中疾病的易感性是在临床前状态确定的，早期措施可以阻止疾病的发作或早期进展。 研究职业发展计划：在该奖项期间，候选人的研究培训将有两个主要组成部分。首先是候选人通过博士学位参与临床研究的正规教育。科罗拉多大学健康科学中心提供临床科学课程。第二个项目是候选人在导师 V. Michael Holers 和 Jill Norris 的指导下参与 NIH 资助的项目“类风湿关节炎病因研究”(SERA)。 研究项目描述：在该奖项期间，候选人参与的研究将集中于 SERA 项目的一个分支，该项目在大约 2700 名受试者中评估 HLA 等位基因、环境暴露和 RA 相关自身免疫发展之间的关系RA患者的健康一级亲属。候选者和更大的 SERA 项目的长期目标是确定 RA 的潜在病因机制，以及开发一个模型来预测健康受试者疾病的发展，最终选择将成为预防或治疗候选者的受试者。非常早期的治疗干预。

项目成果

Rheumatoid arthritis (RA)-specific autoantibodies in patients with interstitial lung disease and absence of clinically apparent articular RA.

• DOI: 10.1007/s10067-009-1128-9
• 发表时间: 2009-05
• 期刊: CLINICAL RHEUMATOLOGY
• 影响因子: 3.4
• 作者: Gizinski, Alison M.;Mascolo, Margherita;Loucks, Jennifer L.;Kervitsky, Alma;Meehan, Richard T.;Brown, Kevin K.;Holers, V. Michael;Deane, Kevin D.
• 通讯作者: Deane, Kevin D.