Core 1

核心1

• 批准号: 10700079
• 负责人: Kevin Deane
• 金额: $ 22.62万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-10 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10700079
• 关键词: Address; Area; Autoimmune Diseases; Awareness; Biological Markers; Biology; Blood; Budgets; Chronic; Clinical; Clinical Research; Collection; Colorado; Data; Data Science; Development; Diagnosis; Dietary intake; Disease; Environmental Exposure; Evaluation; Future; Human Subject Research; Immunobiology; Individual; Inflammation; Inflammatory Bowel Diseases; Institutional Review Boards; Insulin-Dependent Diabetes Mellitus; Joints; Leadership; Medical History; Mind; Mucosal Immune System; Mucous Membrane; Natural History; Organ; Outcome; Outcome Assessment; Pain; Pathogenesis; Performance; Personal Satisfaction; Phase; Population Sciences; Prevention; Prevention strategy; Process; Reporting; Research; Research Design; Research Personnel; Resources; Rheumatism; Rheumatoid Arthritis; Role; Sampling; Self Tolerance; Series; Site; Spondylarthritis; Symptoms; Tobacco use; Training; Universities; Work; biobank; career; catalyst; cohort; data management; data repository; data sharing networks; didactic education; disease natural history; dysbiosis; innovation; lectures; member; mucosal site; outreach; predictive marker; programs; recruit; skills; social media; website development

An emerging understanding of the natural history of rheumatic disease where a ‘pre-disease’ state can be identified has led to completed prevention studies in several rheumatic and autoimmune diseases (e.g. type 1 diabetes, rheumatoid arthritis), with many other trials underway. The emergence of potential prevention strategies in rheumatic and autoimmune diseases highlights the importance of fully understanding the mechanisms underlying the development of these diseases, from their initiation with being positive for a predictive biomarker yet without target organ involvement through to the phase(s) of clinically-apparent disease and extensive organ damage. Importantly, as a result of research advances over the past several years, including a number made by members of this University of Colorado (CU) Rheumatic Disease Research Resource Center (RDRRC) proposal, a hypothesis now exists for a key role of chronic inflammation and dysbiosis within the mucosal immune system as a catalyst for both the initial break in self-tolerance in asymptomatic individuals as well as a continued driver to clinical disease development and increasing target organ damage. Exploration of this hypothesis across rheumatic and autoimmune diseases through multiple evolving stages of disease, and the integration of multiple sites within the body (e.g. blood, mucosal sites, and joints), requires special skill sets in study design, assessments such as subject-reported outcomes (e.g. pain, well-being) and environmental exposures (e.g. dietary intake, tobacco use), biospecimen collection and processing (including blood and mucosal samples), and analyses. To address these important issues, the role of the RDRRC Resource Core 1: Population and Data Sciences is to provide advisory support for high-quality studies in rheumatic disease as well as unique access to banked data and biospecimens as well as ‘living biorepositories’ of informative subjects. These activities will facilitate research into the natural history of rheumatic disease around the role of mucosal processes. Importantly, the Core’s activities are also expected to recruit new investigators into this area by providing the support and materials necessary to facilitate their awareness and research opportunities. In aggregate, these activities as well as the other RDRRC activities should advance the field in terms of understanding disease pathogenesis, diagnosis and treatment, as well as actionable prevention of rheumatic disease.

对风湿病的自然史的新兴了解可以是“前疾病”状态 确定的已导致了几种风湿性和自身免疫性疾病的完整预防研究（例如1型 糖尿病，类风湿关节炎），正在进行许多其他试验。潜在预防的出现 风湿病和自身免疫性疾病的策略强调了完全理解的重要性 这些疾病开发的基础机制是从它们的启动开始，对 预测性生物标志物却没有目标器官参与到临床疾病的阶段 和广泛的器官损坏。重要的是，由于过去几年的研究进展， 包括科罗拉多大学（CU）风湿病研究成员的数字 资源中心（RDRRC）提案，现在存在一个假设，是慢性炎症和 粘膜免疫系统中的营养不良，作为催化剂的催化剂 无症状的个体以及持续的临床疾病发展和靶向驱动力 器官损坏。通过多种风湿性和自身免疫性疾病探索这种假设 疾病的发展阶段，以及体内多个部位的整合（例如，血液，粘膜部位和 关节），需要研究设计中的特殊技能，评估诸如主题报告的结果（例如疼痛， 幸福感）和环境暴露（例如饮食摄入量，烟草使用），生物环节收集和 加工（包括血液和粘膜样品）和分析。为了解决这些重要问题，角色 RDRRC资源核心1：人口和数据科学是为高质量提供咨询支持 风湿性疾病的研究以及独特的对银行数据和生物测量的访问以及“生活” 生物关注者的内容丰富的主题。这些活动将促进研究的自然历史 围绕粘膜过程的作用的风湿病。重要的是，核心的活动也有望 通过提供促进他们的支持和材料来招募新的研究人员 意识和研究机会。总体而言，这些活动以及其他RDRRC活动 应该在理解疾病发病机理，诊断和治疗以及 可防止风湿病的预防。