Core 1

核心1

• 批准号: 10700079
• 负责人: Kevin Deane
• 金额: $ 22.62万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-10 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10700079
• 关键词: Address; Area; Autoimmune Diseases; Awareness; Biological Markers; Biology; Blood; Budgets; Chronic; Clinical; Clinical Research; Collection; Colorado; Data; Data Science; Development; Diagnosis; Dietary intake; Disease; Environmental Exposure; Evaluation; Future; Human Subject Research; Immunobiology; Individual; Inflammation; Inflammatory Bowel Diseases; Institutional Review Boards; Insulin-Dependent Diabetes Mellitus; Joints; Leadership; Medical History; Mind; Mucosal Immune System; Mucous Membrane; Natural History; Organ; Outcome; Outcome Assessment; Pain; Pathogenesis; Performance; Personal Satisfaction; Phase; Population Sciences; Prevention; Prevention strategy; Process; Reporting; Research; Research Design; Research Personnel; Resources; Rheumatism; Rheumatoid Arthritis; Role; Sampling; Self Tolerance; Series; Site; Spondylarthritis; Symptoms; Tobacco use; Training; Universities; Work; biobank; career; catalyst; cohort; data management; data repository; data sharing networks; didactic education; disease natural history; dysbiosis; innovation; lectures; member; mucosal site; outreach; predictive marker; programs; recruit; skills; social media; website development

An emerging understanding of the natural history of rheumatic disease where a ‘pre-disease’ state can be identified has led to completed prevention studies in several rheumatic and autoimmune diseases (e.g. type 1 diabetes, rheumatoid arthritis), with many other trials underway. The emergence of potential prevention strategies in rheumatic and autoimmune diseases highlights the importance of fully understanding the mechanisms underlying the development of these diseases, from their initiation with being positive for a predictive biomarker yet without target organ involvement through to the phase(s) of clinically-apparent disease and extensive organ damage. Importantly, as a result of research advances over the past several years, including a number made by members of this University of Colorado (CU) Rheumatic Disease Research Resource Center (RDRRC) proposal, a hypothesis now exists for a key role of chronic inflammation and dysbiosis within the mucosal immune system as a catalyst for both the initial break in self-tolerance in asymptomatic individuals as well as a continued driver to clinical disease development and increasing target organ damage. Exploration of this hypothesis across rheumatic and autoimmune diseases through multiple evolving stages of disease, and the integration of multiple sites within the body (e.g. blood, mucosal sites, and joints), requires special skill sets in study design, assessments such as subject-reported outcomes (e.g. pain, well-being) and environmental exposures (e.g. dietary intake, tobacco use), biospecimen collection and processing (including blood and mucosal samples), and analyses. To address these important issues, the role of the RDRRC Resource Core 1: Population and Data Sciences is to provide advisory support for high-quality studies in rheumatic disease as well as unique access to banked data and biospecimens as well as ‘living biorepositories’ of informative subjects. These activities will facilitate research into the natural history of rheumatic disease around the role of mucosal processes. Importantly, the Core’s activities are also expected to recruit new investigators into this area by providing the support and materials necessary to facilitate their awareness and research opportunities. In aggregate, these activities as well as the other RDRRC activities should advance the field in terms of understanding disease pathogenesis, diagnosis and treatment, as well as actionable prevention of rheumatic disease.

对风湿病自然史的新认识，其中“病前”状态可以是 已确定的结论已导致完成了几种风湿病和自身免疫性疾病（例如 1 型 糖尿病、类风湿性关节炎），还有许多其他试验正在进行中，潜在预防的出现。 风湿病和自身免疫性疾病的策略强调了充分理解的重要性 这些疾病发展的潜在机制，从疾病发生到对疾病产生积极影响 预测性生物标志物，但没有靶器官参与直至临床明显疾病的阶段 重要的是，由于过去几年的研究进展， 包括科罗拉多大学 (CU) 风湿病研究中心成员制作的数据 资源中心（RDRRC）提案，现在存在一个关于慢性炎症和炎症的关键作用的假设 粘膜免疫系统内的生态失调是自我耐受性最初突破的催化剂 无症状个体以及临床疾病发展和增加目标的持续驱动力 通过多种方式探索风湿病和自身免疫性疾病的这一假设。 疾病的演变阶段以及体内多个部位的整合（例如血液、粘膜部位和 关节），需要研究设计、评估等方面的特殊技能（例如受试者报告的结果（例如疼痛、 健康）和环境暴露（例如饮食摄入、烟草使用）、生物样本采集和 处理（包括血液和粘膜样本）和分析对于解决这些重要问题的作用。 RDRRC 资源核心 1：人口和数据科学的目的是为高质量的研究提供咨询支持 风湿病研究以及对银行数据和生物样本以及“活体”的独特访问 这些活动将促进对自然历史的研究。 重要的是，核心的活动也有望围绕粘膜过程的作用。 通过提供必要的支持和材料来招募新的调查员进入该领域 总的来说，这些活动以及 RDRRC 的其他活动。 应该在了解疾病发病机制、诊断和治疗以及 风湿性疾病的可行预防。