Administrative Core: IDEAL shapes vaccine response, susceptibility to respiratory infectious disease and asthma

管理核心：IDEAL 影响疫苗反应、呼吸道传染病和哮喘的易感性

• 批准号: 10589801
• 负责人: OFER LEVY
• 金额: $ 11.18万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-10 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10589801
• 关键词: Adherence; Asthma; Cells; Childhood; Clinical; Communicable Diseases; Communication; Complement; Data; Development; Dissection; Ensure; Epigenetic Process; Funding; Geography; Goals; Human; Immune; Immune response; Immunology; In Vitro; Infant; Infrastructure; Intellectual Property; International; Leadership; Life; Mediating; Molecular; Outcome; PRTN3 gene; Predisposition; Process; Productivity; Progress Reports; Property Rights; Proteomics; Recommendation; Research Personnel; Research Project Grants; Shapes; Structure; Systems Biology; Technology; Teleconferences; United States National Institutes of Health; Vaccines; Work; conflict resolution; data management; design; improved; in silico; inter-institutional; material transfer agreement; meetings; programs; respiratory; symposium; synergism; timeline; transcriptomics; vaccine response; vaccinology

PROJECT SUMMARY: IDEAL Administrative Core Our overall proposal will investigate immune development in early life (IDEAL) to identify IDEAL endotypes that correspond to key clinical outcomes in childhood, including vaccine response, respiratory infectious disease and asthma. We will accomplish this goal through three distinct yet integrated studies that follow complementary approaches via cutting-edge in silico (project 1, PR1), epigenetic (PR2), and in vitro (PR3) research projects. Given the scientific scope, complexity, and geographic range of the proposed work, the study IDEAL Administrative Core (AC) will be crucial to optimize the quality and impact of the proposed studies and to ensure timely provision of projected deliverables. The goal of the IDEAL-AC is to institute streamlined processes which facilitate productive interactions among investigators from each IDEAL Project and Core. We will achieve this goal by pursuing the following Specific Aims (SAs): SA1. Provide infrastructure for administrative leadership aimed at building an interactive and collaborative working team resulting in maximal project synergy. SA2. Facilitate and promote communication and interactions amongst the Project and Core Leads by conducting regular teleconferences/face-to-face meetings, annual meetings, as well as seminars/symposia focused on the IDEAL project. SA3. Manage and optimize communication within our IDEAL team and between our team, the other NIH supported IDEAL teams and the IDEAL Steering Committee. SA4. Resolve potential conflicts that might arise within and outside of our IDEAL project by implementing recommendations of the Conflicts Resolution Group (CRG). SA5. Provide fiscal, regulatory and scientific oversight, review and consolidate yearly progress reports sent to the NIH. SA6. Protect intellectual property rights of our investigators and execute material transfer agreements. SA7. Implement the data management/sharing plan among investigators within and outside of our IDEAL team. Overall, the IDEAL AC will ensure appropriate stewardship of NIH funds and maintain adherence to project timelines, all with the goal to optimize and amplify the scientific impact of the proposed studies.

项目摘要：理想的管理核心 我们的总体建议将调查生命早期的免疫发育 (IDEAL)，以确定 IDEAL 内型 与儿童时期的关键临床结果相对应，包括疫苗反应、呼吸道传染病 疾病和哮喘。我们将通过以下三项不同但综合的研究来实现这一目标 通过尖端计算机（项目 1，PR1）、表观遗传学（PR2）和体外（PR3）的补充方法 研究项目。鉴于拟议工作的科学范围、复杂性和地理范围， 研究 IDEAL 管理核心 (AC) 对于优化拟议项目的质量和影响至关重要 研究并确保及时提供预计的可交付成果。 IDEAL-AC 的目标是建立 简化的流程，促进每个 IDEAL 项目的研究人员之间富有成效的互动 和核心。我们将通过追求以下具体目标 (SA) 来实现这一目标： SA1。为行政领导提供基础设施，旨在建立互动和 协作工作团队产生最大的项目协同效应。 SA2。促进和促进项目和核心领导之间的沟通和互动 通过定期举行电话会议/面对面会议、年度会议以及 研讨会/座谈会重点关注 IDEAL 项目。 SA3。管理和优化我们 IDEAL 团队内部以及团队之间的沟通， 其他 NIH 支持 IDEAL 团队和 IDEAL 指导委员会。 SA4。通过以下方式解决 IDEAL 项目内部和外部可能出现的潜在冲突： 实施冲突解决小组 (CRG) 的建议。 SA5。提供财政、监管和科学监督，审查和巩固年度进展 报告发送至 NIH。 SA6。保护我们研究人员的知识产权并执行材料转让 协议。 SA7。在我们内部和外部的研究人员之间实施数据管理/共享计划 理想的团队。 总体而言，IDEAL AC 将确保 NIH 资金的适当管理并保持遵守 项目时间表，所有这些都是为了优化和扩大拟议研究的科学影响。