Ventricular Size and Value Calcification Measures by CT

通过 CT 测量心室大小和钙化值

• 批准号: 6558118
• 负责人: MATTHEW J BUDOFF
• 金额: $ 23.47万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6558118
• 关键词: atherosclerosis; bioimaging /biomedical imaging; calcification; cardiovascular disorder epidemiology; cardiovascular disorder risk; clinical research; computed axial tomography; heart dimension /size; heart imaging /visualization /scanning; human data; human middle age (35-64); human old age (65+); noninvasive diagnosis

DESCRIPTION (provided by applicant): This study is ancillary study proposal for the MultiEthnic Study of Atherosclerosis (MESA) Trial, a prospective investigation of the etiology and natural history of atherosclerosis and the ability of non-invasive tools to measure atherosclerotic burden and identify high, risk individuals in a large, population-based cohort. The development of computed tomography (CT) to evaluate coronary calcification (CC) now provides a tool to directly measure coronary atherosclerosis non-invasively. The information obtained by CT however provides more information than CC alone. CT has the ability to measure and quantitate aortic valve calcification (AVC), mitral annular calcification (MAC), aortic wall calcification and left ventricular size (LVS). The longitudinal nature of this study will allow epidemiologic associations to be established for a multitude of risk factors and these measures, establishing both the time sequence for each measure and consistency of the association in a variety of populations (ethnicity, gender, geographical location and age). Magnetic resonance imaging of the heart will also be obtained as part of the MESA trial, and comparisons of LV size by CT to magnetic resonance measures will also be performed. We propose to utilize scans already obtained as part of the calcium scanning (at baseline and 3.5 year follow-up), and make these four measures on baseline and follow-up scans obtained. The additive value of these simple measures to CC score could possibly provide clinicians with even more power to identify and stratify the high-risk cardiac patient with both findings. This study will also establish the prevalence, in a population based study, of all both AVC and MAC, using a technique highly sensitive to see these abnormalities. It has been postulated that a 'total atherosclerotic burden' could be obtained by adding CAC to thoracic aortic calcification, and this total atherosclerosis score (with or without MAC and AVC) might better predict cardiovascular events than CAC alone. Similarly, this cohort of 6500 patients with repeat scans can be assessed for factors that enhance or inhibit progression of LVS, mitral annular, aortic valve or wall calcification, lending insight into therapies that have efficacy against progression of aortic sclerosis or left ventricular enlargement.

描述（由申请人提供）：本研究是动脉粥样硬化多种族研究 (MESA) 试验的辅助研究提案，该试验是对动脉粥样硬化病因和自然史的前瞻性调查，以及非侵入性工具测量动脉粥样硬化负荷和识别高动脉粥样硬化负担的能力。 ，在一个基于人群的大型队列中对个体进行风险评估。用于评估冠状动脉钙化（CC）的计算机断层扫描（CT）的发展现在提供了一种直接非侵入性测量冠状动脉粥样硬化的工具。然而，通过 CT 获得的信息比单独的 CC 提供的信息更多。 CT 能够测量和定量主动脉瓣钙化 (AVC)、二尖瓣环钙化 (MAC)、主动脉壁钙化和左心室大小 (LVS)。这项研究的纵向性质将允许为多种危险因素和这些措施建立流行病学关联，确定每个措施的时间顺序以及各种人群（种族、性别、地理位置和年龄）中关联的一致性。 ）。作为 MESA 试验的一部分，还将获得心脏的磁共振成像，并将 CT 测量的左心室大小与磁共振测量结果进行比较。我们建议利用已获得的扫描作为钙扫描的一部分（在基线和 3.5 年随访中），并根据获得的基线和后续扫描进行这四项测量。这些简单的 CC 评分测量方法的附加值可能为临床医生提供更多的能力来识别和分层具有这两种发现的高危心脏病患者。这项研究还将在一项基于人群的研究中确定所有 AVC 和 MAC 的患病率，使用高度敏感的技术来观察这些异常。据推测，通过将 CAC 添加到胸主动脉钙化中可以获得“总动脉粥样硬化负荷”，并且该总动脉粥样硬化评分（有或没有 MAC 和 AVC）可能比单独使用 CAC 更好地预测心血管事件。同样，这组由 6500 名患者组成的重复扫描队列可以评估增强或抑制 LVS、二尖瓣环、主动脉瓣或壁钙化进展的因素，从而深入了解对主动脉硬化或左心室扩大进展有效的治疗方法。