Emotion Regulation and Aggression During Early Abstinence from Methamphetamine

早期戒除甲基苯丙胺期间的情绪调节和攻击性

• 批准号: 7545670
• 负责人: DORIS EVAMARIA PAYER
• 金额: $ 2.94万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7545670
• 关键词: Abstinence; Accounting; Address; Affect; Affective; Aggressive behavior; Amygdaloid structure; Anger; Anxiety; Behavior; Behavioral; Brain; Brain region; Condition; Data; Development; Diffusion Magnetic Resonance Imaging; Disease; Drug abuse; Emotional; Emotional Disturbance; Emotions; Exhibits; Face; Facial Expression; Female; Functional Magnetic Resonance Imaging; Functional disorder; Gender; Goals; Healthcare; Image; Individual; Influentials; Intervention; Label; Lead; Legal; Legal system; Link; Measures; Medical; Mental Depression; Metabolic; Methamphetamine; Methods; Moods; Nature; Neurobiology; Participant; Patient Self-Report; Performance; Personal Satisfaction; Prefrontal Cortex; Problem behavior; Process; Public Health; Quality of life; Questionnaires; Range; Recruitment Activity; Regulation; Relapse; Research; Resources; Role; Safety; Sampling; Sampling Studies; Score; Sex Characteristics; Structure; Substance abuse problem; Symptoms; Taxes; Testing; Time; Violence; base; day; disorder later incidence prevention; disturbance in affect; emotion regulation; improved; male; neural circuit; relating to nervous system; sex; social; success; therapy development; white matter; Abstinence; Accounting; Address; Affect; Affective; Aggressive behavior; Amygdaloid structure; Anger; Anxiety; Behavior; Behavioral; Brain; Brain region; Condition; Data; Development; Diffusion Magnetic Resonance Imaging; Disease; Drug abuse; Emotional; Emotional Disturbance; Emotions; Exhibits; Face; Facial Expression; Female; Functional Magnetic Resonance Imaging; Functional disorder; Gender; Goals; Healthcare; Image; Individual; Influentials; Intervention; Label; Lead; Legal; Legal system; Link; Measures; Medical; Mental Depression; Metabolic; Methamphetamine; Methods; Moods; Nature; Neurobiology; Participant; Patient Self-Report; Performance; Personal Satisfaction; Prefrontal Cortex; Problem behavior; Process; Public Health; Quality of life; Questionnaires; Range; Recruitment Activity; Regulation; Relapse; Research; Resources; Role; Safety; Sampling; Sampling Studies; Score; Sex Characteristics; Structure; Substance abuse problem; Symptoms; Taxes; Testing; Time; Violence; base; day; disorder later incidence prevention; disturbance in affect; emotion regulation; improved; male; neural circuit; relating to nervous system; sex; social; success; therapy development; white matter

DESCRIPTION (provided by applicant): Project Summary: Early abstinence from methamphetamine (MA) is associated with mood and socio-emotional disturbances, including depression and anxiety, but also irritability, problems controlling anger, and a tendency to engage in violent and aggressive behavior. The proposed research will investigate whether deficits in emotion regulation and associated neural circuitry contribute to these behaviors. The studies will test the structural and functional integrity of a neural circuit that includes prefrontal cortex (PFC) and the amygdala in healthy and MA-dependent individuals (abstinent 4-7 days), using functional MRI with a task that involves threatening faces to assess emotion regulation, and diffusion tensor imaging (DTI) to assess white matter integrity. Studies will also assess impulsively aggressive behavior, using self-report scales and a probe task of aggression, and relate measures of aggressiveness to the capacity for emotion regulation and associated brain function/connectivity. Individuals who show difficulty regulating emotion and/or show poor white matter integrity are expected to exhibit higher levels of aggression. Both aims will take into account the potentially influential effects of sex, which can affect brain function/structure and behavior, in particular violent and aggressive impulses. The goal of this research is to form a more thorough understanding of the symptoms associated with early abstinence from MA, as this is a time during which MA-dependent individuals are particularly vulnerable to relapse. Understanding the neural deficits that characterize this period, as well as their relationship to behavioral problems, is crucial for identifying targets for intervention. Identification of specific targets, and the subsequent potential for development of appropriate approaches to address them, could lead to improved treatment retention, relapse prevention, and general well-being of individuals affected by substance abuse disorders. PUBLIC HEALTH RELEVANCE: Methamphetamine (MA) abuse is a major medical, social, and legal concern, and violent and aggressive behaviors associated with MA abuse tax public safety, as well as the health care and legal systems. However, no consistently effective treatment is available, and existing approaches have had limited success. A better understanding of the behavioral and neurobiological deficits associated with early abstinence from MA could prove beneficial for the development of treatments, and help improve quality of life not only for individuals with substance abuse disorders, but also individuals affected by their behavior.

描述（由申请人提供）：项目摘要：甲基苯丙胺（MA）的早期禁欲与情绪和社会情感障碍有关，包括抑郁和焦虑，但也烦躁，控制愤怒的问题以及从事暴力和积极行为的趋势。拟议的研究将调查情绪调节和相关神经回路的缺陷是否有助于这些行为。这些研究将测试神经回路的结构和功能完整性，该神经回路包括前额叶皮层（PFC）和健康和MA依赖性个体中的杏仁核（避免了4-7天），使用功能性MRI，其任务涉及威胁面孔来评估情绪调节的威胁，以评估情绪调节（DTI）来评估白物物质成分。研究还将使用自我报告量表和攻击性的探测任务评估冲动的攻击行为，并将攻击性的衡量标准与情绪调节的能力以及相关的大脑功能/连通性联系起来。表现出难以调节情绪和/或表现出差的白质完整性的个人将表现出更高的侵略水平。这两个目标都将考虑性别的潜在影响力，这可能会影响大脑功能/结构和行为，特别是暴力和侵略性冲动。这项研究的目的是对与MA早期戒酒相关的症状形成更彻底的了解，因为这是MA依赖人特别容易发生复发的时期。了解表征这一时期的神经缺陷以及它们与行为问题的关系，对于识别干预目标至关重要。识别特定目标以及随后开发适当方法来解决这些目标的潜力，可能会改善治疗保留，预防复发和受滥用药物滥用障碍影响的个人的普遍福祉。 公共卫生相关性：甲基苯丙胺（MA）滥用是一种主要的医疗，社会和法律关注，以及与MA滥用税收公共安全以及医疗保健和法律制度相关的暴力和侵略行为。但是，没有一贯的有效治疗方法，现有方法的成功有限。更好地理解与早期禁欲相关的行为和神经生物学缺陷可以证明对治疗的发展有益，并有助于改善生活质量，不仅对患有滥用药物的人的人，而且对受其行为影响的个体也有助于改善生活质量。